PDF herunterladen
Thromb Haemost 1992; 67(05): 514-518
DOI: 10.1055/s-0038-1648484
Original Articles
Schattauer GmbH Stuttgart

A Randomized and Blinded Comparison of Three Bleeding Time Techniques: the Ivy Method, and the Simplate II® Method in Two Directions

R Šrámek
1   The Department of Clinical Epidemiology, University Hospital Leiden, The Netherlands
,
A Šrámek
1   The Department of Clinical Epidemiology, University Hospital Leiden, The Netherlands
,
T Koster
1   The Department of Clinical Epidemiology, University Hospital Leiden, The Netherlands
,
E Briët
2   The Department of Hematology, University Hospital Leiden, The Netherlands
,
F R Rosendaat
1   The Department of Clinical Epidemiology, University Hospital Leiden, The Netherlands
2   The Department of Hematology, University Hospital Leiden, The Netherlands
› Institutsangaben
Weitere Informationen

Publikationsverlauf

Received 07. Mai 1991

Accepted after revision 10. Dezember 1991

Publikationsdatum:
03. Juli 2018 (online)

Auch verfügbar auf
  als PDF herunterladen  Lizenzen und Reprints

Summary

We compared the Ivy bleeding time method and two alternatives of the Simplate II® method (incisions in horizontal and vertical direction) with each other, with regard to the sensitivity, the specificity, the costs and the burden for the patient. In the aspirin study an aspirin-induced bleeding defect was used. Seventy-two healthy volunteers were randomized to receive either 500 mg acetylsalicylic acid (ASA) or a placebo. Double blinding was maintained throughout the study. In the anticoagulation study 62 patients participated, who received oral anticoagulants (OAC) for various reasons. All participants received two bleeding time methods. The burden for the participants of each method was screened by a small standard questionnaire.

The differences in sensitivity and specificity between the three methods proved minimal. The Ivy method was more often preferred by the participants than the Simplate methods.

Since a choice on the basis of sensitivity and specificity appears not possible, we prefer the Ivy method because of lower costs and less burden.

 

  • References

  • 1 Duke WW. The relation of blood platelets to hemorrhagic disease: description of a method for determining the bleeding time and coagulation time and report of three cases of hemorrhagic disease relieved by transfusion. JAMA 1910; 55: 1185-1192
    CrossrefPubMedGoogle Scholar
  • 2 Ivy AC, Shapiro PF, Melnick P. The bleeding tendency in jaundice. Surg Gynecol Obstet 1935; 60: 781-784
    PubMedGoogle Scholar
  • 3 Ivy AC, Nelson D, Bucher G. The standardization of certain factors in the cutaneous “venostasis” bleeding time technique. J Lab Clin Med 1941; 26: 1812-1822
    PubMedGoogle Scholar
  • 4 Mielke Jr CH, Kaneshiro MM, Maher IA, Weiner JM, Rapaport SI. The standardized normal Ivy bleeding time and its prolongation by aspirin. Blood 1969; 34: 204-215
    PubMedGoogle Scholar
  • 5 Koster T, Caekebeke-Peerlinck KMJ, Briet E. A randomized and blinded comparison of the sensitivity and the reproducibility of the Ivy and Simplate II® bleeding time techniques. Am J Clin Pathol 1989; 92: 315-320
    CrossrefPubMedGoogle Scholar
  • 6 Mielke Jr CH. Aspirin prolongation of the template bleeding time: influence of venostasis and direction of incision. Blood 1982; 60: 1139-1142
    CrossrefPubMedGoogle Scholar
  • 7 Buchanan GR, Holtkamp CA. A comparative study of variables affecting the bleeding time using two disposable devices. Am J Clin Pathol 1989; 91: 45-51
    CrossrefPubMedGoogle Scholar
  • 8 Smith PS, Baglini R, Meissner GF. The prolonged bleeding time in hemophilia A: comparison of two measuring technics and clinical associations. Am J Clin Pathol 1985; 83: 211-215
    CrossrefPubMedGoogle Scholar
  • 9 Marongiu F, Biondi G, Sorano GG, Mameli G, Conti M, Mamusa AM, Cadoni MC, Balestrieri A. Bleeding time is prolonged during oral anticoagulant therapy. Thromb Res 1990; 59: 905-912
    CrossrefPubMedGoogle Scholar
  • 10 Pocock SJ. Clinical Trials: a Practical Approach. John Wiley and Sons; Chichester: 1983. pp 84-86
  • 11 De Jonge H. Inleiding tot de medische statistiek. Nederlands Instituut voor Praeventieve Geneeskunde; Leiden: 1958. pp 217-220
    Google Scholar
  • 12 McNeil BJ, Keeler E, Adelstein SJ. Primer on certain elements of medical decision making. N Engl J Med 1975; 293: 211-215
    CrossrefPubMedGoogle Scholar
  • 13 Metz CE. Basic priciples of ROC analysis. Semin Nucl Med 1978; 8: 283-298
    CrossrefPubMedGoogle Scholar
  • 14 Turner DA. An intuitive approach to receiver operating characteristic curve analysis. J Nucl Med 1978; 19: 213-220
    PubMedGoogle Scholar
  • 15 Jorgensen KA, Dyerberg J, Olesen AS, Stoffersen E. Acetylsalicylic acid, bleeding time and age. Thromb Res 1980; 19: 799-805
    CrossrefPubMedGoogle Scholar
  • 16 Macpherson CR, Jacobs P. Bleeding time decreases with age. Arch Pathol Lab Med 1987; 111: 328-329
    PubMedGoogle Scholar
  • 17 Rodgers RPC, Levin J. A critical reappraisal of the bleeding time. Semin Thromb Hemostas 1990; 16: 1-20
    Artikel in Thieme ConnectPubMedGoogle Scholar
  • 18 Bain B, Forster T, Baker A. An assessment of the sensitivity of 3 bleeding time techniques. Scand J Haematol 1983; 30: 311-316
    PubMedGoogle Scholar
  • 19 Poller L, Thomson JM, Tomenson JA. The bleeding time: Current practice in the UK. Clin Lab Haematol 1984; 6: 369-373
    PubMedGoogle Scholar
  • 20 Macherel P, Sulzer I, Furlan M, Lammle B. Warning: Simplate II -Lack of standardization in standardized bleeding time devices. Thromb Haemostas 1990; 64: 605
    PubMedGoogle Scholar