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Thromb Haemost 1992; 67(02): 200-202
DOI: 10.1055/s-0038-1648412
Original Articles
Schattauer GmbH Stuttgart

Markers of Procoagulant Imbalance in Patients with Inherited Thrombophilic Syndromes

P M Mannucci
A. Bianchi Bonomi Hemophilia and Thrombosis Center and Institute of Internal Medicine, IRCCS Maggiore Hospital and University of Milano; Hematology Departments, Niguarda Cà Granda Hospital of Milano, Maggiore Hospital of Bergamo; Catholic University and State University of Rome; Angiology and Blood Coagulation Department, University of Bologna; 6th Division of Internal Medicine, Hospitals of Parma; Hemophilia and Thrombosis Center and Hematology Department, Vicenza, Italy
,
A Tripodi
A. Bianchi Bonomi Hemophilia and Thrombosis Center and Institute of Internal Medicine, IRCCS Maggiore Hospital and University of Milano; Hematology Departments, Niguarda Cà Granda Hospital of Milano, Maggiore Hospital of Bergamo; Catholic University and State University of Rome; Angiology and Blood Coagulation Department, University of Bologna; 6th Division of Internal Medicine, Hospitals of Parma; Hemophilia and Thrombosis Center and Hematology Department, Vicenza, Italy
,
B Bottasso
A. Bianchi Bonomi Hemophilia and Thrombosis Center and Institute of Internal Medicine, IRCCS Maggiore Hospital and University of Milano; Hematology Departments, Niguarda Cà Granda Hospital of Milano, Maggiore Hospital of Bergamo; Catholic University and State University of Rome; Angiology and Blood Coagulation Department, University of Bologna; 6th Division of Internal Medicine, Hospitals of Parma; Hemophilia and Thrombosis Center and Hematology Department, Vicenza, Italy
,
F Baudo
A. Bianchi Bonomi Hemophilia and Thrombosis Center and Institute of Internal Medicine, IRCCS Maggiore Hospital and University of Milano; Hematology Departments, Niguarda Cà Granda Hospital of Milano, Maggiore Hospital of Bergamo; Catholic University and State University of Rome; Angiology and Blood Coagulation Department, University of Bologna; 6th Division of Internal Medicine, Hospitals of Parma; Hemophilia and Thrombosis Center and Hematology Department, Vicenza, Italy
,
G Finazzi
A. Bianchi Bonomi Hemophilia and Thrombosis Center and Institute of Internal Medicine, IRCCS Maggiore Hospital and University of Milano; Hematology Departments, Niguarda Cà Granda Hospital of Milano, Maggiore Hospital of Bergamo; Catholic University and State University of Rome; Angiology and Blood Coagulation Department, University of Bologna; 6th Division of Internal Medicine, Hospitals of Parma; Hemophilia and Thrombosis Center and Hematology Department, Vicenza, Italy
,
V De Stefano
A. Bianchi Bonomi Hemophilia and Thrombosis Center and Institute of Internal Medicine, IRCCS Maggiore Hospital and University of Milano; Hematology Departments, Niguarda Cà Granda Hospital of Milano, Maggiore Hospital of Bergamo; Catholic University and State University of Rome; Angiology and Blood Coagulation Department, University of Bologna; 6th Division of Internal Medicine, Hospitals of Parma; Hemophilia and Thrombosis Center and Hematology Department, Vicenza, Italy
,
G Palareti
A. Bianchi Bonomi Hemophilia and Thrombosis Center and Institute of Internal Medicine, IRCCS Maggiore Hospital and University of Milano; Hematology Departments, Niguarda Cà Granda Hospital of Milano, Maggiore Hospital of Bergamo; Catholic University and State University of Rome; Angiology and Blood Coagulation Department, University of Bologna; 6th Division of Internal Medicine, Hospitals of Parma; Hemophilia and Thrombosis Center and Hematology Department, Vicenza, Italy
,
C Manotti
A. Bianchi Bonomi Hemophilia and Thrombosis Center and Institute of Internal Medicine, IRCCS Maggiore Hospital and University of Milano; Hematology Departments, Niguarda Cà Granda Hospital of Milano, Maggiore Hospital of Bergamo; Catholic University and State University of Rome; Angiology and Blood Coagulation Department, University of Bologna; 6th Division of Internal Medicine, Hospitals of Parma; Hemophilia and Thrombosis Center and Hematology Department, Vicenza, Italy
,
M G Mazzucconi
A. Bianchi Bonomi Hemophilia and Thrombosis Center and Institute of Internal Medicine, IRCCS Maggiore Hospital and University of Milano; Hematology Departments, Niguarda Cà Granda Hospital of Milano, Maggiore Hospital of Bergamo; Catholic University and State University of Rome; Angiology and Blood Coagulation Department, University of Bologna; 6th Division of Internal Medicine, Hospitals of Parma; Hemophilia and Thrombosis Center and Hematology Department, Vicenza, Italy
,
G Castaman
A. Bianchi Bonomi Hemophilia and Thrombosis Center and Institute of Internal Medicine, IRCCS Maggiore Hospital and University of Milano; Hematology Departments, Niguarda Cà Granda Hospital of Milano, Maggiore Hospital of Bergamo; Catholic University and State University of Rome; Angiology and Blood Coagulation Department, University of Bologna; 6th Division of Internal Medicine, Hospitals of Parma; Hemophilia and Thrombosis Center and Hematology Department, Vicenza, Italy
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Publikationsverlauf

Received 01. Mai 1991

Accepted after revision 05. September 1991

Publikationsdatum:
02. Juli 2018 (online)

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Summary

In 107 asymptomatic and untreated patients with inherited syndromes associated with thrombophilia (antithrombin III, protein C and protein S deficiencies), we compared in parallel two plasma peptides which reflect activation of the common coagulation pathway: the prothrombin fragment 1 + 2 (F1+2) and fibrinopeptide A (FPA). Both F1+2 and FPA were measured with simple, commercially available ELISA methods. High levels of F1+2 or FPA were found in about one fourth of the patients as a whole. When patients were divided according to the type of inherited thrombophilie syndrome, it appeared that F1+2 was more frequently elevated in protein C and protein S deficiencies than in antithrombin deficiency; and that, in general, it was no more frequently elevated than FPA. Although our data confirm the existence of a procoagulant imbalance in inherited thrombophilie syndromes due to defects of natural anticoagulant proteins, they do not confirm that such imbalance can be more frequently diagnosed by measuring F1+2 levels, particularly in patients with antithrombin deficiency.

 

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