Thromb Haemost 1991; 65(04): 377-381
DOI: 10.1055/s-0038-1648156
Original Article
Schattauer GmbH Stuttgart

Antithrombotic Activity of a Novel C-Terminal Hirudin Analog in Experimental Animals

R J Broersma
Merrell Dow Research Institute, Indianapolis, IN, USA
,
L W Kutcher
Merrell Dow Research Institute, Indianapolis, IN, USA
,
E F Heminger
Merrell Dow Research Institute, Indianapolis, IN, USA
,
J L Krstenansky
*  Merrell Dow Research Institute, Cincinnati, OH, USA
,
F N Marshall
Merrell Dow Research Institute, Indianapolis, IN, USA
› Author Affiliations
Further Information

Publication History

Received: 13 July 1989

Accepted after revision 11 December 1990

Publication Date:
02 July 2018 (online)

Summary

A synthetic hirudinsgs55-65 C-terminal fragment analog was evaluated for anticoagulant activity and in models of experimental thrombosis in mice and rats. Intravenous injection caused doserelated inhibition of thrombin and anticoagulation in rat blood samples, protection from thromboembolism in mice and inhibition of stasis-induced venous thrombosis in rats. Antithrombotic effectiveness corresponded with anticoagulant activity. Anephric animals exhibited longer duration of activity than normal animals suggesting the kidney as a major route of elimination.