Thromb Haemost 1991; 65(04): 374-376
DOI: 10.1055/s-0038-1648155
Original Article
Schattauer GmbH Stuttgart

Changes in Endothelial-Related Goagulation Proteins in Response to Venous Occlusion

I Jennings
The Department of Haematology, Addenbrookes Hospital, Cambridge, UK
,
R J Luddington
The Department of Haematology, Addenbrookes Hospital, Cambridge, UK
,
P L Harper
The Department of Haematology, Addenbrookes Hospital, Cambridge, UK
› Author Affiliations
Further Information

Publication History

Received: 22 March 1990

Accepted after revision 10 December 1990

Publication Date:
02 July 2018 (online)

Summary

One hundred patients with a history of thrombophilia wer divided into two groups based on fibrinolytic response to venous occlusion. Good responders with a euglobulin clot lysis time ≤ 105 min showed significant release of tPA, PAI and vWE Of the poor responders with an ECIX > 105 min, 24% showed a subnormal increase in tPA, and a significant proportion of these also showed a reduced or absent rise in vWE

We have shown poor fibrinolytic response was related to either raised levels of PAI, poor release of both tPA and vWR or poor release of tPA or vWF alone suggesting different mechanisms of fibrinolytic impairment. Protein S levels were not significantly changed in either group following occlusion.