Thromb Haemost 1991; 65(04): 335-338
DOI: 10.1055/s-0038-1648147
Original Article
Schattauer GmbH Stuttgart

Immunocytochemical Study on Endothelial Markers with the Cerebral Vessel from a Patient with Familial Moyamoya Disease

Fusako Usuki
1  The Third Department of Internal Medicine, Faculty of Medicine, Kagoshima University, Kagoshima, Japan
3  The Sakimoto Hospital, Kagoshima, Japan
,
Haruo Ohtani
2  The Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
,
Toshihide Okadome
1  The Third Department of Internal Medicine, Faculty of Medicine, Kagoshima University, Kagoshima, Japan
,
Koichi Shinmyozu
1  The Third Department of Internal Medicine, Faculty of Medicine, Kagoshima University, Kagoshima, Japan
,
Ikuro Maruyama
1  The Third Department of Internal Medicine, Faculty of Medicine, Kagoshima University, Kagoshima, Japan
,
Tetsuro Sakimoto
3  The Sakimoto Hospital, Kagoshima, Japan
,
Masayuki Atsuji
4  The Atsuli Hospital of Neurosurgery, Kagoshima, Japan
,
Mitsuhiro Osame
1  The Third Department of Internal Medicine, Faculty of Medicine, Kagoshima University, Kagoshima, Japan
› Author Affiliations
Further Information

Publication History

Received: 25 July 1990

Accepted after revision 23 November 1990

Publication Date:
02 July 2018 (online)

Summary

The immunocytochemical study of thrombomodulin (TM), a newly recognued anticoagulant endothelial surface protein, was performed with a surgical specimen of a superficial temporalartery (STA) obtained from a 29-year-old woman with familial moyamoya disease. The staining of TM showed positive immunoreactivity in smaller vessels in the surrounding connective tissue of the specimen, whereas negative in STA. Immunoelectronmicroscopically the luminal plasma membrane of endothelial cells was positive for TM. These staining pattern was the same as that in controls. She concurrently suffered from von Willebrand disease type I, and she had two cerebral hemorrhagic attacks. A quantitative defect of the von Willebrand factor in the endothelium was demonstrated immunocytochemically.