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Thromb Haemost 1976; 35(03): 570-575
DOI: 10.1055/s-0038-1647999
Original Article
Schattauer GmbH

Hageman Factor: its Structure and Modes of Activation[*]

S. D Revak
1   Department of Immunopathology, Scripps Clinic and Research Foundation, 476 Prospect Street, La Jolla, CA 92037
,
C. G Cochrane
1   Department of Immunopathology, Scripps Clinic and Research Foundation, 476 Prospect Street, La Jolla, CA 92037
› Author Affiliations
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Publication History

Publication Date:
02 July 2018 (online)

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* Presented at the National Conference on Thrombosis and Hemostasis, under the auspices of the Council on Thrombosis of the American Heart Association, Dallas, Texas, November 1974.


 
  • 1 Cochrane C. G, and Wuepper K. D. 1971; The first component of the kinin-forming system in human and rabbit plasma. Its relationship to clotting factor XII (Hageman factor). Journal of Experimental Medicine 134: 986.
    CrossrefPubMedGoogle Scholar
  • 2 Cochrane C. G, Revak S. D, Aikin B. S, and Wuepper K. D. 1972. The structural characteristics and activation of Hageman factor. In: Lepow and Ward (eds) Inflammation: Mechanisms and Control. Academic Press; New York: 119.
    Google Scholar
  • 3 Cochrane C. G, Revak S. D, and Wuepper K. D. 1973; Activation of Hageman factor in solid and fluid phases. Journal of Experimental Medicine 138: 1564.
    CrossrefPubMedGoogle Scholar
  • 4 Colman R. W, and Kaplan A. P. 1974 Discussion following presentation of A. P. Kaplan at Xth International Conference on the Chemistry and Biology of the Kallikrein - Kinin System in Health and Disease held in Reston, VA . October 20-23 1974
    PubMedGoogle Scholar
  • 5 Iatridis S. G, and Ferguson J. H. 1962; Active Hageman factor: a plasma lysokinase of the human fibrinolytic system. Journal of Clinical Investigation 41: 1211.
    CrossrefPubMedGoogle Scholar
  • 6 Johnston A. R, Cochrane C. G, and Revak S. D. 1974; The relationship between PF/dil and activated human Hageman factor. Journal of Immunology 113: 103.
    PubMedGoogle Scholar
  • 7 Kaplan A. P, and Austen K. F. 1972; The fibrinolytic pathway of human plasma: isolation and characterization of the plasminogen proactivator. Journal of Experimental Medicine 136: 1378.
    CrossrefPubMedGoogle Scholar
  • 8 Margolis J. 1958; Activation of plasma by contact with glass: evidence of a common reaction which releases plasma kinin and initiates coagulation. Journal of Physiology (London) 144: 1.
    PubMedGoogle Scholar
  • 9 Morrison D. C, and Cochrane C. G. 1974; Direct evidence for Hageman factor (Factor XII) activation by bacterial lipopolysaccharides (endotoxins). Journal of Experimental Medicine 140: 191.
    PubMedGoogle Scholar
  • 10 Ratnoff O. D, and Rosenblum J. M. 1958; Role of Hageman factor in the initiation of clotting by glass. Evidence that glass frees Hageman factor from inhibition. American Journal of Medicine 25: 160.
    PubMedGoogle Scholar
  • 11 Revak S. D, Cochrane C. G, Johnston A. R, and Hugli T. E. 1974; Structural changes accompanying enzymatic activation of human Hageman factor. Journal of Clinical Investigation 54: 619.
    CrossrefPubMedGoogle Scholar
  • 12 Revak S. D, and Cochrane C. G. 1976; The relationship of structure and function in human Hageman factor. The association of enzymatic and binding activities with separate regions of the molecule. Journal of Clinical Investigation 57: 852.
    CrossrefPubMedGoogle Scholar
  • 13 Wuepper K. D. 1972. Biochemistry and biology of components of the plasma kinin-forming system. In: Lepow and Ward (eds) Inflammation: Mechanisms and Control. Academic Press; New York: 93.
    Google Scholar
  • 14 Webster M. E, and Ratnoff O. D. 1961; Role of Hageman factor in the activation of vasodilator activity in human plasma. Nature (London) 192: 180.
    CrossrefPubMedGoogle Scholar