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DOI: 10.1055/s-0038-1647495
The Bleeding Time Is Inversely Related to Megakaryocyte Nuclear DNA Content and Size in Man
Publication History
Received 31 August 1987
Accepted after revision 04 January 1988
Publication Date:
29 June 2018 (online)
![](https://www.thieme-connect.de/media/10.1055-s-00035024/198803/lookinside/thumbnails/10-1055-s-0038-1647495-1.jpg)
Summary
The relation between the bleeding time and the megakaryocyte nuclear DNA content and size was evaluated in eleven consecutive patients with normal steady state thrombopoiesis undergoing thoracotomy. A statistically significant inverse correlation was found between the bleeding time and both megakaryocyte DNA content (r = −0.71, p <0.05), megakaryocyte total size (r = ‒0.58, p <0.05), megakaryocyte cytoplasmic size (r = −0.64, p <0.05) and megakaryocyte nuclear size (r = −0.58, p <0.05). The megakaryocyte total size and the megakaryocyte cytoplasmic size were statistically significantly larger in men than women (p <0.02 and p <0.03 respectively). Changes in the megakaryocytes in the bone marrow are associated with changes in primary haemostasis in normal individuals.
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