Thromb Haemost 1991; 65(01): 028-032
DOI: 10.1055/s-0038-1647449
Original Article
Schattauer GmbH Stuttgart

D-Dimers, Thrombin Antithrombin III Complexes and Prothrombin Fragments 1 + 2: Diagnostic value in Clinically Suspected Deep Vein Thrombosis

B Boneu
1   Laboratoire d’Hémostase, Centre de Transfusion Sanguine, Toulouse, France
,
G Bes
2   Unité d’Angiologie, Hôpital de Rangueil, Toulouse, France
,
H Pelzer
3   Department of Blood Coagulation, Behringwerke AG, Marburg, Germany
,
P Sié
1   Laboratoire d’Hémostase, Centre de Transfusion Sanguine, Toulouse, France
,
H Boccalon
2   Unité d’Angiologie, Hôpital de Rangueil, Toulouse, France
› Author Affiliations
Further Information

Publication History

Received 14 June 1990

Accepted after revision 21 August 1990

Publication Date:
02 July 2018 (online)

Summary

This study was performed to determine the accuracy of D-Dimer fibrin derivatives, thrombin-antithrombin III (TAT) complexes and prothrombin fragments 1 + 2 (F 1 + 2) determinations for the diagnosis of deep vein thrombosis (DVT). One hundred and sixteen consecutive patients referred to the angiology unit of our hospital for a clinically suspected DVT were investigated. They were submitted to mercury strain gauge plethysmography and to ultrasonic duplex scanning examination; in cases of inconclusive results or of proximal DVT (n = 35), an ascending phlebography was performed. After these investigations were completed, the diagnosis of DVT was confirmed in 34 and excluded in 82. One half of the patients were already under anticoagulant therapy at the time of investigation. The 3 biological markers were assayed using commercially available ELISA techniques and the D-Dimer was also assayed with a fast latex method. The normal distribution of these markers was established in 40 healthy blood donors. The most accurate assay for the diagnosis of DVT was the D-Dimer ELISA which had both a high sensitivity (94%) and a high negative predictive value (95%). The D-Dirner latex, TAT complexes and F 1 + 2 were far less sensitive and provided negative predictive values which ranged between 78 and 85%. In spite of positive and significant correlations between the levels of ihe 3 markers, their association did not improve their overall accuracy for detecting D\/L Therefore, with the exception of the D-Dimer ELISA, these markers were of little value for the diagnosis of DVT in this specific population.

 
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