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Thromb Haemost 1990; 64(02): 192-195
DOI: 10.1055/s-0038-1647283
Original Article
Schattauer GmbH Stuttgart

D-Dimer in Local Thrombolytic Therapy with Low Doses of Recombinant Human Tissue-Type Plasminogen Activator (rt-PA) in Patients with Peripheral Arterial Occlusive Disease

Renate Koppensteiner
The First Department of Medicine, Division of Angiolog, University of Vienna, Vienna, Austria
,
Wolfgang Speiser
*   The Division of Hematology and Hemostaseology, University of Vienna, Vienna, Austria
,
Erich Minar
The First Department of Medicine, Division of Angiolog, University of Vienna, Vienna, Austria
,
Ramazan Ahmadi
The First Department of Medicine, Division of Angiolog, University of Vienna, Vienna, Austria
,
Herbert Ehringer
The First Department of Medicine, Division of Angiolog, University of Vienna, Vienna, Austria
› Author Affiliations
Further Information

Publication History

Received 27 December 1989

Accepted after revision 20 April 1990

Publication Date:
25 July 2018 (online)

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Summary

The generation of D-dimer was studied in the course of local thrombolytic therapy of peripheral arterial occlusions with low doses of recombinant human tissue-type plasminogen activator (rt-PA) in 7 patients. Intermittent local application of rt-PA resulted in a marked increase in D-dimer exceeding values usually seen after intravenous application of manifold higher doses used in myocardial infarction. The increase in D-dimer was related to the estimated thrombus size (length of the occlusion) and the total dose of rt-PA applied. During local rt-PA infusion 6 of 7 patients maintained plasminogen activator inhibitor capacity (PAI-cap) between 34% and 79% of their corresponding pre-treatment levels; detectable levels of PAI-cap in circulating blood during the procedure did not interfere with the success of therapy.

 

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