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DOI: 10.1055/s-0038-1647247
Emerging Viral Infections and Their Impact on the Global Burden of Neurological Disease
Publikationsverlauf
Publikationsdatum:
23. Mai 2018 (online)
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Abstract
Emerging viral infections of the nervous system represent a major global public health concern in the 21st century. They are caused primarily by RNA viruses and are mostly associated with acute or subacute encephalitis. The spectrum of associated central or peripheral nervous system disorders is broad, and results either from a direct viral effect or due to the host immune responses against the infection. Emerging viral infections impose substantial neurological morbidity and mortality, particularly in low- and middle-income regions. In the past five decades, vector-borne viruses primarily transmitted by arthropods, or arboviruses, have been responsible for epidemics with a high burden of neurological disease, like the 2015–2016 Zika virus epidemic in the Americas. Viruses that have become neurovirulent for humans after geographical expansion include West Nile, Dengue, and Zika viruses. Factors such as animal migration, disruption of ecological niches, and cross-species contact have caused old viruses to reappear and cause neurological disease, as is the case of Ebola virus. In addition to these biological challenges, current preventive strategies, vaccination, and diagnostic and therapeutic approaches remain limited. We review the clinical-virological features and global impact of the most relevant emerging viral infections of the nervous system as they are projected over the 21st century.
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References
- 1 Medicine. FoMTBogHIo. Emerging Viral Diseases. Emerging Viral Diseases: The One Health Connection: Workshop Summary. The National Academies Collection: Reports funded by National Institutes of Health. Washington, DC: National Academies Press; 2015
- 2 Taylor LH, Latham SM, Woolhouse ME. Risk factors for human disease emergence. Philos Trans R Soc Lond B Biol Sci 2001; 356 (1411): 983-989
- 3 Koyuncu OO, Hogue IB, Enquist LW. Virus infections in the nervous system. Cell Host Microbe 2013; 13 (04) 379-393
- 4 Olival KJ, Daszak P. The ecology of emerging neurotropic viruses. J Neurovirol 2005; 11 (05) 441-446
- 5 NIAID. NIAID Emerging Infectious Diseases/Pathogens 2016 [updated October 26, 2016. Available at: https://www.niaid.nih.gov/research/emerging-infectious-diseases-pathogens . Accessed April 10, 2018
- 6 Knipe DM. Fields Virology. 6th ed. Philadelphia, PA: Wolters Kluwer Health; 2013
- 7 Holmes EC. What can we predict about viral evolution and emergence?. Curr Opin Virol 2013; 3 (02) 180-184
- 8 Parrish CR, Holmes EC, Morens DM. , et al. Cross-species virus transmission and the emergence of new epidemic diseases. Microbiol Mol Biol Rev 2008; 72 (03) 457-470
- 9 Dennehy JJ. Evolutionary ecology of virus emergence. Ann N Y Acad Sci 2017; 1389 (01) 124-146
- 10 Wolfe ND, Dunavan CP, Diamond J. Origins of major human infectious diseases. Nature 2007; 447 (7142): 279-283
- 11 Wilder-Smith A, Gubler DJ, Weaver SC, Monath TP, Heymann DL, Scott TW. Epidemic arboviral diseases: priorities for research and public health. Lancet Infect Dis 2017; 17 (03) e101-e106
- 12 Gould E, Pettersson J, Higgs S, Charrel R, de Lamballerie X. Emerging arboviruses: Why today?. One Health 2017; 4: 1-13
- 13 Dando SJ, Mackay-Sim A, Norton R. , et al. Pathogens penetrating the central nervous system: infection pathways and the cellular and molecular mechanisms of invasion. Clin Microbiol Rev 2014; 27 (04) 691-726
- 14 Kramer T, Enquist LW. Directional spread of alpha herpes viruses in the nervous system. Viruses 2013; 5 (02) 678-707
- 15 Solomon T, Lewthwaite P, Perera D, Cardosa MJ, McMinn P, Ooi MH. Virology, epidemiology, pathogenesis, and control of enterovirus 71. Lancet Infect Dis 2010; 10 (11) 778-790
- 16 Racaniello VR. One hundred years of poliovirus pathogenesis. Virology 2006; 344 (01) 9-16
- 17 Lafon M. Subversive neuroinvasive strategy of rabies virus. Arch Virol Suppl 2004; (18) 149-159
- 18 van Riel D, Verdijk R, Kuiken T. The olfactory nerve: a shortcut for influenza and other viral diseases into the central nervous system. J Pathol 2015; 235 (02) 277-287
- 19 Suthar MS, Diamond MS, Gale Jr M. West Nile virus infection and immunity. Nat Rev Microbiol 2013; 11 (02) 115-128
- 20 McGavern DB, Kang SS. Illuminating viral infections in the nervous system. Nat Rev Immunol 2011; 11 (05) 318-329
- 21 Gassmann M, Focher F, Buhk HJ, Ferrari E, Spadari S, Hübscher U. Replication of single-stranded porcine circovirus DNA by DNA polymerases alpha and delta. Biochim Biophys Acta 1988; 951 (2-3): 280-289
- 22 Li L, Kapoor A, Slikas B. , et al. Multiple diverse circoviruses infect farm animals and are commonly found in human and chimpanzee feces. J Virol 2010; 84 (04) 1674-1682
- 23 Smits SL, Zijlstra EE, van Hellemond JJ. , et al. Novel cyclovirus in human cerebrospinal fluid, Malawi, 2010-2011. Emerg Infect Dis 2013;19(9)
- 24 Tan V, van Doorn HR, Nghia HD. , et al. Identification of a new cyclovirus in cerebrospinal fluid of patients with acute central nervous system infections. MBio 2013; 4 (03) e00231-e13
- 25 Robinson MC. An epidemic of virus disease in Southern Province, Tanganyika Territory, in 1952-53. I. Clinical features. Trans R Soc Trop Med Hyg 1955; 49 (01) 28-32
- 26 Silva LA, Dermody TS. Chikungunya virus: epidemiology, replication, disease mechanisms, and prospective intervention strategies. J Clin Invest 2017; 127 (03) 737-749
- 27 Powers AM, Logue CH. Changing patterns of chikungunya virus: re-emergence of a zoonotic arbovirus. J Gen Virol 2007; 88 (Pt 9): 2363-2377
- 28 Suryawanshi SD, Dube AH, Khadse RK. , et al. Clinical profile of chikungunya fever in patients in a tertiary care centre in Maharashtra, India. Indian J Med Res 2009; 129 (04) 438-441
- 29 Chandak NH, Kashyap RS, Kabra D. , et al. Neurological complications of Chikungunya virus infection. Neurol India 2009; 57 (02) 177-180
- 30 Crosby L, Perreau C, Madeux B. , et al. Severe manifestations of chikungunya virus in critically ill patients during the 2013-2014 Caribbean outbreak. Int J Infect Dis 2016; 48: 78-80
- 31 Gérardin P, Couderc T, Bintner M. , et al; Encephalchik Study Group. Chikungunya virus-associated encephalitis: a cohort study on La Réunion Island, 2005-2009. Neurology 2016; 86 (01) 94-102
- 32 Gérardin P, Barau G, Michault A. , et al. Multidisciplinary prospective study of mother-to-child chikungunya virus infections on the island of La Réunion. PLoS Med 2008; 5 (03) e60
- 33 Burt FJ, Rolph MS, Rulli NE, Mahalingam S, Heise MT. Chikungunya: a re-emerging virus. Lancet 2012; 379 (9816): 662-671
- 34 Erasmus JH, Rossi SL, Weaver SC. Development of vaccines for chikungunya fever. J Infect Dis 2016; 214 (Suppl. 05) S488-S496
- 35 Holmes EC, Twiddy SS. The origin, emergence and evolutionary genetics of dengue virus. Infect Genet Evol 2003; 3 (01) 19-28
- 36 Bhatt S, Gething PW, Brady OJ. , et al. The global distribution and burden of dengue. Nature 2013; 496 (7446): 504-507
- 37 Stanaway JD, Shepard DS, Undurraga EA. , et al. The global burden of dengue: an analysis from the Global Burden of Disease Study 2013. Lancet Infect Dis 2016; 16 (06) 712-723
- 38 Sahu R, Verma R, Jain A. , et al. Neurologic complications in dengue virus infection: a prospective cohort study. Neurology 2014; 83 (18) 1601-1609
- 39 Domingues RB, Kuster GW, Onuki-Castro FL, Souza VA, Levi JE, Pannuti CS. Involvement of the central nervous system in patients with dengue virus infection. J Neurol Sci 2008; 267 (1-2): 36-40
- 40 Carod-Artal FJ, Wichmann O, Farrar J, Gascón J. Neurological complications of dengue virus infection. Lancet Neurol 2013; 12 (09) 906-919
- 41 Solomon T, Dung NM, Vaughn DW. , et al. Neurological manifestations of dengue infection. Lancet 2000; 355 (9209): 1053-1059
- 42 Soares CN, Faria LC, Peralta JM, de Freitas MR, Puccioni-Sohler M. Dengue infection: neurological manifestations and cerebrospinal fluid (CSF) analysis. J Neurol Sci 2006; 249 (01) 19-24
- 43 Wasay M, Channa R, Jumani M, Shabbir G, Azeemuddin M, Zafar A. Encephalitis and myelitis associated with dengue viral infection clinical and neuroimaging features. Clin Neurol Neurosurg 2008; 110 (06) 635-640
- 44 Bhoi SK, Naik S, Kumar S, Phadke RV, Kalita J, Misra UK. Cranial imaging findings in dengue virus infection. J Neurol Sci 2014; 342 (1-2): 36-41
- 45 Kunishige M, Mitsui T, Tan BH. , et al. Preferential gray matter involvement in dengue myelitis. Neurology 2004; 63 (10) 1980-1981
- 46 Seet RC, Lim EC, Wilder-Smith EP. Acute transverse myelitis following dengue virus infection. J Clin Virol 2006; 35 (03) 310-312
- 47 Simon O, Billot S, Guyon D. , et al. Early Guillain-Barré Syndrome associated with acute dengue fever. J Clin Virol 2016; 77: 29-31
- 48 WHO. Dengue: Guidelines for Diagnosis, Treatment, Prevention and Control: New Edition. Geneva; 2009
- 49 Verma R, Sahu R, Holla V. Neurological manifestations of dengue infection: a review. J Neurol Sci 2014; 346 (1-2): 26-34
- 50 Aguiar M, Stollenwerk N, Halstead SB. The impact of the newly licensed dengue vaccine in endemic countries. PLoS Negl Trop Dis 2016; 10 (12) e0005179
- 51 WHO. Updated Questions and Answers related to the dengue vaccine Dengvaxia® and its use 2017. Available at: http://www.who.int/immunization/diseases/dengue/q_and_a_dengue_vaccine_dengvaxia_use/en/ . Accessed April 10, 2018
- 52 Jonhson RT. Meningitis, Encephalitis, and Poliomyelitis. Viral Infections of the Nervous System. 2nd ed. Philadelphia, PA: Lippincott-Raven Publishers; 1998
- 53 Miles JA, Chir B, Fowler MC, Howes DW. Isolation of a virus from encephalitis in South Australia: a preliminary report. Med J Aust 1951; 1 (22) 799-800
- 54 Mackenzie JS, Lindsay MD, Coelen RJ, Broom AK, Hall RA, Smith DW. Arboviruses causing human disease in the Australasian zoogeographic region. Arch Virol 1994; 136 (3-4): 447-467
- 55 Group NARW. ; NNDSS Annual Report Writing Group. Australia's notifiable disease status, 2013: Annual report of the National Notifiable Diseases Surveillance System. Commun Dis Intell Q Rep 2015; 39 (03) E387-E478
- 56 Selvey LA, Dailey L, Lindsay M. , et al. The changing epidemiology of Murray Valley encephalitis in Australia: the 2011 outbreak and a review of the literature. PLoS Negl Trop Dis 2014; 8 (01) e2656
- 57 Knox J, Cowan RU, Doyle JS. , et al. Murray Valley encephalitis: a review of clinical features, diagnosis and treatment. Med J Aust 2012; 196 (05) 322-326
- 58 Burrow JN, Whelan PI, Kilburn CJ, Fisher DA, Currie BJ, Smith DW. Australian encephalitis in the Northern Territory: clinical and epidemiological features, 1987-1996. Aust N Z J Med 1998; 28 (05) 590-596
- 59 Wong SH, Smith DW, Fallon MJ, Kermode AG. Murray valley encephalitis mimicking herpes simplex encephalitis. J Clin Neurosci 2005; 12 (07) 822-824
- 60 Hall RA, Broom AK, Hartnett AC, Howard MJ, Mackenzie JS. Immunodominant epitopes on the NS1 protein of MVE and KUN viruses serve as targets for a blocking ELISA to detect virus-specific antibodies in sentinel animal serum. J Virol Methods 1995; 51 (2-3): 201-210
- 61 Lyons J, McArthur J. Emerging infections of the central nervous system. Curr Infect Dis Rep 2013; 15 (06) 576-582
- 62 Smithburn KC, Hughes TP, Burke AW. , et al. A neurotropic virus isolated from the blood of a native of Uganda. Am J Trop Med 1940; 20: 471-472
- 63 Hayes CG. West Nile virus: Uganda, 1937, to New York City, 1999. Ann N Y Acad Sci 2001; 951: 25-37
- 64 Ceauşu E, Erşcoiu S, Calistru P. , et al. Clinical manifestations in the West Nile virus outbreak. Rom J Virol 1997; 48 (1-4): 3-11
- 65 Platonov AE, Shipulin GA, Shipulina OY. , et al. Outbreak of West Nile virus infection, Volgograd Region, Russia, 1999. Emerg Infect Dis 2001; 7 (01) 128-132
- 66 Nash D, Mostashari F, Fine A. , et al; 1999 West Nile Outbreak Response Working Group. The outbreak of West Nile virus infection in the New York City area in 1999. N Engl J Med 2001; 344 (24) 1807-1814
- 67 Chancey C, Grinev A, Volkova E, Rios M. The global ecology and epidemiology of West Nile virus. BioMed Res Int 2015; 2015 (15) 376230
- 68 Petersen LR, Brault AC, Nasci RS. West Nile virus: review of the literature. JAMA 2013; 310 (03) 308-315
- 69 Lindsey NP, Staples JE, Lehman JA, Fischer M. ; Centers for Disease Control and Prevention (CDC). Surveillance for human West Nile virus disease - United States, 1999-2008. MMWR Surveill Summ 2010; 59 (02) 1-17
- 70 Sejvar JJ. West Nile virus infection. Microbiol Spectr 2016;4(3)
- 71 Sejvar JJ. Clinical manifestations and outcomes of West Nile virus infection. Viruses 2014; 6 (02) 606-623
- 72 Debiasi RL, Tyler KL. West Nile virus meningoencephalitis. Nat Clin Pract Neurol 2006; 2 (05) 264-275
- 73 Kanagarajan K, Ganesh S, Alakhras M, Go ES, Recco RA, Zaman MM. West Nile virus infection presenting as cerebellar ataxia and fever: case report. South Med J 2003; 96 (06) 600-601
- 74 Sayao AL, Suchowersky O, Al-Khathaami A. , et al. Calgary experience with West Nile virus neurological syndrome during the late summer of 2003. Can J Neurol Sci 2004; 31 (02) 194-203
- 75 Brilla R, Block M, Geremia G, Wichter M. Clinical and neuroradiologic features of 39 consecutive cases of West Nile Virus meningoencephalitis. J Neurol Sci 2004; 220 (1-2): 37-40
- 76 Sejvar JJ, Leis AA, Stokic DS. , et al. Acute flaccid paralysis and West Nile virus infection. Emerg Infect Dis 2003; 9 (07) 788-793
- 77 Li J, Loeb JA, Shy ME. , et al. Asymmetric flaccid paralysis: a neuromuscular presentation of West Nile virus infection. Ann Neurol 2003; 53 (06) 703-710
- 78 Leis AA, Stokic DS. Neuromuscular manifestations of West Nile virus infection. Front Neurol 2012; 3: 37
- 79 Samaan Z, McDermid Vaz S, Bawor M, Potter TH, Eskandarian S, Loeb M. Neuropsychological impact of West Nile virus infection: an extensive neuropsychiatric assessment of 49 cases in Canada. PLoS One 2016; 11 (06) e0158364
- 80 Tilley PA, Fox JD, Jayaraman GC, Preiksaitis JK. Nucleic acid testing for West Nile virus RNA in plasma enhances rapid diagnosis of acute infection in symptomatic patients. J Infect Dis 2006; 193 (10) 1361-1364
- 81 Suen WW, Prow NA, Hall RA, Bielefeldt-Ohmann H. Mechanism of West Nile virus neuroinvasion: a critical appraisal. Viruses 2014; 6 (07) 2796-2825
- 82 Chowers MY, Lang R, Nassar F. , et al. Clinical characteristics of the West Nile fever outbreak, Israel, 2000. Emerg Infect Dis 2001; 7 (04) 675-678
- 83 Dick GWKS, Kitchen SF, Haddow AJ. Zika virus. I. Isolations and serological specificity. Trans R Soc Trop Med Hyg 1952; 46 (05) 509-520
- 84 GW. D. Zika virus, II: pathogenicity and physical properties. Trans R Soc Trop Med Hyg 1952; 46 (05) 521-534
- 85 Duffy MR, Chen TH, Hancock WT. , et al. Zika virus outbreak on Yap Island, Federated States of Micronesia. N Engl J Med 2009; 360 (24) 2536-2543
- 86 WHO/PAHO. Regional Zika Epidemiological Update (Americas) May 25, 2017 Zika Resources 2017. Available at: http://www.paho.org/hq/index.php?option=com_content&id=11599&Itemid=41691 . Accessed April 10, 2018
- 87 Beckham JD, Pastula DM, Massey A, Tyler KL. Zika virus as an emerging global pathogen: neurological complications of Zika virus. JAMA Neurol 2016; 73 (07) 875-879
- 88 Dos Santos T, Rodriguez A, Almiron M. , et al. Zika virus and the Guillain-Barré syndrome - case series from seven countries. N Engl J Med 2016; 375 (16) 1598-1601
- 89 Mlakar J, Korva M, Tul N. , et al. Zika virus associated with microcephaly. N Engl J Med 2016; 374 (10) 951-958
- 90 Parra B, Lizarazo J, Jiménez-Arango JA. , et al. Guillain-Barré syndrome associated with Zika virus infection in Colombia. N Engl J Med 2016; 375 (16) 1513-1523
- 91 Dirlikov E, Major CG, Mayshack M. , et al. Guillain-Barré syndrome during ongoing Zika virus transmission - Puerto Rico, January 1-July 31, 2016. MMWR Morb Mortal Wkly Rep 2016; 65 (34) 910-914
- 92 Cao-Lormeau VM, Roche C, Teissier A. , et al. Zika virus, French Polynesia, South pacific, 2013. Emerg Infect Dis 2014; 20 (06) 1085-1086
- 93 Carteaux G, Maquart M, Bedet A. , et al. Zika virus associated with meningoencephalitis. N Engl J Med 2016; 374 (16) 1595-1596
- 94 Mécharles S, Herrmann C, Poullain P. , et al. Acute myelitis due to Zika virus infection. Lancet 2016; 387 (10026): 1481
- 95 Muñoz LS, Parra B, Pardo CA. Neuroviruses Emerging in the Americas Study. Neurological implications of Zika virus infection in adults. J Infect Dis 2017; 216 (10) 897-905
- 96 Petersen LR, Jamieson DJ, Honein MA. Zika virus. N Engl J Med 2016; 375 (03) 294-295
- 97 WHO. Efficacy trials of ZIKV Vaccines: endpoints, trial design, site selection: June 1–2, 2017 2017. Available at: http://www.who.int/blueprint/what/norms-standards/ZIKV_final_report_public_version.pdf?ua=1 . Accessed April 10, 2018
- 98 Huang HI, Shih SR. Neurotropic enterovirus infections in the central nervous system. Viruses 2015; 7 (11) 6051-6066
- 99 Schmidt NJ, Lennette EH, Ho HH. An apparently new enterovirus isolated from patients with disease of the central nervous system. J Infect Dis 1974; 129 (03) 304-309
- 100 Huang CC, Liu CC, Chang YC, Chen CY, Wang ST, Yeh TF. Neurologic complications in children with enterovirus 71 infection. N Engl J Med 1999; 341 (13) 936-942
- 101 Shen WC, Chiu HH, Chow KC, Tsai CH. MR imaging findings of enteroviral encephaloymelitis: an outbreak in Taiwan. AJNR Am J Neuroradiol 1999; 20 (10) 1889-1895
- 102 Liu K, Ma YX, Zhang CB. , et al. Neurologic complications in children with enterovirus 71-infected hand-foot-mouth disease : clinical features, MRI findings and follow-up study [Chinese]. Zhonghua Yi Xue Za Zhi 2012; 92 (25) 1742-1746
- 103 Pérez-Vélez CM, Anderson MS, Robinson CC. , et al. Outbreak of neurologic enterovirus type 71 disease: a diagnostic challenge. Clin Infect Dis 2007; 45 (08) 950-957
- 104 Sejvar JJ, Lopez AS, Cortese MM. , et al. Acute flaccid myelitis in the United States, August-December 2014: results of nationwide surveillance. Clin Infect Dis 2016; 63 (06) 737-745
- 105 CDC. Non-Polio Enterovirus 2016. Available at: https://www.cdc.gov/non-polio-enterovirus/lab-testing/specimen-collection.html . Accessed April 10, 2018
- 106 World Health Organization. Rift Valley fever WHO Media Center 2016. Available at: http://www.who.int/mediacentre/factsheets/fs207/en/ . Accessed April 10, 2018
- 107 Ikegami T, Makino S. The pathogenesis of Rift Valley fever. Viruses 2011; 3 (05) 493-519
- 108 Mandell RB, Flick R. Rift Valley fever virus: an unrecognized emerging threat?. Hum Vaccin 2010; 6 (07) 597-601
- 109 Madani TA, Al-Mazrou YY, Al-Jeffri MH. , et al. Rift Valley fever epidemic in Saudi Arabia: epidemiological, clinical, and laboratory characteristics. Clin Infect Dis 2003; 37 (08) 1084-1092
- 110 Gonzales-Scarano F. The Bunyaviridae. In: Tselis AC, Booss J. , eds. Handbook of Clinical Neurology, Neurovirology. Amsterdam, Netherlands: Elsevier; 2014: 123
- 111 Alrajhi AA, Al-Semari A, Al-Watban J. Rift Valley fever encephalitis. Emerg Infect Dis 2004; 10 (03) 554-555
- 112 Mansfield KL, Banyard AC, McElhinney L. , et al. Rift Valley fever virus: a review of diagnosis and vaccination, and implications for emergence in Europe. Vaccine 2015; 33 (42) 5520-5531
- 113 Eldridge BF, Glaser C, Pedrin RE, Chiles RE. The first reported case of California encephalitis in more than 50 years. Emerg Infect Dis 2001; 7 (03) 451-452
- 114 Thompson WH, Kalfayan B, Anslow RO. Isolation of California Encephalitis Group virus from a fatal human illness. Am J Epidemiol 1965; 81: 245-253
- 115 Centers for Disease Control and Prevention (CDC). La Crosse virus neuroinvasive disease - Missouri, 2009. MMWR Morb Mortal Wkly Rep 2010; 59 (28) 869-871
- 116 Prevention CfDCa. La Crosse Encephalitis 2016. Available at: https://www.cdc.gov/lac/tech/epi.html . Accessed April 10, 2018
- 117 Taylor KG, Peterson KE. Innate immune response to La Crosse virus infection. J Neurovirol 2014; 20 (02) 150-156
- 118 McJunkin JE, de los Reyes EC, Irazuzta JE. , et al. La Crosse encephalitis in children. N Engl J Med 2001; 344 (11) 801-807
- 119 Teleron AL, Rose BK, Williams DM, Kemper SE, McJunkin JE. La Crosse encephalitis: an adult case series. Am J Med 2016; 129 (08) 881-884
- 120 Balfour Jr HH, Siem RA, Bauer H, Quie PG. California arbovirus (La Crosse) infections. I. Clinical and laboratory findings in 66 children with meningoencephalitis. Pediatrics 1973; 52 (05) 680-691
- 121 Breman JG, Heymann DL, Lloyd G. , et al. Discovery and description of Ebola Zaire virus in 1976 and relevance to the West African Epidemic during 2013-2016. J Infect Dis 2016; 214 (Suppl. 03) S93-S101
- 122 Billioux BJ. Neurological complications and sequelae of Ebola virus disease. Curr Infect Dis Rep 2017; 19 (05) 19
- 123 Rewar S, Mirdha D. Transmission of Ebola virus disease: an overview. Ann Glob Health 2014; 80 (06) 444-451
- 124 Billioux B, Bowen L, Smith B. , et al. Accounts from Liberia: Reports of Neurological Manifestations During the Acute Phase of Ebola Virus Disease (P1.283). American Academy of Neurology; 2015
- 125 Dhillon P, McCarthy S, Gibbs M. Surviving stroke in an Ebola Treatment Centre. BMJ Case Rep 2015; 2015 (15) bcr2015211062
- 126 Howlett P, Brown C, Helderman T. , et al. Ebola virus disease complicated by late-onset encephalitis and polyarthritis, Sierra Leone. Emerg Infect Dis 2016; 22 (01) 150-152
- 127 Chertow DS, Nath A, Suffredini AF. , et al. Severe meningoencephalitis in a case of Ebola virus disease: a case report. Ann Intern Med 2016; 165 (04) 301-304
- 128 Clark DV, Kibuuka H, Millard M. , et al. Long-term sequelae after Ebola virus disease in Bundibugyo, Uganda: a retrospective cohort study. Lancet Infect Dis 2015; 15 (08) 905-912
- 129 Tiffany A, Vetter P, Mattia J. , et al. Ebola virus disease complications as experienced by survivors in Sierra Leone. Clin Infect Dis 2016; 62 (11) 1360-1366
- 130 Martin P, Laupland KB, Frost EH, Valiquette L. Laboratory diagnosis of Ebola virus disease. Intensive Care Med 2015; 41 (05) 895-898
- 131 Abdullah S, Tan CT. Henipavirus encephalitis. Handb Clin Neurol 2014; 123: 663-670
- 132 Broder CC. Henipavirus outbreaks to antivirals: the current status of potential therapeutics. Curr Opin Virol 2012; 2 (02) 176-187
- 133 Goh KJ, Tan CT, Chew NK. , et al. Clinical features of Nipah virus encephalitis among pig farmers in Malaysia. N Engl J Med 2000; 342 (17) 1229-1235
- 134 Ong KC, Wong KT. Henipavirus encephalitis: recent developments and advances. Brain Pathol 2015; 25 (05) 605-613
- 135 Petrova VN, Russell CA. The evolution of seasonal influenza viruses. Nat Rev Microbiol 2018; 16 (01) 47-60
- 136 Ekstrand JJ. Neurologic complications of influenza. Semin Pediatr Neurol 2012; 19 (03) 96-100
- 137 Tsai JP, Baker AJ. Influenza-associated neurological complications. Neurocrit Care 2013; 18 (01) 118-130
- 138 Ekstrand JJ, Herbener A, Rawlings J. , et al. Heightened neurologic complications in children with pandemic H1N1 influenza. Ann Neurol 2010; 68 (05) 762-766
- 139 Okumura A, Nakagawa S, Kawashima H. , et al. Deaths associated with pandemic (H1N1) 2009 among children, Japan, 2009-2010. Emerg Infect Dis 2011; 17 (11) 1993-2000
- 140 Neilson DE. The interplay of infection and genetics in acute necrotizing encephalopathy. Curr Opin Pediatr 2010; 22 (06) 751-757
- 141 Lee N, Wong CK, Chan PK. , et al. Acute encephalopathy associated with influenza A infection in adults. Emerg Infect Dis 2010; 16 (01) 139-142
- 142 CDC. Prevention and Control of Seasonal Influenza with Vaccines: Recommendations of the Advisory Committee on Immunization Practices—United States, 2017–18 Influenza Season 2017. Available at: https://www.cdc.gov/mmwr/volumes/66/rr/rr6602a1.htm . Accessed April 10, 2018
- 143 WHO. Rabies: Epidemiology and burden of disease 2017. Available at: http://www.who.int/rabies/epidemiology/en/ . Accessed April 10, 2018
- 144 WHO. Human rabies: 2016 updates and call for data 2016. Available at: http://apps.who.int/iris/bitstream/10665/254622/2/WER9207.pdf?ua=1 . Accessed April 10, 2018
- 145 Hampson K, Coudeville L, Lembo T. , et al; Global Alliance for Rabies Control Partners for Rabies Prevention. Estimating the global burden of endemic canine rabies. PLoS Negl Trop Dis 2015; 9 (04) e0003709
- 146 Willoughby Jr RE. Rabies: rare human infection - common questions. Infect Dis Clin North Am 2015; 29 (04) 637-650
- 147 Hemachudha T, Ugolini G, Wacharapluesadee S, Sungkarat W, Shuangshoti S, Laothamatas J. Human rabies: neuropathogenesis, diagnosis, and management. Lancet Neurol 2013; 12 (05) 498-513
- 148 Laothamatas J, Hemachudha T, Mitrabhakdi E, Wannakrairot P, Tulayadaechanont S. MR imaging in human rabies. AJNR Am J Neuroradiol 2003; 24 (06) 1102-1109
- 149 Goldsmith CS, Ksiazek TG, Rollin PE. , et al. Cell culture and electron microscopy for identifying viruses in diseases of unknown cause. Emerg Infect Dis 2013; 19 (06) 886-891
- 150 Hazelton PR, Gelderblom HR. Electron microscopy for rapid diagnosis of infectious agents in emergent situations. Emerg Infect Dis 2003; 9 (03) 294-303
- 151 Laine RF, Albecka A, van de Linde S, Rees EJ, Crump CM, Kaminski CF. Structural analysis of herpes simplex virus by optical super-resolution imaging. Nat Commun 2015; 6: 5980
- 152 Ratnam S, Gadag V, West R. , et al. Comparison of commercial enzyme immunoassay kits with plaque reduction neutralization test for detection of measles virus antibody. J Clin Microbiol 1995; 33 (04) 811-815
- 153 Lecuit M, Eloit M. The diagnosis of infectious diseases by whole genome next generation sequencing: a new era is opening. Front Cell Infect Microbiol 2014; 4: 25
- 154 Salzberg SL, Breitwieser FP, Kumar A. , et al. Next-generation sequencing in neuropathologic diagnosis of infections of the nervous system. Neurol Neuroimmunol Neuroinflamm 2016; 3 (04) e251
- 155 Houldcroft CJ, Beale MA, Breuer J. Clinical and biological insights from viral genome sequencing. Nat Rev Microbiol 2017; 15 (03) 183-192