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Thromb Haemost 1988; 60(02): 205-208
DOI: 10.1055/s-0038-1647030
Original Article
Schattauer GmbH Stuttgart

Evidence for an Increased Generation of Prostacyclin in the Microvasculature and an Impairment of the Platelet α-Granule Release in Chronic Renal Failure

Paul A Kyrle
The Department of Medicine I, Division of Haematology and Blood Coagulation and Division of Nephrology, University of Vienna, Austria
,
Felix Stockenhuber
The Department of Medicine I, Division of Haematology and Blood Coagulation and Division of Nephrology, University of Vienna, Austria
,
Brigitte Brenner
The Department of Medicine I, Division of Haematology and Blood Coagulation and Division of Nephrology, University of Vienna, Austria
,
Heinz Gössinger
The Department of Medicine I, Division of Haematology and Blood Coagulation and Division of Nephrology, University of Vienna, Austria
,
Christian Korninger
The Department of Medicine I, Division of Haematology and Blood Coagulation and Division of Nephrology, University of Vienna, Austria
,
Ingrid Pabinger
The Department of Medicine I, Division of Haematology and Blood Coagulation and Division of Nephrology, University of Vienna, Austria
,
Gere Sunder-Plassmann
The Department of Medicine I, Division of Haematology and Blood Coagulation and Division of Nephrology, University of Vienna, Austria
,
Peter Balcke
The Department of Medicine I, Division of Haematology and Blood Coagulation and Division of Nephrology, University of Vienna, Austria
,
Klaus Lechner
The Department of Medicine I, Division of Haematology and Blood Coagulation and Division of Nephrology, University of Vienna, Austria
› Author Affiliations
Further Information

Publication History

Received 26 February 1988

Accepted after revision 18 May 1988

Publication Date:
28 June 2018 (online)

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Summary

The formation of prostacyclin (PGI2) and thromboxane A2 and the release of beta-thromboglobulin (beta-TG) at the site of platelet-vessel wall interaction, i.e. in blood emerging from a standardized injury of the micro vasculature made to determine bleeding time, was studied in patients with end-stage chronic renal failure undergoing regular haemodialysis and in normal subjects. In the uraemic patients, levels of 6-keto-prostaglandin F1α (6-keto-PGF1α) were 1.3-fold to 6.3-fold higher than the corresponding values in the control subjects indicating an increased PGI2 formation in chronic uraemia. Formation of thromboxane B2 (TxB2) at the site of plug formation in vivo and during whole blood clotting in vitro was similar in the uraemic subjects and in the normals excluding a major defect in platelet prostaglandin metabolism in chronic renal failure. Significantly smaller amounts of beta-TG were found in blood obtained from the site of vascular injury as well as after in vitro blood clotting in patients with chronic renal failure indicating an impairment of the a-granule release in chronic uraemia. We therefore conclude that the haemorrhagic diathesis commonly seen in patients with chronic renal failure is - at least partially - due to an acquired defect of the platelet a-granule release and an increased generation of PGI2 in the micro vasculature.

Keywords

Bleeding time - Thromboxane - Prostacyclin - Beta-thromboglobulin - Chronic renal failure
 

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