Glucose Inhibits Prostacyclin Production by Cultured Aortic Endothelial Cells

Summary

A reduction in production of prostacyclin (PGI₂) by the cells in the vascular wall may play a role in the pathogenesis of atherosclerosis in diabetic patients. The present study was undertaken to evaluate the effect of glucose on PGI₂ production by endothelial cells in vitro. It was shown that PGI₂ production by cultured bovine aortic endothelial cells was significantly reduced in the presence of a high concentration of glucose (300 mg/dl) compared with physiological concentrations of glucose (100 mg/ dl). In contrast, no reduction in PGI₂ production was observed in cells cultured with equimolar mannitol, suggesting that glucose itself, rather than the effect of osmolality, inhibited PGI₂ production by cultured endothelial cells.

In addition, a high concentration of glucose also inhibited the proliferation of cultured endothelial cells.

Keywords

Glucose - Prostacyclin - Vascular endothelial cells Summary

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