Thromb Haemost 1988; 60(03): 495-497
DOI: 10.1055/s-0038-1646998
Original Article
Schattauer GmbH Stuttgart

Oxymetholone Therapy in Patients with Familial Antithrombin III Deficiency

Akira Shibuya
The Division of Hematology, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan
,
Haruhiko Ninomiya
The Division of Hematology, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan
,
Masaki Nakazawa
The Division of Hematology, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan
,
Toshiro Nagasawa
The Division of Hematology, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan
,
Yasuhiro Yoda
The Division of Hematology, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan
,
Tsukasa Abe
The Division of Hematology, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan
› Author Affiliations
Further Information

Publication History

Received 02 February 1988

Accepted after revision 09 August 1988

Publication Date:
30 June 2018 (online)

Summary

Three patients with familial antithrombin III (ATIII) deficiency, who also have histories of thromboembolism, were treated with oxymetholone in combination with warfarin. Thrombolysis was observed in one patient with acute thrombosis of inferior vena cava during the oxymetholone and warfarin therapy. No further thromboembolic episodes occurred in these patients after initiation of warfarin with or without oxymetholone. The levels of plasma ATIII, α1-antitrypsin, plasminogen and Cl-inactivator were significantly increased in all patients after the introduction of oxymetholone therapy. This suggests that oxymetholone augments anticoagulant and fibrinolytic activity. Hence we consider that oxymetholone in combination with warfarin may be possible thrombolytic therapy in patients with familial ATIII deficiency.

 
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