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Thromb Haemost 1989; 62(02): 752-755
DOI: 10.1055/s-0038-1646896
DOI: 10.1055/s-0038-1646896
Original Article
Stimulation of Plasmin Catalyzed Conversion of SingleChain to Two-Chain Urokinase-Type Plasminogen Activator by Sulfated Polysaccharides
Further Information
Publication History
Received 20 February 1989
Accepted after revision 03 March 1989
Publication Date:
30 June 2018 (online)
![](https://www.thieme-connect.de/media/10.1055-s-00035024/198902/lookinside/thumbnails/10-1055-s-0038-1646896-1.jpg)
Summary
Influence of heparin, chondroitin sulfate C and dextran sulfate (MW 3,500 and 7,000) on plasmin catalyzed conversion of singlechain (scu-PA) to two-chain (u-PA) urokinase-type plasminogen activator and generation of plasmin in mixtures of scu-PA and Glu-plasminogen (Glu-plg) was investigated. Conversion of scu-PA to u-PA catalyzed by plasmin was enhanced by chondroitin sulfate C and heparin, maximally by 10-fold and 3-fold, respectively. Sulfated polysaccharides potentiated generation of plasmin in mixtures of Glu-plg and scu-PA, as well as enhanced plasminogenolytic activity of u-PA. The possible role of these interactions is discussed.
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