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Thromb Haemost 1979; 41(04): 709-713
DOI: 10.1055/s-0038-1646830
Original Articles
Schattauer GmbH Stuttgart

Fibrinogen Zurich I: Impaired Release of Fibrinopeptide A

V Hofmann
The Thrombosis Laboratory, Department of Medicine, Inselspital, University of Berne, 3010 Berne and the Coagulation Laboratory, Department of Medicine, University of Zurich, Switzerland
,
W P Gati
The Thrombosis Laboratory, Department of Medicine, Inselspital, University of Berne, 3010 Berne and the Coagulation Laboratory, Department of Medicine, University of Zurich, Switzerland
,
P W Straub
The Thrombosis Laboratory, Department of Medicine, Inselspital, University of Berne, 3010 Berne and the Coagulation Laboratory, Department of Medicine, University of Zurich, Switzerland
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Publication History

Publication Date:
09 July 2018 (online)

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Summary

Fibrinogen Zurich I is characterized by an abnormal fibrin monomer polymerization. It consists of two fractions of molecules, one with a normal aggregation and one not aggregating at all and interfering with the aggregation of the normal population. Using a radioimmunoassay for fibrinopeptide A, only approximately half of the expected fibrinopeptide A could be recovered after thrombin or Defibrase proteolysis. The defective fibrinopeptide A release could be confirmed by measurement of the N-terminal Gly/Tyr ratio. It is likely that the abnormal fibrin monomer aggregation of the abnormal fraction of fibrinogen Zurich I is due to the defective fibrinopeptide A release of this fraction.

 

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