Thromb Haemost 1991; 66(04): 410-414
DOI: 10.1055/s-0038-1646429
Review Article
Schattauer GmbH Stuttgart

Are Haemostatic and Fibrinolytic Parameters Predictors of Preeclampsia in Pregnancy-Associated Hypertension?

C Caron
Laboratoire d'Hématologie et Département d'Anesthésie et de Réanimation de la Clinique Gynécologique et Obstétricale, France
,
J Goudemand
Laboratoire d'Hématologie et Département d'Anesthésie et de Réanimation de la Clinique Gynécologique et Obstétricale, France
,
A Marey
Laboratoire d'Hématologie et Département d'Anesthésie et de Réanimation de la Clinique Gynécologique et Obstétricale, France
,
D Beague
C.H.R.U. de Lille, France
,
G Ducroux
C.H.R.U. de Lille, France
,
F Drouvin
Laboratoire d'Hématologie et Département d'Anesthésie et de Réanimation de la Clinique Gynécologique et Obstétricale, France
› Author Affiliations
Further Information

Publication History

Received 30 March 1990

Accepted 03 April 1991

Publication Date:
25 July 2018 (online)

Summary

The plasma levels of several haemostatic and fibrinolytic parameters were measured before and after delivery in 61 hypertensive pregnant women of whom 22 developed preeclampsia, and compared to the results obtained in 42 normal pregnant women. In the two last weeks before delivery (D ≤ –15) tPA antigen, PAI-1 activity, vWF: Ag/FVIII: C ratio, ATIII activity and platelet count were found to be significantly different in the hypertensive pregnant women with and without preeclampsia. Combined all together, an association of three of these five parameters were found to be pathological (i.e.: tPA: Ag ≥19 ng/ml, PAI-1 activity ≥58 IU/ml, vWF: Ag/FVIII: C ratio 5≥2.6, ATIII activity ≤73%) in none of the hypertensive women without preeclampsia and in only 35% of the preeclamptic group. A positive correlation was demonstrated between vWF:Ag/FVIII:C ratio and tPA:antigen levels suggesting that both tPA and vWF: Ag could be considered as early indicators of a possible micro angiopathy occurring in preeclampsia. However, due to the high dispersion of the results, it appears that the investigated haemostatic and/or fibrinolytic criteria give only presumptive arguments before assigning risk for preeclampsia development among hypertensive pregnant women.