Download PDF
Thromb Haemost 1991; 66(03): 272-276
DOI: 10.1055/s-0038-1646406
Review Article
Schattauer GmbH Stuttgart

The Effect of Flow on Hemostasis and Thrombosis

Yale Nemerson
The Departments of Medicine and Biochemistry, the Mt. Sinai School of Medicine of the City University of New York, New York, N.Y.
,
Vincent T Turitto
*   The Department of Biomedical Engineering, Memphis State University, Memphis, TN, USA
› Author Affiliations
Further Information

Publication History

Received 21 January 1991

Accepted 28 March 1991

Publication Date:
25 July 2018 (online)

  PDF Download  Permissions and Reprints
 

  • References

  • 1 Goldsmith HL, Turitto VT. Rheological aspects of thrombosis and haemostasis: basic principles and applications. ICTH Report Subcommittee on Rheology of the International Committee on Thrombosis and Haemostasis. Thromb Haemostas 1986; 55: 415-35
    PubMedGoogle Scholar
  • 2 Laidler KJ, Bunting PS. The kinetics of immobilized enzyme systems. Methods Enzymol 1980; 64: 227-48
    PubMedGoogle Scholar
  • 3 Gemmell CH, Nemerson Y, Turitto V. The effects of shear rate on the enzymatic activity of the tissue factor-factor VIIa complex. Microvasc Res 1990; 40: 327-40
    CrossrefPubMedGoogle Scholar
  • 4 Gemmell CH, Turitto VT, Nemerson Y. Flow as a regulator of the activation of factor X by tissue factor. Blood 1988; 72: 1404-6
    PubMedGoogle Scholar
  • 5 Schoen P, Lindhout T, Willems G, Hemker HC. Continuous flow and the prothrombinase-catalyzed activation of prothrombin. Thromb Haemostas 1990; 64: 542-7
    PubMedGoogle Scholar
  • 6 Weiss HJ, Turitto VT, Baumgartner HR, Nemerson Y, Hoffmann T. Evidence for the presence of tissue factor activity on subendothelium. Blood 1989; 73: 968-75
    PubMedGoogle Scholar
  • 7 Moake JL, Turner NA, Stathopoulos NA, Nolasco LH, Heliums JD. Involvement of large plasma von Willebrand factor (vWF) multimers and unusually large vWF forms derived from endothelial cells in shear stress-induced platelet aggregation. J Clin Invest 1986; 78: 1456-61
    CrossrefPubMedGoogle Scholar
  • 8 Weiss HJ, Turitto VT, Baumgartner HR. Effect of shear rate on platelet interaction with subendothelium in citrated and native blood. I. Shear rate-dependent decrease of adhesion in von Willebrand's disease and the Bernard-Soulier syndrome. J Lab Clin Med 1978; 92: 750-64
    PubMedGoogle Scholar
  • 9 Moake JL, Turner NA, Stathopoulos NA, Nolasco LH, Heliums JD. Involvement of large plasma von Willebrand factor (vWF) multimers and unusually large vWF forms derived from endothelial cells in shear stress-induced platelet aggregation. J Clin Invest 1986; 78: 1456-61
    CrossrefPubMedGoogle Scholar
  • 10 Turitto VT, Weiss HJ, Baumgartner HR. Platelet interaction with rabbit subendothelium in von Willebrand's disease: altered thrombus formation distinct from defective platelet adhesion. J Clin Invest 1984; 74: 1730-41
    CrossrefPubMedGoogle Scholar
  • 11 Houdijk WP, de Groot PG, Nievelstein PF, Sakariassen KS, Sixma JJ. Subendothelial proteins and platelet adhesion. Von Willebrand factor and fibronectin, not thrombosponsin, are involved in platelet adhesion to extracellular matrix of human vascular endothelial cells. Arteriosclerosis 1986; 6: 24-33
    CrossrefPubMedGoogle Scholar
  • 12 Sixma JJ, Sakariassen KS, Beeser Visser NH, Ottenhof Rovers M, Bolhuis PA. Adhesion of platelets to human artery subendothelium: effect of factor VIII-von Willebrand factor of various multimeric composition. Blood 1984; 63: 128-39
    PubMedGoogle Scholar
  • 13 Weiss HJ, Turitto VT, Baumgartner HR. Platelet adhesion and thrombus formation on subendothelium in platelets deficient in glycoproteins IIb–IIIa, Ib, and storage granules. Blood 1986; 67: 322-30
    PubMedGoogle Scholar
  • 14 Sakariassen KS, Nievelstein PF, Coller BS, Sixma JJ. The role of platelet membrane glycopüroteins Ib and IIb–IIIa in platelet adherence to human artery subendothelium. Br J Haematol 1986; 63: 681-91
    CrossrefPubMedGoogle Scholar
  • 15 Turitto VT, Weiss HJ, Baumgartner HR. Decreased platelet adhesion on vessel segments in von Willebrand's disease: a defect in initial platelet attachment. J Lab Clin Med 1983; 102: 551-64
    PubMedGoogle Scholar
  • 16 de Groot PG, Sixma JJ. Role of von Willebrand factor in the vessel wall. Semin Thromb Hematol 1987; 13: 416
    PubMedGoogle Scholar
  • 17 Gralnick HR, Rick ME, McKeown LP. et al. Platelet von Willebrand factor: an important determinant of the bleeding time in type I von Willebrand's disease. Blood 1986; 68: 58-61
    PubMedGoogle Scholar
  • 18 Bowie EJ, Solberg Jr LA, Fass DN. et al. Transplantation of normal bone marrow into a pig with severe von Willibrand's disease. J Clin Invest 1986; 78: 26-30
    CrossrefPubMedGoogle Scholar
  • 19 Weiss HJ, Hawiger J, Ruggeri ZM, Turitto VT, Thiagarajan P, Hoffmann T. Fibrinogen-independent platelet adhesion and thrombus formation on subendothelium mediated by glycoprotein IIb–IIIa complex at high shear rate. J Clin Invest 1989; 83: 288-97
    CrossrefPubMedGoogle Scholar
  • 20 Weiss HJ, Turitto VT, Baumgartner HR. Role of shear rate and platelets in promoting fibrin formation on rabbit subendothelium. Studies utilizing patients with quantitative and qualitative platelet defects. J Clin Invest 1986; 78: 1072-82
    CrossrefPubMedGoogle Scholar
  • 21 Badimon L, Badimon JJ, Turitto VT, Fuster V. Role of von Willebrand factor in mediating platelet-vessel wall interaction at low shear rate; the importance of perfusion conditions. Blood 1989; 73: 961-7
    PubMedGoogle Scholar
  • 22 Folie BJ, McIntire LV. Mathematical analysis of mural thrombogenesis. Concentration profiles of platelet-activating agents and effects of viscous shear flow. Biophys J 1989; 56: 1121-41
    CrossrefPubMedGoogle Scholar
  • 23 Peterson DM, Stathopoulos NA, Giorgio TD, Heliums JD, Moake JL. Shear-induced platelet aggregation requires von Willebrand factor and platelet membrane glycoproteins Ib and IIb–IIIa. Blood 1987; 69: 625-8
    PubMedGoogle Scholar
  • 24 Levesque MJ, Nerem RM. The elongation and orientation of cultured endothelial cells in response to shear stress. J Biochem Eng 1985; 107: 341-7
    PubMedGoogle Scholar
  • 25 Olesen SP, Clapham DE, Davies PF. Haemodynamic shear stress activates a K+ current in vascular endothelial cells. Nature 1988; 331: 168-70
    CrossrefPubMedGoogle Scholar
  • 26 Diamond SL, Eskin SG, McIntire LV. Fluid flow stimulates tissue plasminogen activator secretion by cultured human endothelial cells. Science 1989; 243: 1483-5
    CrossrefPubMedGoogle Scholar
  • 27 Diamond SL, Sharefkin JB, Dieffenbach C, Frasier Scott K, McIntire LV, Eskin SG. Tissue plasminogen activator messenger RNA levels increase in cultured human endothelial cells exposed to laminar shear stress. J Cell Physiol 1990; 143: 364-71
    CrossrefPubMedGoogle Scholar
  • 28 Colucci M, Balconi G, Lorenzet R. et al. Cultured human endothelial cells generate tissue factor in response to endotoxin. J Clin Invest 1983; 71: 1893-6
    CrossrefPubMedGoogle Scholar
  • 29 Maynard JR, Dreyer BE, Stemerman MB, Pitlick FA. Tissue-factor coagulant activity of cultured human endothelial and smooth muscle cells and fibroblasts. Blood 1977; 50: 387-96
    PubMedGoogle Scholar
  • 30 Weiss HJ, Turitto VT, Vicic WJ, Baumgartner HR. Fibrin formation, fibrinopeptide A release, and platelet thrombus dimensions on subendothelium exposed to flowing native blood: greater in factor XII and XI than in factor VIII and IX deficiency. Blood 1984; 63: 1004-14
    PubMedGoogle Scholar
  • 31 Repke D, Gemmell CH, Guha A, Turitto VT, Broze Jr GJ, Nemerson Y. Hemophilia as a defect of the tissue factor pathway of blood coagulation: effect of factors VIII and IX on factor X activation in a continuous-flow reactor. Proc Natl Acad Sci USA 1990; 87: 7623-7
    CrossrefPubMedGoogle Scholar