Thromb Haemost 1991; 66(02): 254-258
DOI: 10.1055/s-0038-1646399
Review Article
Schattauer GmbH Stuttgart

Platelet 5-Hydroxytryptamine Increases with Platelet Age in Dogs

Diego Mezzano
The Department of Hematology-Oncology, School of Medicine, Catholic University, Santiago, Chile
,
Guido E del Pino
*   Department of Statistics, Faculty of Mathematics, Catholic University, Santiago, Chile
,
Marcelo Montesinos
The Department of Hematology-Oncology, School of Medicine, Catholic University, Santiago, Chile
,
M Eugenia García
The Department of Hematology-Oncology, School of Medicine, Catholic University, Santiago, Chile
,
Eduardo Aranda
The Department of Hematology-Oncology, School of Medicine, Catholic University, Santiago, Chile
,
Arnaldo Foradori
The Department of Hematology-Oncology, School of Medicine, Catholic University, Santiago, Chile
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Publikationsverlauf

Received 12. Juli 1990

Accepted 19. Februar 1991

Publikationsdatum:
25. Juli 2018 (online)

Summary

Thrombocytopenia was induced in mongrel dogs by two mechanisms: immunologically, by intravenous injection of heterologous antiplatelet antibody, and non-immunologically, by circulating the blood through glass beads in anesthetized animals. The platelet content of 5-HT was monitored before and during the recovery of the blood platelet counts. This period is associated with the normalization of the mean platelet survival time and with a progressive increase in the mean age of the circulating platelet population. A continuous increment in platelet 5-HT closely followed the increase in platelet counts in both models of thrombocytopenia, and a strong correlation was found between the platelet age and 5-HT content. These findings support the concept that platelets accumulate 5-HT during their physiological aging process, contradicting the notion that a negative balance in 5-HT content results at the end of their physiological lifespan in circulation. These results are not in conflict with the concept that circulating platelets release and re-uptake 5-HT.

 
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