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DOI: 10.1055/s-0038-1646399
Platelet 5-Hydroxytryptamine Increases with Platelet Age in Dogs
Publication History
Received 12 July 1990
Accepted 19 February 1991
Publication Date:
25 July 2018 (online)
![](https://www.thieme-connect.de/media/10.1055-s-00035024/199102/lookinside/thumbnails/10-1055-s-0038-1646399-1.jpg)
Summary
Thrombocytopenia was induced in mongrel dogs by two mechanisms: immunologically, by intravenous injection of heterologous antiplatelet antibody, and non-immunologically, by circulating the blood through glass beads in anesthetized animals. The platelet content of 5-HT was monitored before and during the recovery of the blood platelet counts. This period is associated with the normalization of the mean platelet survival time and with a progressive increase in the mean age of the circulating platelet population. A continuous increment in platelet 5-HT closely followed the increase in platelet counts in both models of thrombocytopenia, and a strong correlation was found between the platelet age and 5-HT content. These findings support the concept that platelets accumulate 5-HT during their physiological aging process, contradicting the notion that a negative balance in 5-HT content results at the end of their physiological lifespan in circulation. These results are not in conflict with the concept that circulating platelets release and re-uptake 5-HT.
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