Subscribe to RSS
DOI: 10.1055/s-0038-1646393
Variable Effects of Radiological Contrast Media on Thrombus Growth in a Rabbit Jugular Vein Thrombosis Model
Publication History
Received 24 July 1990
Accepted 19 February 1991
Publication Date:
25 July 2018 (online)
![](https://www.thieme-connect.de/media/10.1055-s-00035024/199102/lookinside/thumbnails/10-1055-s-0038-1646393-1.jpg)
Summary
We studied the effect of an ionic high osmolar contrast medium (Ioxitalamate), an ionic low osmolar contrast medium (Ioxaglate) and various nonionic low osmolar contrast media (Iopamidol, Iopromide and Iohexol) on thrombus growth in a rabbit jugular vein thrombosis model. Thrombus growth was determined by the accretion of 125I-labeled fibrinogen onto autologous preformed thrombi in rabbit jugular veins at various time-intervals from 15 min up to 10 h after infusion of the study solution.
The ionic low osmolar contrast medium markedly inhibited thrombus growth whereas all nonionic low osmolar contrast media promoted thrombus growth. The ionic high osmolar contrast medium inhibited thrombus growth, but less than the ionic low osmolar contrast medium. Within the group of nonionic contrast media, the Iopamidol associated promotion of thrombus growth was significantly higher than the Iopromide or Iohexol associated effects. The simultaneous administration of the apparently most potent thrombus growth promoting contrast medium (i.e. Iopamidol) and heparin resulted in complete abolishment of the increase in thrombus growth.
These results support the claims of prothrombotic properties of nonionic as compared to ionic contrast media and could explain the clinically encountered thromboembolic complications after the use of nonionic low osmolar contrast media.
-
References
- 1 Bettmann MA. Angiographic contrast agents: conventional and new media compared. AJR 1982; 139: 787-94
- 2 Gjolberg T, Andrew E, Enge I. Iohexol in phlebography of the leg. A comparative investigation with meglumine metrizoate. Invest Radiol 1985; 20: 103-6
- 3 Kinnison ML, Powe NR, Steinberg EP. Results of randomized controlled trials of low versus high osmolality contrast media. Radiology 1989; 170: 381-9
- 4 Laerum F, Holm HA. Postphlebographic thrombosis. Radiology 1981; 140: 651-4
- 5 Walters HL, Clemenson J, Browse NL, Lea Thomas M. 125I-Fibrinogen uptake following phlebography of the leg. Radiology 1980; 135: 619-21
- 6 Grollman JH, Kong Liu C, Astone RA, Lurie MD. Thromboembolic complications in coronary angiography associated with the use of nonionic contrast medium. Cath Cardiovasc Diagn 1988; 14: 159-64
- 7 Berge T, Bergqvist D, Efsing HO, Halbock T, Lindblad B, Lindhagen A. Complications of phlebography: a randomized comparison between ionic and nonionic contrast media. Clin Radiol 1989; 32: 595-8
- 8 Albrechtsson U, Olson CG. Thrombosis following phlebography with ionic and nonionic contrast media. Acta Radiol 1979; 20: 46-52
- 9 Minar E, Ehringer H, Sommer G, Marosi L, Czembirek H. Prevention of postvenographic thrombosis by heparin flush: fibrinogen uptake measurements. AJR 1984; 143: 629-32
- 10 Gasperetti CM, Feldman MD, Lawrence RB, Angello DA, Haugh KH, Owen RM, Powers ER. Nonionic contrast material is associated with thrombus formation during PTCA.. Circulation 1989; 80 (suppl) 375
- 11 Esplugas E. Risk of thrombosis during coronary angioplasty with lowosmolality contrast media: Comparative studies with Ioxaglate and Iohexol. Radiology 1990; 177: 279
- 12 Zir LM, Carvalho AC, Harthorne JW, Colman RW, Lees RS. Effect of contrast agents on platelet aggregation and 14C-serotonin release. N Engl J Med 1974; 291: 134-5
- 13 Belleville J, Baquet J, Paul J, Clendinnen G, Eloy R. In vitro study of the inhibition of coagulation induced by different radiocontrast molecules. Thromb Res 1985; 38: 149-62
- 14 Dawson P, Hewitt I, Mackie I, Machin SJ, Amin S, Bradshaw A. Contrast, coagulation and fibrinolysis. Invest Radiol 1986; 21: 248-52
- 15 Stormorken H, Skalpe IO, Testart MC. Effects of various contrast media on coagulation, fibrinolysis and platelet function. Invest Radiol 1986; 21: 348-54
- 16 Parvez Z, Moncada R, Fareed J, Messmore HL. Antiplatelet action of intravascular contrast media. Implications in diagnostic procedures. Invest Radiol 1984; 19: 208-11
- 17 Gafter U, Creter D, Zevin D. et al. Inhibition of platelet aggregation by contrast media. Radiology 1979; 132: 341-2
- 18 Ing JJ, Smith DC, Bull BS. Differing mechanisms of clotting inhibition by ionic and nonionic contrast agents. Radiology 1989; 172: 345-8
- 19 Fareed J, Walenga JM, Saravia GE, Moncada RM. Thrombogenic potential of nonionic contrast media?. Radiology 1990; 174: 321-5
- 20 Corot MS, Perrin JM, Belleville J, Amiel M, Eloy R. Effect of iodinated contrast media on blood clotting. Invest Radiol 1989; 24: 390-3
- 21 Kopko PM, Smith DC, Bull BS. Thrombin generation in nonclottable mixtures of blood and nonionic contrast agents. Radiology 1990; 174: 459-61
- 22 Hwang MH, En Piao Z, Murdock DK, Messmore HL, Giardina JJ, Scanlon PJ. Risk of thromboembolism during diagnostic and interventional cardiac procedures with nonionic contrast media. Radiology 1990; 174: 453-7
- 23 Grines CL, Diaz C, Mickelson J. Acute thrombosis in a canine model of arterial injury: effect of ionic versus nonionic contrast media. Circulation 1989; 80 (suppl) 11-411
- 24 Levi M, Pascucci C, Agnelli G, Sturk A, ten Cate JW. Effect on thrombus growth and thrombolysis of two types of low osmolar contrast media in a rabbit jugular vein thrombosis model. Invest Radiol 1990; 25: 533-5
- 25 Agnelli G, Pascucci C, Cosmi B, Nenci GG. The comparative effects of recombinant hirudin (CGP 39393) and standard heparin on thrombus growth in rabbits. Thromb Haemostas 1990; 63: 204-7