Download PDF
Thromb Haemost 1993; 70(01): 119-123
DOI: 10.1055/s-0038-1646171
State-of-the-Art Lecture
Flow
Schattauer GmbH Stuttgart

Mechanisms of Shear-induced Platelet Adhesion and Aggregation

Zaverio M Ruggeri
Roon Research Center for Arteriosclerosis and Thrombosis, Division of Experimental Hemostasis and Thrombosis, Department of Molecular and Experimental Medicine and Committee on Vascular Biology, The Scripps Research Institute, La Jolla, CA, USA
› Author Affiliations
Further Information

Publication History

Publication Date:
03 July 2018 (online)

Also available at
  PDF Download  Permissions and Reprints
 

  • References

  • 1 Peterson DM, Stathopoulos NA, Giorgio TD, Heliums JD, Moake JL. Shear-induced platelet aggregation requires von Willebrand factor and platelet membrane glycoproteins Ib and IIb-IIIa. Blood 1987; 69: 625-628
    PubMedGoogle Scholar
  • 2 Ikeda Y, Handa M, Kawano K, Kamata T, Murata M, Araki Y, Anbo H, Kawai Y, Watanabe K, Itagaki I, Sakai K, Ruggeri ZM. The role of von Willebrand factor and fibrinogen in platelet aggregation under varying shear stress. J Clin Invest 1991; 87: 1234-1240
    CrossrefPubMedGoogle Scholar
  • 3 Fowler WE, Fretto LJ, Hamilton KK, Erickson HP, McKee PA. Substructure of human von Willebrand factor. J Clin Invest 1985; 76: 1491-1500
    CrossrefPubMedGoogle Scholar
  • 4 Federici AB, Bader R, Pagani S, Colibretti ML, De Marco L, Man-nucci PM. Binding of von Willebrand factor (vWF) to glycoproteins (GP) Ib and IIb-IIIa complex: affinity is related to multimeric size. Br J Haematol 1989; 73: 93-99
    CrossrefPubMedGoogle Scholar
  • 5 Chow TW, Heliums JD, Moake JL, Kroll MH. Shear stress-induced von Willebrand factor binding to platelet glycoprotein Ib initiates calcium influx associated with aggregation. Blood. 1992; 80: 113-120
    PubMedGoogle Scholar
  • 6 Ikeda Y, Handa M, Kamata T, Kawano K, Kawai Y, Watanabe K, Sakai K, Mayumi F, Itagaki I, Yoshioka A, Ruggeri ZM. Transmembrane calcium influx associated with von Willebrand factor binding to GP Ib in the initiation of shear-induced platelet aggregation. Thromb Haemostas. 1993 in press
    PubMedGoogle Scholar
  • 7 Savage B, Shattil SJ, Ruggeri ZM. Modulation of platelet function through adhesion receptors: A dual role for glycoprotein IIb-IIIa (integrin αIIBβ3 mediated by fibrinogen and glycoprotein Ib-von Willebrand factor. J Biol Chem 1992; 267: 11300-11306
    PubMedGoogle Scholar
  • 8 Savage B, Ruggeri ZM. Selective recognition of adhesive sites in surface-bound fibrinogen by GP IIb-IIIa on nonactivated platelets. J Biol Chem 1991; 266: 11227-11233
    PubMedGoogle Scholar
  • 9 Weiss HJ, Turitto VT, Baumgartner HR. Effect of shear rate on platelet interaction with subendothelium in citrated and native blood. I. Shear rate-dependent decrease of adhesion in von Willebrand's disease and the Bernard-Soulier syndrome. J Lab Clin Med 1978; 92: 750-764
    PubMedGoogle Scholar
  • 10 Verstraete M, Vermylen J. Thrombosis. Pergamon Press; Elmsford, NY: 1984. pp. 49-51
    Google Scholar
  • 11 Sugimoto M, Ricca G, Hrinda ME, Schreiber AB, Searfoss GH, Bottini E, Ruggeri ZM. Functional modulation of the isolated glycoprotein lb-binding domain of von Willebrand factor expressed in Escherichia coli. Biochemistry 1991; 30: 5202-5209
    CrossrefPubMedGoogle Scholar
  • 12 Alevriadou RB, Moake JL, Turner NA, Ruggeri ZM, Folie BJ, Phillips MD, Schreiber AB, Hrinda ME, Mclntire LV. Real-time analysis of shear-dependent thrombus formation and its blockade by inhibitors of von Willebrand factor binding to platelets. Blood 1993; 81: 1263-1276
    PubMedGoogle Scholar