Download PDF
Thromb Haemost 1993; 70(01): 042-047
DOI: 10.1055/s-0038-1646157
Plenary Lecture
Schattauer GmbH Stuttgart

Human Fibrinogen—Structural Variants and Functional Sites

Agnes H Henschen
Department of Molecular Biology and Biochemistry, University of California at Irvine, Irvine, CA 92717, USA
› Author Affiliations
Further Information

Publication History

Publication Date:
03 July 2018 (online)

Also available at
  PDF Download  Permissions and Reprints
 

  • References

  • 1 Henschen A, McDonagh J. Fibrinogen, fibrin and factor XIII. In: Blood Coagulation. Zwaal RFA, Hemker HC. (eds) Elsevier; Amsterdam: 1986. pp. 171-241
    Google Scholar
  • 2 Lottspeich F, Henschen A. Amino acid sequence of human fibrin. Preliminary note on the completion of the γ-chain sequence. Hoppe-Seyler's Z Physiol Chem 1977; 358: 935-38
    PubMedGoogle Scholar
  • 3 Henschen A, Lottspeich F. Amino acid sequence of human fibrin. Preliminary note on the completion of the β-chain sequence. Hoppe-Seyler's Z Physiol Chem 1977; 358: 1643-46
    PubMedGoogle Scholar
  • 4 Henschen A, Lottspeich F, Hessel B. Amino acid sequence of human fibrin. Preliminary note on the completion of the intermediate part of the α-chain sequence. Hoppe-Seyler's Z Physiol Chem 1979; 360: 1951-56
    PubMedGoogle Scholar
  • 5 Doolittle RF, Watt KWK, Cottrell BA, Strong DD, Riley M. The amino acid sequence of the α-chain of human fibrinogen. Nature 1979; 280: 464-468
    CrossrefPubMedGoogle Scholar
  • 6 Chung DW, Harris JE, Davie EW. Nucleotide sequences of the three genes coding for human fibrinogen. In: Fibrinogen, Thrombosis, Coagulation and Fibrinolysis. Liu CY, Chien S. (eds). Plenum; New York: 1990. pp. 39-48
    Google Scholar
  • 7 Gårdlund B, Hessel B, Marguerie G, Murano G, Blombäck B. Primary structure of human fibrinogen. Characterization of disulfide-containing cyanogen-bromide fragments. Eur J Biochem 1977; 77: 595-610
    CrossrefPubMedGoogle Scholar
  • 8 Henschen A. Disulfide bridges in the middle part of human fibrinogen. Hoppe-Seyler's Z Physiol Chem 1978; 359: 1757-70
    PubMedGoogle Scholar
  • 9 Hoeprich PD, Doolittle RF. Dimeric half-molecules of human fibrinogen are joined through disulfide bonds in an antiparallel orientation. Biochemistry 1983; 22: 2049-55
    CrossrefPubMedGoogle Scholar
  • 10 Chung DW, Davie EW. γ and γ' chains of human fibrinogen are produced by alternative mRNA processing. Biochemistry 1984; 23: 4232-36
    CrossrefPubMedGoogle Scholar
  • 11 Fornace AJ, Cummings DE, Comeau CM, Kant JA, Crabtree GR. Structure of the human γ-fibrinogen gene. Alternate mRNA splicing near the 3' end of the gene produces γA and γB forms of γ-fibrinogen. J Biol Chem 1984; 259: 12826-30
    CrossrefPubMedGoogle Scholar
  • 12 Francis CW, Miiller E, Henschen A, Simpson PJ, Marder VJ. Car-boxyl-terminal amino acid sequences of two variant forms of the γ chain of human plasma fibrinogen. Proc Natl Acad Sci USA 1988; 85: 3358-62
    CrossrefPubMedGoogle Scholar
  • 13 Seydewitz HH, Witt I. Increased phosphorylation of human fibrino peptide A under acute phase conditions. Thromb Res 1985; 40: 29-39
    CrossrefPubMedGoogle Scholar
  • 14 Farrell DH, Mulvihill ER, Huang S, Chung DW, Davie EW. Recombinant human fibrinogen and sulfation of the γ' chain. Biochemistry 1991; 30: 9414-20
    CrossrefPubMedGoogle Scholar
  • 15 Henschen AH, Theodor I, Pirkle H. Hydroxyproline, a posttransla-tional modification of proline, is a constituent of human fibrinogen. Thromb Haemostas 1991; 65: 821
    PubMedGoogle Scholar
  • 16 Blombäck B, Gröndahl NJ, Hessel B, Iwanaga S, Wallèn P. Primary structure of human fibrinogen and fibrin. II. Structural studies on NH2-terminal part of γ chain. J Biol Chem 1973; 248: 5806-20
    PubMedGoogle Scholar
  • 17 Töpfer-Petersen E, Lottspeich F, Henschen A. Carbohydrate linkage site in the β-chain of human fibrin. Hoppe-Seyler's Z Physiol Chem 1976; 357: 1509-13
    PubMedGoogle Scholar
  • 18 Müller E, Henschen A. Isolation and characterization of human plasma fibrinogen molecular-size-variants by high-performance liquid chromatography and amino acid sequence analysis. In: Fibrinogen 3. Mosesson MW, Amrani DL, Siebenlist KR, Diorio JP. (eds). Excerp-ta Medica, Elsevier; Amsterdam: 1988. pp. 279-82
    Google Scholar
  • 19 Nakashima A, Sasaki S, Miyazaki K, Miyata T, Iwanaga S. Human fibrinogen heterogeneity: the COOH-terminal residues of defective Aα chains of fibrinogen II. Blood Coag Fibrinol 1992; 3: 361-70
    CrossrefPubMedGoogle Scholar
  • 20 Henschen A, Edman P. Large scale preparation of S-carboxymethy-lated chains of human fibrin and fibrinogen and the occurrence of γ-chain variants. Biochim Biophys Acta 1972; 263: 351-67
    CrossrefPubMedGoogle Scholar
  • 21 Henschen AH, Baumann R. Identification of polymorphic sites in the human fibrinogen chains using the polymerase chain reaction. Thromb Haemostas 1991; 65: 901
    PubMedGoogle Scholar
  • 22 Baumann RE, Henschen AH. Linkage disequilibrium between human fibrinogen DNA polymorphisms associated with the Bβ chain gene at the Hae III and Bβ448 sites. Thromb Haemostas. 1993 69. (abstr.)
    PubMedGoogle Scholar
  • 23 Baumann RE, Henschen AH. Genetic variation in human Bβ fibrinogen gene promoter influences formation of a specific DNA-pro-tein complex with the interleukin 6 response element. Thromb Haemostas. 1993 69. (abstr.)
    PubMedGoogle Scholar
  • 24 Humphries SE, Cook M, Dubowitz M, Stirling Y, Meade TW. Role of genetic variation at the fibrinogen locus in determination of plasma fibrinogen concentrations. Lancet 1987; 1452-55
    PubMedGoogle Scholar
  • 25 Ebert RF. Index of variant human fibrinogens. CRC Press, Boca Raton 1991; pp. 1-1-5-6
    PubMedGoogle Scholar
  • 26 Callea F, Tortora O, Kojima T, Lucini L, Brisigotti M, Fabbretti G, Favret M, Torchio B, Togni R, Albertini A, Henschen A. Hypofibrino-genemia and fibrinogen storage diseases. In: Fibrinogen 3. Mosesson MW, Amrani DL, Siebenlist KR, Diorio JP. (eds). Excerpta Medica, Elsevier; Amsterdam: 1988. pp. 247-50
    Google Scholar