Thromb Haemost 1995; 74(01): 309-312
DOI: 10.1055/s-0038-1642695
Plenary Lecture
Schattauer GmbH Stuttgart

Molecular Organization and Functional Regulation of Cell to Cell Junctions in the Endothelium

Elisbetta Dejana
Laboratoire de Hematologie, INSERM U217, Département de Biologie Molécuiaire et Structuraie CEN-G, Grenoble, France
,
Aldo Del Maschio
Istituto di Ricerche Farmacologiche Mario Negri, Vascular Biology Laboratory, Milano, Italy
› Author Affiliations
Further Information

Publication History

Publication Date:
09 July 2018 (online)

 
  • References

  • 1 Franke WW, Cowin P, Grand C, Kuhn C, Kepprell HP. The endothelial junction: the plaque and its components. In Endothelial Cell Biology in Health and Disease. Simionescu N, and Simionescu M. eds. New York: Plenum Press; 1988: 147-166
  • 2 Caveda L, Corada M, Martin-Padura I, Del Maschio A, Breviario F, Lampugnani MG, Dejana E. Structural characteristics and functional role of endothelial cell to cell junctions. Endothelium 1994; 2: 1-10
  • 3 Rubin LL. Endothelial cells: adhesion and tight junctions. Curr Opin Cell Biol 1992; 4: 830-833
  • 4 Simionescu N, Simionescu N. Endothelial transport macromolecules: transcytosis and endocytosis. Cell Biology Reviews 1991; 25: 5-80
  • 5 Gumbiner BM. Breaking through the tight junction barrier. J Cell Biol 1993; 123: 1631-1633
  • 6 Anderson JM, Baida MS, Fanning AS. The structure and regulation of tight junctions. Curr Opin Cell Biol 1993; 5: 772-778
  • 7 Risau W, Wolburg H. Development of the blood-brain barrier. Trends Neurosci 1990; 13: 174-178
  • 8 Beyer EC. Gap junctions. Int Rev Cytol 1993; 137 C l-37
  • 9 Furase M, Hi rase T, Itoh M, Nagafuchi A, Yonemura S, Tsukita S, and Tsukita S. Occludin: A novel integral membrane protein localizing at tight junctions. J Cell Biol 1993; 123: 1777-1788
  • 10 Hangxin L, Poznansky MJ. Characterization of the ZO-1 protein in endothelial and other cell lines. J Cell Sci 1990; 97: 231-237
  • 11 Zahraoui A, Joberty G, Arpin M, Fontaine JJ, Hellio R, Tavitian A, Louvard D. A small rab GTPase is distributed in cytoplasmic vesicles in non polarized cells but colocalizes with the tight junction maricer ZO-1 in polarized epithelial cells. J Cell Biol 1994; 124: 101-105
  • 12 Polacek D, Lai R, Volin MV, Davies PF. Gap junctional communication between vascular cells. Induction of connexin-43 messenger RNA in macrophage foam cells of atherosclerotic lesions Am J Pathol 1993; 112: 593-606
  • 13 Geiger B, Ayalon O. Cadherins. Ann Rev Cell Biol 1992; 8: 307-332
  • 14 Takeichi M. Cadherin cell adhesion receptors as a morphogenetic regulators. Science 1991; 251: 1451-1455
  • 15 Kemler R. From cadherins to catenins: cytoplasmic protein interactions and regulation of cell adhesion. TIG 1993; 9: 317-321
  • 16 Tsukita S, Tsukita S, Nagafuchi A, Yonemura S. Molecularlinkage between cadherins and act in filaments in cell-cell adherens junctions. Cur Opin Cell Biol 1992; 4: 834-839
  • 17 Granwald GB. The structural and functional analysis of cadherin calcium- dependent cell adhesion molecules. Cur Opin Cell Biol 1993; 5: 797-805
  • 18 Ranscht B. Cadherins and catenins: interactions and functions in embryonic development. Cur Opin Cell Biol 1994; 6: 740-756
  • 19 Salomon D, Ayalon O, Patel-King R, Hynes RO, Geiger B. Extrajunctional distribution of N-cadherin in cultured human endothelial cells. J Cell Sci 1992; 102: 1-11
  • 20 Lampugnani MG, Resnati M, Raiteri M, Pigott R, Pisacane A, Houen G, Ruco LP, Dejana E. A novel endothelial specific membrane protein is a marker of cell-cell contacts. J Cell Biol 1992; 118: 1511-1522
  • 21 Leach L, Clark P, Lampugnani MG, Arroyo AG, Dejana E, Firth JA. Imunoelectron characterization of the inter-endothelial junctions of human term placenta. J Cell Sci 1993; 104: 1073-1081
  • 22 Ayalon O, Sabanai H, Lampugnani MG, Dejana E, Geiger B. Spatial and temporal relationships between cadherins and PECAM-1 in cell-cell junctions of human endothelial cells. J Cell Biol 1994; 126: 247-258
  • 23 Suzuki S, Sano K, Tanihara H. Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue. Cell Regulation 1991; 2: 261-270
  • 24 Lampugnani MG, Corada M, Caveda L, Breviario F, Dejana E. The molecular organization of endothelial cell to cell junctions: differential association of plakoglobin β-catenin and a-catenin to vascular endothelial cadherin (VE-cadherin). J.Cell Biol in press.
  • 25 Meyer RA, Laird DW, Revel JP, Johnson RG. Inhibition of gap junction and adherens junction assembly by connexin and A.-CAM antibodies. J Cell Biol 1992; 119: 179-189
  • 26 DeLisser HM, Newman PJ, Albelda SM. Molecular and functional aspects of PECAM-1/CD31. Immunol Today 1994; 15: 490-495
  • 27 Lampugnani MG, Resnati M, Dejana E, Marchisio PC. The role of integrins in the maintenance of endothelial monolayer integrity. J Cell Biol 1991; 112: 479-490
  • 28 Esposito C, Gerlach H, Brett J, Stem D, Vlassara H. Endothelial receptor- mediated binding of glucose-modified albumin is associated with increase permeability and modulation of cell surface coagulant properties. J Exp Medicine 1989; 170: 1387-1407
  • 29 Hoschuetzky H, Aberle H, Kemler R. Beta-catenin mediates the interaction of the cadherin-catenin complex with epidermal growth factor receptor. J Cell Biol 1994; 127: 1375-1380
  • 30 Carlos TM, Harlan JM. Leukocyte-endothelial adhesion molecules. Blood 1994; 84: 2068-2101
  • 31 Springer TA. Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell 1994; 76: 301-314
  • 32 Luscinskas FW, Lawler J. Integrins as dynamic regulators of vascular function. FASEB J 1994; 8: 929-938
  • 33 Huang AJ, Silverstein SC. Mechanisms of neutrophil migration across endothelium. In Endothelial cell disfunction Simionescu N, and Simionescu M. eds. Plenum Press; New York: 1992: 201-231
  • 34 Huang AJ, Manning JE, Bandak TM, Ratau MC, Hanser KR, Silverstein SC. Endothelial cell cytosolic free calcium regulates neutrophil migration across monolayers of endothelial cells. J Cell Biol 1993; 120: 1371-1378
  • 35 Lauri D, Needham L, Dejana E. Tumor cell adhesion to the endothelium. In: Vascular endothelium interactions with circulating cells. Gordon J. ed Elsevier Science Publishers Amsterdam; 1991: 111-125