Thromb Haemost 1995; 74(01): 172-179
DOI: 10.1055/s-0038-1642672
Symposium
Molecular Basis of Fibrinolysis
Schattauer GmbH Stuttgart

The Enigma PAI-2. Gene Expression, Evolutionary and Functional Aspects

F Bachmann
Department of Medicine, Höpital Nestlé, University of Lausanne Medical Center, Lausanne, Switzerland
› Author Affiliations
Further Information

Publication History

Publication Date:
09 July 2018 (online)

 
  • References

  • 1 Kawano T, Morimoto K, Uemura Y. Urokinase inhibitor in human placenta. Nature 1968; 217: 253-254
  • 2 Kawano T, Morimoto K, Uemura Y. Partial purification and properties of urokinase inhibitor from human placenta. J Biochem 1970 67: 333-342
  • 3 Golder JP, Stephens RW. Minactivin: A human monocyte product which specifically inactivates urokinase-type plasminogen activators. Eur J Biochem 1983; 136: 517-522
  • 4 Vassalli JD, Dayer JM, Wohlwend A, Belin D. Concomitant secretion of prourokinase and of a plasminogen activator-specific inhibitor by cultured human monocytes-macrophages. J Exp Med 1984; 159: 1653-1668
  • 5 Kruithof EK O, Vassalli JD, Schleuning WD, Mattaliano RJ, Bachmann F. Purification and characterization of a plasminogen activator inhibitor from the histiocytic lymphoma cell line U-937. J Biol Chem 1986; 261: 11207-11213
  • 6 Schleuning WD, Medcalf RL, Hessian C, Rothenbühler R, Shaw MA, Kruithof EK O. Plasminogen activator inhibitor 2: regulation of gene transcription during phorbol ester-mediated differentiation of U-937 human histiocytic lymphoma cells. Mol Cell Biol 1987; 7: 4564-4567
  • 7 Webb AC, Collins KL, Snyder SE, Alexander SJ, Rosenwasser LJ, Eddy RL, Shows TB, Auron PE. Human monocyte Arg-Serpin cDNA. Sequence, chromosomal assignment, and homology to plasminogen activator-inhibitor. J Exp Med 1987; 166: 77-94
  • 8 Wun TC, Reich E. An inhibitor of plasminogen activation from human placenta. Purification and characterization. J Biol Chem 1987; 262: 3646-3653
  • 9 Antalis TM, Clark MA, Barnes T, Lehrbach PR, Devine PL, Schevzov G, Goss NH, Stephens RW, Tolstoshev P. Cloning and expression of a cDNA coding for a human monocyte-derived plasminogen activator inhibitor. Proc Natl Acad Sci USA 1988; 85: 985-989
  • 10 Kruithof EK O, Cousin E. Plasminogen activator inhibitor 2. Isolation and characterization of the promoter region of the gene Biochem Biophys Res Commun 1988; 156: 383-388
  • 11 Ye RD, Ahem SM, Le Beau MM, Lebo RV, Sadler JE. Structure of the gene for human plasminogen activator inhibitor-2. The nearest mammalian homologue of chicken ovalbumin. J Biol Chem 1989; 264: 5495-5502
  • 12 Sarnia JA, Alexander SJ, Horton KW, Auron PE, Byers MG, Shows TB, Webb AC. Chromosomal organization and localization of the human urokinase inhibitor gene: perfect structural conservation with ovalbumin. Genomics 1990; 6: 159-167
  • 13 Silverman GA, Jockel JI, Domer PH, Mohr RM, Taillon-MOler P, Korsmeyer SJ. Yeast artificial chromosome cloning of a two-megabase-size contig within chromosomal band 18q21 establishes physical linkage between BCL2 and plasminogen activator inhibitor type-2. Genomics 1991; 9: 219-228
  • 14 Ye RD, Wun T, Sadler JE. Mammalian protein secretion without signal peptide removal. Biosynthesis of plasminogen activator inhibitor-2 in U- 937 cells. J Biol Chem 1988; 263: 4869-4875
  • 15 von Heijne G, Liljestrom P, Mikus P, Andersson H, Ny T. The efficiency of the uncleaved secretion signal in the plasminogen activator inhibitor type 2 protein can be enhanced by point mutations that increase its hydrophobicity. J Biol Chem 1991; 266: 15240-15243
  • 16 Genton C, Kruithof EK O, Schleuning WD. Phorbol ester induces the biosynthesis of glycosylated and nonglycosylated plasminogen activator inhibitor 2 in high excess over urokinase-type plasminogen activator in human U-937 lymphoma cells. J Cell Biol 1987; 104: 705-712
  • 17 Wohlwend A, Belin D, Vassalli J. Plasminogen activator-specific inhibitors produced by human monocytes/macrophages. J Exp Med 1987; 165: 320-339
  • 18 Ye RD, Wun T, Sadler JE. cDNA cloning and expression in Escherichia coli of a plasminogen activator inhibitor from human placenta. J Biol Chem 1987; 262: 3718-3725
  • 19 Belin D, Wohlwend A, Schleuning WD, Kruithof EK O, Vassalli JD. Facultative polypeptide translocation allows a single mRNA to encode the secreted and cytosolic forms of plasminogen activators inhibitor 2. EMBO J 1989; 8: 3287-3294
  • 20 Jensen PH, Schuler E, Woodrow G, Richardson M, Goss N, Hojrap P, Petersen TE, Rasmussen LK. A unique inteihelical insertion in plasminogen activator inhibitor-2 contains three glutamines, Gln83 Gln84 Gln86essential for transglutaminase-mediated cross-linking. J Biol Chem 1994; 269: 15394-15398
  • 21 Radtke KP, Wenz KH, Heimburger N. Isolation of plasminogen activator inhibitor-2 (PAI-2) from human placenta. Evidence for vitronectin/PAI-2 complexes in human placenta extract Biol Chem Hoppe Seyler 1990; 371: 1119-1127
  • 22 Ny T, Hansson L, Lawrence D, Leonardsson G, Astedt B. Plasminogen activator inhibitor type 2 cDNA transfected into Chinese hamster ovary cells is stably expressed but not secreted. Fibrinolysis 1989; 3: 189-196
  • 23 Mikus P, Urano T, Liljestrom P, Ny T. Plasminogen-activator inhibitor type 2 (PAI-2) is a spontaneously polymerising SERPIN. Biochemical characterisation of the recombinant intracellular and extracellular forms EurJ Biochem 1993; 218: 1071-1082
  • 24 van den Berg EA, le Clercq E, Kooistra T, Frants RR, Bakker E. The human gene for plasminogen activator inhibitor 2 (PAI2) exhibits an EcoRl RFLP. Nucleic Acids Res 1990; 18: 2837-2837
  • 25 Young J, Antalis TM, Chenevix-Trench G. Bell RFLP of the plasminogen activator inhibitor type 2 gene (PLANH) on chromosome 18q21-q23. Nucleic Acids Res 1990; 18: 7196-7196
  • 26 Kiso U, Kaudewitz H, Henschen A, Astedt B, Kruithof EK O, Bachmann F. Deteimination of intermediates, products and cleavage site in the reaction between plasminogen activator inhibitor type-2 and urokinases. FEBS Lett 1988; 230: 51-56
  • 27 Lomas DA, Evans DL, Finch JT, Carrell RW. The mechnism of Z oq-antitrypsin accumulation in the liver. Nature 1992; 357: 605-607
  • 28 Miura Y, Kawabata SI, Iwanaga S. A limulus intracellular coagulation inhibitor with characteristics of the serpin superfamily. Purification, characterization, and cDNA cloning. J Biol Chem 1994; 269: 542-547
  • 29 Stein PE, Leslie AG, Finch JT, Carrell RW. Crystal structure of uncleaved ovalbumin at 1.95 A resolution. J Mol Biol 1991; 221: 941-946
  • 30 Pytel BA, Peppel K, Baglioni C. Plasminogen activator inhibitor type-2 is a major protein induced in human fibroblasts and SK-MEL-109 melanoma cells by tumor necrosis factor. J Cell Physiol 1990; 144: 416-422
  • 31 Hunt LT, Dayhoff MO. A surprising new protein superfamily containing ovalbumin, antithrombin-III, and alphaj-proteinase inhibitor. Biochem Biophys Res Commun 1980; 95: 864-871
  • 32 McReynolds L, O’Malley BW, Nisbet AD, Fothergill JE, Givol D, Fields S, Robertson M, Brownlee GG. Sequence of chicken ovalbumin mRNA. Nature 1978; 273: 723-728
  • 33 Heilig R, Muraskowsky R, Kloepfer C, Mandel JL. The ovalbumin gene family: complete sequences and structure of the Y gene. Nucleic Acids Res 1982; 10: 4363-4382
  • 34 Coughlin P, Sun J, Cerruti L, Salem HH, Bird P. Cloning and molecular characterization of a human intracellular serine proteinase inhibitor. Proc Natl Acad Sci USA 1993; 90: 9417-9421
  • 35 Suminami Y, Kishi F, Sekiguchi K, Kato H. Squamous cell carcinoma antigen is a new member of the serine protease inhibitors. J Mol Biol 1991; 221: 941-946
  • 36 Remold-O’Donnell E, Chin J, Alberts M. Sequence and molecular characterization of human monocyte/neutrophil elastase inhibitor. Proc Natl Acad Sci USA 1992; 89: 5635-5639
  • 37 Dubin A, Travis J, Enghild JJ, Potempa J. Equine leucocyte elastase inhibitor. Primary structure and identification as a thymosin-binding protein. J Biol Chem 1992; 267: 6576-6581
  • 38 Remold-O’Donnell E. The ovalbumin family of serpin proteins. FEBS Lett 1993; 315: 105-108
  • 39 Medcalf RL, Van den Berg E, Schleuning WD. Glucocorticoid-modulated gene expression of tissue- and urinary- type plasminogen activator and plasminogen activator inhibitor 1 and 2. J Cell Biol 1988; 106: 971-978
  • 40 Medcalf RL, Kruithof EK O, Schleuning WD. Plasminogen activator inhibitor 1 and 2 are tumor necrosis factor/cachectin-responsive genes. J Exp Med 1988; 168: 751-759
  • 41 Antalis TM, Godbolt D, Donnan KD, Stringer BW. Southwestern blot mapping of potential regulatory proteins binding to the DNA encoding plasminogen activator inhibitor type 2. Gene 1993; 134: 201-208
  • 42 Schuster WA, Medcalf RL, Kruithof EK O. Retinoic acid potentiates phorbol ester-mediated induction of urokinase and plasminogen activator inhibitortype 2 in human myeloid leukemic celllines. Endocrinology 1993; 133: 1724-1730
  • 43 Schuster WA, Medcalf RL, Kruithof EK O. Localization and characterization of a retinoic acid response-like element in the plasminogen activator inhibitor-2 gene promoter. Fibrinolysis 1994; 8: 113-119
  • 44 Nebert DW, Jones JE. Regulation of the mammalian cytochrome P1450 (CYP1A1) gene. Int J Biochem 1989; 21: 243-252
  • 45 Sutter TR, Guzman K, Dold KM, Greenlee WF. Targets for dioxin: genes for plasminogen activator inhibitor-2 and interleukin-lb. Science 1991; 254: 415-418
  • 46 Gaido KW, Maness SC. Regulation of gene expression and acceleration of differentiation in human keratinocytes by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Appl Phaimacol 1994; 127: 199-208
  • 47 Cousin E, Medcalf RL, Bergonzelli GE, Kruithof EK O. Regulatory elements involved in constitutive and phorbol ester inducible expression of the plasminogen activator inhibitor type 2 gene promoter. Nucleic Acids Res 1991; 19: 3881-3886
  • 48 Angel P, Imagawa M, Chiu R, Stein B, Imbra R, Rahmsdorf Hi, Jonat C, Herrlich P, Karin M. Phorbol ester-inducible genes contain a common c is element recognized by a TPA-modulator trans-acting factor. Cell 1987; 49: 729-739
  • 49 Medcalf RL. Cell-and gene-specific interactions between signal transduction pathways revealed by okadaic acid. Studies on the plasminogen activating system. J Biol Chem 1992; 267: 12220-12226
  • 50 Kumar S, Baglioni C. Protection from tumor necrosis factor-mediated cytolysis by overexpression of plasminogen activator inhibitor type-2. J Biol Chem 1991; 266: 20960-20964
  • 51 Hogquist KA, Nett MA, Unanue ER, Chaplin DD. Interleukin 1 is processed and release during apoptosis. Proc Natl Acad Sci USA 1991; 88: 8485-8489
  • 52 Jensen PH, Cressey LI, Gjertsen BT, Madsen P, Mellgren G, Hokland P, Gliemann J, Døskeland SO, Lanotte M, Vinteimyr OK. Cleaved intracellular plasminogen activator inhibitor 2 in human myeloleukaemia cells is a marker of apoptosis. Br J Cancer 1994; 70: 834-840
  • 53 Danesch U, Gloss B, Schmid W, Schutz G, Schule R, Renkawitz R. Glucocorticoid induction of the rat tryptophan oxygenase gene is mediated by two widely separated glucocorticoid response elements. EMBO J 1987; 6: 625-630
  • 54 de The H, Vicanco-Ruiz MM, Tiollais P, Stunnenberg H, Dejean A. Identifcation of a retinoic acid responsive element in the retinoic acid receptor beta gene. Nature 1990; 343: 177-180
  • 55 Huber R, Carrell RW. Implications of the three-dimensional structure of al-antitrypsin for structure and function of serpins. Biochemistry 1989; 28: 8951-8966