Thrombin Generation in Plasma: Its Assessment Via the Endogenous Thrombin Potential

• References

• 1 Hemker HC. Thrombin Generation, an Essential Step in Haemostasis and Thrombosis. In: “Haemostasis and Thrombose”. Bloom A. ed. et al. Churchill Livingstone Edinburgh: 1993: 477-490
• 2 Hemker HC, Wielders S, Kessels H, Beguin S. Continuous Registration of Thrombin Generation in Plasma, Its Use for the Determination of the Thrombin Potential. Thromb Haemost 1993; 70: 617-624
• 3 Nemerson Y. The tissue factor pathway of blood coagulation. Semin Haematol 1992; 29: 170-176
• 4 Furie B, Furie BC. Molecular and cellular biology of blood coagulation. N Eng J Med 1992; 326: 800-806
• 5 Mann KG. The coagulation explosion. Ann N Y Acad Sd 1994; 714: 265-269
• 6 Rapaport SI. The extrinsic pathway inhibitor: a regulator of tissue factor dependent blood coagulation. Thromb Haemost 1991; 66: 6-15
• 7 Walker FJ, Fay PJ. Regulation of blood coagulation by the protein C system. Faseb J 1992; 6: 2561-2567
• 8 Esmon CT. The roles of protein C and thrombomodulin in the regulation of blood coagulation. J Biol Chem 1989; 264: 4743-4746
• 9 Tans G, Nicolaes GA F, Thomassen MC L G D, Hemker HC, van Zonneveld A-J, Pannekoek H, Rosing J. Activation of human factor V by Meizothrombin. J Biol Chem 1994; 269: 15969-15972
• 10 Schoen P, Lindhout T. The in situ inhibition of prothrombinase-formed human a-thrombin and meizothrombin (des FI) by antithrombin III and heparin. J Biol Chem 1987; 262: 11268-11274
• 11 Schroit AJ, Zwaal RF A. Transbilayer Movement of Phospholipids in Red Cell and Platelet Membranes. Biochim Biophys Acta 1991; 1071: 313-329
• 12 Sixma JJ, De Groot PG. Regulation of platelet adhesion to the vessel wall. Ann N Y Acad Sci 1994; 714: 190-194
• 13 Giesen PL A, Willems GM, Hermens WT h. Production of thrombin by the prothrombinase complex is regulated by membrane-mediated transport of prothrombin. J Biol Chem 1991; 266: 1379-1382
• 14 Sel’kov EE. Nonlinearity of multi-enzyme systems. In: Analysis and simulation of biochemical systems. H C Hemker and B Hess edts. North-Holland/ American Elsevier 1972: 145-161
• 15 Biggs R, Macfarlane RG. Human blood coagulation and its disorders. Blackwell Scientific Publications. Oxford 1967
• 16 Bendetowicz AV, Beguin S, Caplain H, Hemker HC. Pharmacokinetics and Pharmacodynamics of a Low Molecular Weight Heparin (Enoxaparin) after Subcutaneous Injection, Comparison with Unfractionated Heparin. A Three Way Cross Over Study in Human Volunteers Thromb Haemost 1994; 71: 305-313
• 17 Bendetowicz AV, Kai H, Knebel R, Caplain H, Hemker HC, Lindhout T, Beguin S. The Effect of Subcutaneous Injection of Unfractionated and Low Molecular Weight Heparin on Thrombin Generation in Platelet Rich Plasma, A Study in Human Volunteers. Thromb Haemost 1994; 71: 305-313
• 18 Xi M, Beguin S, Hemker HC. The relative importance of factors II, VII, IX and X for the prothrombinase activity in plasma of orally anticoagulated patients. Thromb Haemost 1989; 62: 788-791
• 19 Knebel RW C, Vitoux D, Fiessinger JN, Aiach M, Beguin S, Hemker HC. The endogenous thrombin potential (ETP), preliminary data omits application during change of anticoagulant medication. Haemostasis, accepted for publication
• 20 Kessels H, Beguin S, Andree H, Hemker HC. Measurement of Thrombin Generation in Whole Blood. The Effect of Heparin and Aspirin Thromb Haemost 1994; 72: 78-83
• 21 Rotteveel RC, Roozendaal KJ, Eijsman L, Hemker HC. The Influence of Oral Contraceptives cm the Time-Integral of Thrombin Generation (Thrombin Potential). Thromb Haemost 1993; 70: 959-962
• 22 Duchemin J, Pittet J-L, Tartary M, Beguin S, Gaussem P, Alenc-Gelas M, Aiach M. A new essay based on thrombin generation inhibition to detect both protein C and protein S deficiencies in plasma. Thromb Haemst 1994; 71: 331-338