Darstellung von Metastasen eines Schilddrüsenkarzinoms mittels ¹¹¹In-Pentetreotide-Szintigraphie

Zusammenfassung

Zur Darstellung von Schilddrüsenkarzinomgewebe mittels Somatostatin-Rezep-torszintigraphie liegen bisher wenig Erfahrungen vor. Wir stellen die Kasuistik einer akromegalen Patientin vor, bei der die ¹¹¹ In-Pentetreotide-Szintigraphie -außer einem Somatostatinrezeptor-positiven Hypophysentumor - auch Metastasen eines papillären Schilddrüsenkarzinoms darstellte, die im unter Hypothyreose angefertigten Radiojodszintigramm kein Korrelat fanden. Der mögliche Stellenwert dieses Radiopharmazeutikums bei entdifferenzierenden Schilddrüsenkarzinomen wird in bezug auf den lokalisationsdiagnostischen Nutzen sowie auf die prädiktive Aussagekraft hinsichtlich des Erfolges einer Octreotide-Langzeit-behandlung diskutiert.

Summary

There is little experience with imaging of thyroid carcinoma tissue by somatostatin receptor scintigraphy. Our case report describes an acromegalic patient, in whom ¹¹¹ In pentetreotide scintigraphy did not only demonstrate a receptor-positive pituitary tumor but also visualized metastases from a papillary thyroid carcinoma which had no correlate in radioiodine scintigraphy carried out under hypothyroid conditions. The possible role of this radiopharmaceutical in dedifferentiating thyroid carcinoma is discussed for its usefulness in tumor localisation and its predictive value for the outcome of an octreotide therapy.

Schlüsselwörter

Schilddrüsenkarzinom - Hypophysentumor - Akromegalie - Szintigraphie - ¹¹¹In-Pentetreotide - Octreotide

Key words

Thyroid carcinoma - pituitary tumor - acromegaly - scintigraphy - ¹¹¹In-Pentetreotide - Octreotide

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