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DOI: 10.1055/s-0038-1629615
Kortikale Dysplasie als epileptogener Fokus: Verminderte Bindung von I-Iomazenil bei unauffälliger 99mTc-HMPAO SPECT
Cortical Dysplasia as an Epileptogenic Focus: Reduced Binding of 123I-Iomazenil with Normal Uptake in 99mTc-HMPAO SPECTPublikationsverlauf
Eingegangen:
03. März 1992
31. März 1992
Publikationsdatum:
04. Februar 2018 (online)
![](https://www.thieme-connect.de/media/10.1055-s-00034924/199204/lookinside/thumbnails/10-1055-s-0038-1629615_de-1.jpg)
Zusammenfassung
In kortikalen Arealen, die einem epileptischen Fokus assoziiert sind, korreliert meist eine verminderte Benzodiazepin-Rezeptorbindung, darstellbar mit 123I- Iomazeml, mit einer Minderung des regionalen zerebralen Blutflusses. Anhand eines Fallbeispiels mit ausgeprägter Minderung der 123l-lomazenilbindung im epileptischen Fokus bei ungestörtem regionalen zerebralen Blutfluß wird illustriert und diskutiert, daß bei einer Minderanreicherung von 123I-Iomazenil im epileptischen Fokus eine Alteration des GABAergen Systems anzunehmen ist.
Summary
In cortical areas associated with an epileptic focus, there is, in the majority of cases, a correlation between decreased benzodiazepine (Bz) receptor binding, detectable with 123I-Iomazeml, and decreased blood flow. A patient with focal epilepsy due to a localized abnormality in cortical differentiation is presented who showed a marked focal decrease in Bz receptor binding and a normal 99mTc-HMPAO SPECT. Based on this case the relation between blood flow and Bz receptor binding in epileptic foci is discussed.
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