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DOI: 10.1055/s-0038-1628874
Myokardszintigraphie mit kationischen 99mTc-Komplexen[*]
Myocardial Scintigraphy with Kationic 99mTc ComplexesPublication History
Eingegangen:
25 March 1987
Publication Date:
04 February 2018 (online)
![](https://www.thieme-connect.de/media/10.1055-s-00034924/198703/lookinside/thumbnails/10-1055-s-0038-1628874_de-1.jpg)
This report summarizes the results which have been achieved by the use of 99mTc-labeled cationic complexes for myocardial scintigraphy. Radiopharma-cological aspects of 99mTc(lll)-CI2 (D.MPE)2 and 99mTc(l)-TBI as well as their scintigraphic behaviour in patients with coronary artery disease are described. In contrast to 99mTc-CI2 (DMPE)2, 99mTc-TBI could be used successfully for the assessment of ischemic and infarcted myocardial tissue. Yet in general, 201TI scintigraphic findings remained superior. However, from the considerable improvements achieved it is likely that soon a 99mTc-labeled tracer will be available to serve as clinical useful myocardial imaging agent
Zusammenfassung
Der vorliegende Bericht beschreibt die bisherigen Erfahrungen bei der Anwendung von kationischen 99mTc-Komplexen zur Myokardszintigraphie. Insbesondere werden radiopharmakologische Aspekte und szintigra-phische Ergebnisse von 99mTc(III)-C12(DMPE)2 und 99mTc(I)-TBI besprochen. Im Gegensatz zu 99mTc-CL2(DMPE)2 fanden sich mit 99mTc-TBI mehrheitlich verwertbare szintigraphische Befunde. 99mTc-TBI ermöglichte den Nachweis von infarkt-und nichtinfarktbezogenen Koronargefäßstenosen. Es bestanden jedoch im Vergleich zu 201T1 verschiedene Nachteile. Die erzielten Fortschritte lassen jedoch vermuten, daß in Kürze ein für die Myokardszintigraphie geeigneter 99mTc-markierter Tracer zur Verfügung stehen wird.
* Vortrag gehalten anläßlich der 2. Wissenschaftlichen Tagung der Deutschen Gesellschaft für Nuklearmedizin in Freiburg im Breisgau, 2.-4. April 1987.
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Literatur
- 1 Angelberger P, Wagner-Löffler M, Hruby E, Dudczak R. Synthesis, radiochromatography and biodistribution of 99mTc-Dimethylphosphinoethane (DMPE) complexes. J. radioanalyt. nucl. Chem 1985; 89: 409-21.
- 2 Angelberger P, Dudczak R, Jones A. G. et al. Optimized radiochemistry and clinical evaluation of 99mTc-hexakis-(t-butyli-sonitrile)-technetium(I) cation (99mTc-TBI): A potential myocardial perfusion tracer. In: Radioaktive Isotope in Klinik und Forschung. Höfer R, Bergmann H. Hrsg. 51-8 Egermann, Wien: 1986
- 3 Angelberger P, Dudczak R, Jones A. G. et al. 99mTc-hexakis (t-butylisonitrile)-technetium(I) (99mTc-TBI): Optimized synthesis, radiochromatography, biodistribution and preliminary clinical studies. In: Technetium in Chemistry and Nuclear Medicine. Nicolini M, Bandoli G, Mazzi U. eds. 177-86 Raven Press, New York: 1986
- 4 Angelberger P, Dudczak R. In vivo behaviour of radiopharmaceuticals for myocardial imaging and metabolic studies. In: Progress in Radiopharmacy. Cox P. H, Mather S. J, Sampson C. B, Lazarus C. R. eds. 434-62 Martinus Nijhoff, Dordrecht -Boston -Lancaster: 1986
- 5 Campbell S, Holman B. L, Kirshenbaum J. M. et al. The scintigraphic evaluation of myocardial infarction and regional ventricular performance using 99mtechnetium hexakis (t-butylisonitrile) technetium(I) (TBI): A new myocardial imaging agent. Eur. J. nucl. Med 1986; 12: 219-24.
- 6 Deutsch E, Glavan K. A, Sodd V. J. et al. Cationic 99mTc complexes as potential myocardial imaging agents. J. nucl. Med 1981; 22: 897-907.
- 7 Deutsch E, Bushong W, Glavan K. A. et al. Heart imaging with cationic complexes of technetium. Science 1981; 214: 85-6.
- 8 Dudczak R, Angelberger P, Homan R. et al. Evaluation of 99mTc-dichloro bis (1,2-dimethylphosphino)-ethane (99mTc-DMPE) for myocardial scintigraphy in man. Eur. J. nucl. Med 1983; 08: 513-5.
- 9 Eakins M. N, Glavan K. A, Kronauge J. F. et al. The myocardial uptake and biodistribution of kit formulated, 99mTc-labeled cationic complex, . Tc(dmpe)2Cl2 + . J. Lab. Comp. Radio-pharmaceut 1982; 19: 1457-9.
- 10 Gerson M. C, Deutsch E. A, Nishi-yama H. et al. Myocardial perfusion imaging with 99mTc-DMPE in man. Eur. J. nucl. Med 1983; 08: 371-4.
- 11 Holman B. L, Jones A. G, Lister-James J. et al. A new 99mTc-labeled myocardial imaging agent, hexakis (t-butylisoni-trile)-technetium(I) (99mTc-TBI): Initial experience in the human. J. nucl. Med 1984; 25: 1350-5.
- 12 Holman B. L, Campbell C, Lister-James J. et al. Effect of reperfusion and hyperemia on the myocardial distribution of 99mtechnetium t-butylisonitrile. J. nucl. Med 1986; 27: 1172-7.
- 13 Holman B. L, Sporn V, Jones A. G. et al. Myocardial imaging with 99mtechnetium CPI: Initial experience in the human. J. nucl. Med 1987; 28: 13-8.
- 14 Jones A. G, Abrams M. J, Davison A. et al. Biological studies of a new class of technetium complexes: The hexakis (al-kyl-isonitrile) technetium(I) cations. Int. J. nucl. Med. Biol 1984; 11: 225-34.
- 15 Khalil M. N, Thornback J, Early M. Y. et al. ““Technetium isonitrile complex as a potential myocardial imaging agent. Nucl. Med. Commun 1985; 06: 615-22.
- 16 Nishiyama H, Deutsch E, Adolph R. J. et al. Basal kinetic studies of 99mTc-DMPE as a myocardial imaging agent in the dog. J. nucl. Med 1982; 23: 1093-101.
- 17 Nishiyama H, Adolph R. J, Deutsch E. et al. Effekt of coronary blood flow on uptake and washout of 99mTc-DMPE and 201T1. J. nucl. Med 1982; 23: 1102-10.
- 18 Schmoliner R. 201Thallium-Myokardszin-tigraphie nach Dipyridamol. Wertigkeit und Grenzen in der Diagnostik der koronaren Herzkrankheit. Facultas, Wien: 1985
- 19 Schiimichen C, Altenburger G, Bergmann P. 99mTc-DMPE, Ersatz für 201T1 in der Myokardszintigraphie?. Nucl.-Med 1984; 21 Suppl. (Suppl. 20) 116-9.
- 20 Sia S. T. B, Holman B. L, McKusick K. et al. The utilization of 99mTc-TBI as a myocardial perfusion agent in exercise studies: Comparison with 201T1 thallous chloride and examination of its biodistribution in humans. Eur. J. nucl. Med 1986; 12: 333-6.
- 21 Sullivan P. J, Werre J, Elmaleh D. R. et al. A comparison of the technetium labeled myocardial agents DiArs and DMPE to 201T1 in experimental animals. Int. J. nucl. Med. Biol 1984; 11: 3-10.
- 22 Vanderheyden J. L, Deutsch E, Libson K, Ketring A. R. Synthesis and characterization of 99mTc(dmpe) +, a potential myocardial imaging agent. J. nucl. Med 1983; 24: 9.
- 23 Vikydal R, Dudczak R, Schmoliner R. et al. Myocardial imaging with 99mTc-TBI at rest and after dipyridamol (DPM) stress. J. nucl. Med 1986; 27: 878.
- 24 Williams S. J, Mousa S. A, Morgan R. A, Carroll T. R, Maheu L. J. Pharmacology of 99mTc-isonitriles: Agents with favorable characteristics for heart imaging. J. nucl. Med 1986; 27: 877.