Skalen und Scores zur Erfassung nicht motorischer Symptome beim Morbus Parkinson

Zusammenfassung

Nicht motorische Symptome des idiopathischen Parkinson-Syndroms (IPS) werden im klinischen Alltag zu selten diagnostiziert und ungenügend therapiert. Mit dem Non-motor Symptoms Questionnaire (NMSQuest) und der Non-motor Symptoms Scale (NMSScale) stehen zwei Skalen zur Verfügung, mit denen ein Großteil der möglichen nicht motorischen Beschwerden erfasst werden können. Beim NMSQuest handelt es sich um eine kurze Screening-Liste zu nicht motorischen Symptomen, die im Wartezimmer von den Patienten ausgefüllt werden kann. Während der ärzt-lichen Konsultation kann der Untersucher gezielt auf die angekreuzten Symptome eingehen und diese mithilfe der NMSScale quantifizieren. Zur Evaluierung einzelner nicht motorischer Symptome stehen zusätzliche validierte Skalen zur Verfügung.

Summary

Non-motor symptoms in Parkinson’s disease (PD) are still often underdiagnosed and therefore not adequately treated. The Non-motor Symptoms Questionnaire (NMSQuest) und der Non-motor Symptoms Scale (NMSScale) are two scales which assess the majority of possible non-motor symptoms. The NMSQuest is a short screening tool for non-motor symptoms, that can be completed by the patients while they are waiting to be seen. During the clinic consultation those symptoms identified can be explored further and quantified using the NMSScale. There are additional scales available for the evaluation of individual non-motor symptoms.

Schlüsselwörter

Morbus Parkinson - nicht motorische Symptome - Fragebogen

Keywords

Parkinson’s disease - non-motor symptoms - questionnaire

• Literatur

• 1 Parkinson J. An essay on the shaking palsy. J Neuropsychiatry Clin Neurosci 2002; 14: 223-36.
• 2 Chaudhuri KR, Healy DG, Schapira AHV. Non-motor symptom of Parkinson’s disease: diagnosis and management. Lancet Neurol 2006; 5: 234-45.
• 3 Chaudhuri KR, Odin P, Antonini A, Martinez-Martin P. Parkinson’s disease: The non-motor issues. Parkinsonism Relat Disord 2011; 17: 717-23.
• 4 Hely MA, Morris JG, Reid WG, Trafficante R. Sydney multicenter study of Parkinson’s Disease: non-L-dopa-responsive problems dominate at 15 years. Mov Disord 2005; 20 (02) 190-9.
• 5 Martinez-Martin P, Rodriguez-Blazques C, Kurtis MM, Chaudhuri KR. The impact of non-motor symptoms on health-related quality of life of patients with Parkinson’s disease. Mov Disord 2011; 26 (03) 399-406.
• 6 Shulman LM, Taback RL, Rabinstein AA, Weiner WJ. Non-recognition of depression and non-motor symptoms in Parkinson’s disease. Parkinsonism Relat Disord 2002; 8: 193-7.
• 7 Storch A. et al. Non-motor symptoms questionnaire und Scale für das idiopathische Parkinson-Syndrom. Nervenarzt 2010; 81: 980-85.
• 8 Goetz CG. et al. Movement disorder society-sponsored revision of the Unified Parkinson’s Disease Rating Scale (MDS-UPDRS): scale presentation and clinimetric testing. Mov Disord 2008; 23 (15) 2129-70.
• 9 Gallagher DA, Goetz CG, Stebbins G, Lees AJ, Schrag A. Validation of the MDS-UPDRS Part I for nonmotor symptoms in Parkinson’s disease. Mov Disord 2012; 27 (01) 79-83.
• 10 Chaudhuri KR. et al. International multicenter pilot study of the first comprehensive self-completed nonmotor symptoms questionnaire for Parkinson’s disease: the NMSQuest study. Mov Disord 2006; 21 (07) 916-23.
• 11 Martinez-Martin P. et al. Prevalence of nonmotor symptoms in Parkinson’s disease in an international setting: study using nonmotor symptoms questionnaire in 545 patients. Mov Disord 2007; 22 (11) 1623-9.
• 12 Perez Lloret S, Rossi M, Cardinali DP, Merello M. Validation of the sleep related item of the Non-motor Symptoms Questionnaire for Parkinson’s disease (NMSQuest). Parkinsonism Relat Disord 2008; 14 (08) 641-5.
• 13 Chaudhuri KR, Martinez-Martin P. Quantitation of non-motor symptoms in Parkinson’s disease. Eur J Neurol 2008; 15 (02) 2-8.
• 14 Chaudhuri KR. et al. The metric properties of a novel non-motor symptoms scale for Parkinson’s disease: Results from an international PIlot Study. Mov Disord 2007; 22 (13) 1901-11.
• 15 Martinez-Martin P. et al. International study on the psychometric attributes of the non-motor symptoms scale in Parkinson disease. Neurology 2008; 73 (19) 1584-91.
• 16 Schneider CB. et al. Utility of the WHO-Five Well-being Index as a screening tool for depression in Parkinson’s disease. Mov Disord 2010; 25 (06) 777-83.
• 17 Schrag A. et al. Depression rating scales in Parkinson’s disease: Critique and recommendations. Mov Disord 2007; 22 (08) 1077-92.
• 18 Storch A. et al. Validity of the DESPAR questionnaire as a new screening tool for depression in Parkinson’s disease. Basal Ganglia 2011; 1: 97-103.
• 19 Marsh L, McDonald WM, Cummings J, Ravina B. Provisional diagnostic criteria for depression in Parkinson’s disease: report of an NINDS/NIMH Work Group. Mov Disord 2006; 21 (02) 148-58.
• 20 Lemke MR, Ceballos-Baumann AO. Depression bei Parkinon-Patienten. Dtsch Ärztebl 2002; 99 (40) 2625-31.
• 21 Aarsland D, Zaccai J, Brayne C. A systematic review of prevalence studies of dementia in Parkinson’s disease. Mov Disord 2005; 20: 1255-63.
• 22 Dalrymple-Alford JC. et al. The MoCA: well-suited screen for cognitive impairment in Parkinson’s disease. Neurology 2010; 75 (19) 1717-25.
• 23 Hoops S. et al. Validity of the MoCA and MMSE in the detection of MCI and dementia in Parkinson disease. Neurology 2009; 73 (21) 1738-45.
• 24 Kalbe E. et al. Screening for cognitive deficits in Parkinson’s disease with the Parkinson neuropsychometric dementia assessment (PANDA). Parkinsonism Relat Disord 2008; 14 (02) 93-101.
• 25 Leentjens AFG, Dujardin K, Marsh L, Richard IH, Starkstein S, Martinez-Martin P. Anxiety rating scales in Parkinson’s disease: A validation study of the Hamilton Anxiety Rating Scale, the Beck Anxiety Inventory, and the Hospital Anxiety and Depression Scale. Mov Disord 2011; 26 (03) 407-15.
• 26 Fenelon G, Mahieux F, Huon R, Ziegler M. Hallucinations in Parkinson’s disease: prevalence, phenomenology and risk factors. Brain 2000; 123: 733-45.
• 27 Fernandez HH. et al. Scales to assess psychosis in Parksinon’s disease: Critique and recommendations. Mov Disord 2008; 23 (04) 484-500.
• 28 Factor SA, McAlarney T, Sanchez-Ramos JR, Weiner WJ. Sleep disorders and sleep effect in Park-inson’s disease. Mov Disord 1990; 5: 280-85.
• 29 Lowe AD. Sleep in Parkinson’s disease. J Psychosom Res 1998; 44: 613-17.
• 30 Martinez-Martin P, Visser M, Rodriguez-Blazques C, Marinus J, Chaudhuri KR. SCOPA-Sleep and PDSS: Two scales for assessment of sleep disorder in Parkinson’s disease. Mov Disord 2008; 23 (12) 1681-88.
• 31 Chaudhuri KR. et al. The Parkinson’s disease sleep scale: a new instrument for assessing sleep and nocturnal disability in Parkinson’s disease. J Neurol Neurosurg Psychiatry 2002; 73: 629-35.
• 32 Högl B. et al. Scales to assess sleep impairment in Parkinson’s disease: Critique and recommendations. Mov Disord 2010; 25 (16) 2704-16.
• 33 Sullivan SS, Williams DR, Gallagher DA, Massey LA, Silveira-Moriyama L, Lees AJ. Nonmotor symptoms as presenting complaints in Parkinson’s disease: A clinicopathological study. Mov Disord 2008; 23 (01) 101-6.
• 34 Friedman JH. et al. Fatigue rating scales: Critique and recommendations by the movement disorders society task force in rating scales for Parkinson’s disease. Mov Disord 2010; 25 (07) 805-22.
• 35 Visser M, Marinus J, Stiggelbout AM, van Hilten JJ. Assessment of autonomic dysfunction in Parkinson’s disease: The SCOPA-AUT. Mov Disord 2004; 19 (11) 1306-12.
• 36 Evatt ML. et al. Dysautonomia rating scales in Park-inson’s disease: Sialorrhoea, dysphagia, and constipation – critique and recommendations by movement disorders task force on rationg scales for Park-inson’s disease. Mov Disord 2009; 24 (05) 635-46.
• 37 Pavy-Le Traon A. et al. The movement disorders task force review of dysautonomia rating scales in Parkinson’s disease with regard to symptoms of orthostatic hypotension. Mov Disord 2011; 26 (11) 1985-92.