Thorac Cardiovasc Surg 2018; 66(S 01): S1-S110
DOI: 10.1055/s-0038-1627905
Oral Presentations
Sunday, February 18, 2018
DGTHG: Aspects of Thoracic Surgery
Georg Thieme Verlag KG Stuttgart · New York

Predictive Risk Factors for Lymph Node Metastases in Patients with Resected Non-Small Lung Cancer: Single-center Experience

Y. Mulla
1   Department of Visceral, Transplant, Thoracic and Vascular Surgery, University Hospital Leipzig, Leipzig, Germany
,
S. Krämer
1   Department of Visceral, Transplant, Thoracic and Vascular Surgery, University Hospital Leipzig, Leipzig, Germany
,
T. Doenst
2   Klinik für Herz- und Thoraxchirurgie, Friedrich-Schiller-Universität Jena, Jena, Germany
,
M. Steinert
2   Klinik für Herz- und Thoraxchirurgie, Friedrich-Schiller-Universität Jena, Jena, Germany
,
U. Eichfeld
1   Department of Visceral, Transplant, Thoracic and Vascular Surgery, University Hospital Leipzig, Leipzig, Germany
› Author Affiliations
Further Information

Publication History

Publication Date:
22 January 2018 (online)

   All articles of this category

Introduction: The estimation of lymph node status in the patients with non-small lung cancer (NSCLC) is essential to determine the optimal therapy. However, the lymph node involvement is a very powerful prognostic factor. We aim through this study to detect the predictive factors for lymph node metastasis in the patients with resected NSCLC in our department of thoracic surgery university hospital Leipzig.

Materials and Methods: We retrospectively recorded all the patients with NSCLC, who underwent surgical resection and systematic lymph node dissection (SND) in our hospital. between 01/2007 and 12/2016. Correlation between clinicopathological parameter and lymph node metastasis were detected using univariate and binary logistic regression analysis.

Results: In this study were conducted 204 patients with resected NSCLCs, 142 men (71.7%) and 56 women (28.3%) (gender ratio, men to women = 2.5:1). Systematic node dissection (SND) was performed in all these patients. Lymph node metastasis was detected in 38.2% (78/204). Central tumor localization (OR = 2.62, 95%, CI = 1.3–5.1, p = 0.005) and tumor size (OR = 2.4, 95% CI = 1.3–4.6, p = 0.05) were preoperatively found as predictive significant factors for lymph node metastasis. Postoperatively, a multivariate analysis showed that intratumoral lymph invasion (L1-Status) strongly associated with lymph node metastasis (OR = 17.28, 95% CI = 5.2–58.4, p < 0.001). In addition, in small size tumors (< = 3cm) two predictive factors were found for lymph node metastasis: Central tumor localization (OR = 19.43, CI = 2.06–186.38, p = 0.01) and L1-Status (OR = 43.88, CI = 3.63–529.43,p = 0.003).

Conclusion: In the patients with large tumor size and central localization, a precise preoperatively and intraoperatively assessment of the lymph node status is essential. L1-Status is a highly significant risk factor for lymph node metastasis in surgical treated NSCLCs. Therefore, a postoperative evaluation of adjuvant therapy concepts for these patients is recommended.