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Nervenheilkunde 2008; 27(05): 381-389
DOI: 10.1055/s-0038-1627329
Original- und Übersichtsarbeiten - Original and Review Articles
Schattauer GmbH

Insulärer Kortex und Sprachproduktion

Insular cortex and speech production
A. Riecker
1   Neurologische Universitätsklinik, Universität Ulm
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Publication History

Eingegangen am: 10 July 2007

angenommen am: 19 July 2007

Publication Date:
20 January 2018 (online)

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Zusammenfassung

Klinische und funktionell-bildgebende Daten weisen darauf hin, dass die linke vordere Inselregion an prä-artikulatorischen Aspekten der Sprachproduktion wie der ,,Programmierung und Planung von Artikulationsbewegungen“ beteiligt ist. Um zwischen prä-artikulatorischen und artikulatorischen Störungen zu unterscheiden, wurde die Hirnaktivierung bei nichtlautierender und bei lautierender Sprachproduktion miteinander verglichen. Als Kontrollbedingung haben die Probanden sowohl lautierend als auch nichtlautierend eine Melodie wiedergegeben. Im Gegensatz zu den typischerweise beim Sprechen und Singen aktivierten Hirnarealen zeigt sich jedoch im Bereich des intrasylvischen Kortex eine hämodynamische Aktivierung ausschließlich bei Ausführung im lautierenden Modus. Darüber hinaus konnte eine ausgeprägte Lateralisierung mit Aktivierung der linken vorderen Insel bei Wiedergabe der Monatsnamen und der rechten vorderen Insel bei Wiedergabe der beschriebenen Melodie beobachtet werden.

Summary

Clinical and functional imaging data indicate that the left anterior insula has been assumed to support pre-articulatory functions of speech motor control such as the ‘‘programming’’ of vocal tract gestures. In order to further elucidate this model, we investigated both overt (aloud) and covert (silent) production of highly overlearned word strings (‘‘automatic speech’’), based on the suggestion that ‘‘inner speech’’ might provide a ‘‘window’’ into preparatory motor activities. As a control condition, subjects were asked to reproduce a non-lyrical tune. In contrast to hemodynamic responses within motor cortex and cerebellum, activation of the intrasylvian cortex turned out to be bound to overt task performance. Whereas (overt) speech tasks predominantly elicit activation within left anterior insula, reproduction of a non-lyrical tune yielded an opposite response pattern.

Schlüsselwörter

Funktionelle Kernspintomografie (fMRT) - zerebrale Organisation - Sprachproduktion - vordere Insel

Keywords

Functional magnetic resonance imaging (fMRI) - cerebral organisation - speech production - anterior insula
 

  • Literatur

  • 1 Ackermann H, Hertrich I, Daum I, Scharf G, Spieker S. Kinematic analysis of articulatory movements in central motor disorders. Movement Disorders 1997; 12: 1019-1027.
    CrossrefPubMedGoogle Scholar
  • 2 Ackermann H, Wildgruber D, Daum I, Grodd W. Does the cerebellum contribute to cognitive aspects of speech production? A functional magnetic resonance imaging (fMRI) study in humans. Neuroscience Letters 1998; 247: 187-190.
    CrossrefPubMedGoogle Scholar
  • 3 Ackermann H. Acquired disorders of articulation: Classification and intervention. In Fabbro F. (Ed.) Concise encyclopedia of language pathology. Amsterdam: Elsevier; 1999: 261-268.
    Google Scholar
  • 4 Ackermann H, Riecker A, Mathiak K, Erb M, Grodd W, Wildgruber D. Rate-dependent activation of a prefrontal-insular-cerebellar network during passive listening to trains of click stimuli: An fMRI study. NeuroReport 2001; 12: 4087-4092.
    CrossrefPubMedGoogle Scholar
  • 5 Ackermann H, Riecker A. The contribution of the insula to motor aspects of speech production: a review and a hypothesis. Brain and Language 2004; 89: 320-328.
    CrossrefPubMedGoogle Scholar
  • 6 Alexander MP, Benson DF, Stuss DT. Frontal lobes and language. Brain and Language 1989; 37: 656-691.
    CrossrefPubMedGoogle Scholar
  • 7 Augustine JR. The insular lobe in primates including humans. Neurological Research 1985; 7: 2-10.
    CrossrefPubMedGoogle Scholar
  • 8 Barlow SM, Farley GR. Neurophysiology of speech. In Kuehn DP, Lemme ML, Baumgartner JM. (Eds.). Neural bases of speech, hearing, and language. Boston, MA: College-Hill; 1989: 146-200.
    Google Scholar
  • 9 Belin P, Van Eeckhout P, Zilbovicius M, Remy P, Francois C, Guillaume S, Chain F, Rancurel G, Samson Y. Recovery from nonfluent aphasia after melodic intonation therapy: a PET study. Neurology 1996; 47: 1504-1511.
    CrossrefPubMedGoogle Scholar
  • 10 Botez MI, Wertheim N. Expressive aphasia and amusia following right frontal lesion in a righthanded man. Brain 1959; 82: 186-202.
    CrossrefPubMedGoogle Scholar
  • 11 Brooks VB. The neural basis of motor control. New York, NY: Oxford University Press; 1986
    Google Scholar
  • 12 Calvert GA. Crossmodal processing in the human brain: Insights from functional neuroimaging studies. Cerebral Cortex 2001; 11: 1110-1123.
    CrossrefPubMedGoogle Scholar
  • 13 Cereda C, Ghika J, Maeder P, Bogousslavsky J. Strokes restricted to the insular cortex. Neurology 2002; 59: 1950-1955.
    CrossrefPubMedGoogle Scholar
  • 14 Daniels SK, Foundas AL. The role of the insular cortex in dysphagia. Dysphagia 1997; 12: 146-156.
    CrossrefPubMedGoogle Scholar
  • 15 Dronkers NF. A new brain region for coordinating speech articulation. Nature 1996; 384: 159-161.
    CrossrefPubMedGoogle Scholar
  • 16 Duffau H, Bauchet L, Lehericy S, Capelle L. Functional compensation of the left dominant insula for language. NeuroReport 2001; 12: 2159-2163.
    CrossrefPubMedGoogle Scholar
  • 17 Epstein CM, Meador KJ, Loring DW, Wright RJ, Weissman JD, Sheppard S, Lah JJ, Puhalovich F, Gaitan L, Davey KR. Localization and characterization of speech arrest during transcranial magnetic stimulation. Clinical Neurophysiology 1999; 110: 1073-1079.
    CrossrefPubMedGoogle Scholar
  • 18 Etgen T, Winbeck K, Conrad B, Sander D. Hemiballism with insular infarction as first manifestation. Journal of Neurology 2003; 250: 226-229.
    CrossrefPubMedGoogle Scholar
  • 19 Goodglass H. Understanding aphasia. San Diego, CA: Academic Press; 1993
    Google Scholar
  • 20 Hardcastle W. Some aspects of speech production under controlled conditions of oral anaesthesia and auditory masking. Journal of Phonetics 1975; 3: 197-214.
    Google Scholar
  • 21 Hillis AE, Work M, Barker PB, Jacobs MA, Breese EL, Maurer K. Re-examining the brain regions crucial for orchestrating speech articulation. Brain 2004; 127: 1479-1487.
    CrossrefPubMedGoogle Scholar
  • 22 Holodny AI, Schulder M, Liu WC, Maldjian JA, Kalnin AJ. Decreased BOLD functional MR activation of the motor and sensory cortices adjacent to a glioblastoma multiforme: implications for image-guided neurorysurgery. American Journal of Neuroradiology 1999; 20: 609-612.
    PubMedGoogle Scholar
  • 23 Hopf HC, Müller-Forell W, Hopf NJ. Localization of emotional and volitional facial paresis. Neurology 1992; 42: 1918-1923.
    CrossrefPubMedGoogle Scholar
  • 24 Ivry RB, Robertson LC. The two sides of perception. Cambridge, MA: MIT Press; 1998
    Google Scholar
  • 25 Jeannerod M. The representing brain: Neural correlates of motor intention and imagery. Behavioral and Brain Sciences 1994; 17: 187-245.
    CrossrefGoogle Scholar
  • 26 Lang FF, Olansen NE, De Monte F, Gokaslan ZL, Holland EC, Kalhorn C, Sawaya R. Surgical resection of intrinsic insular tumors: Complication avoidance. Journal of Neurosurgery 2001; 95: 638-650.
    CrossrefPubMedGoogle Scholar
  • 27 Levelt WJM. Speaking: From intention to articulation. Cambridge, MA: MIT Press; 1989
    Google Scholar
  • 28 Levelt WJM, Wheeldon L. Do speakers have access to a mental syllabary?. Cognition 1994; 50: 239-269.
    CrossrefPubMedGoogle Scholar
  • 29 Levelt WJM, Roelofs A, Meyer AS. A theory of lexical access in speech production. Behavioral and Brain Sciences 1999; 22: 1-75.
    PubMedGoogle Scholar
  • 30 Levelt WJM. Spoken word production: A theory of lexical access. Proceedings of the National Academy of Sciences USA 2001; 98: 13464-13471.
    CrossrefPubMedGoogle Scholar
  • 31 Marien P, Pickut BA, Engelborghs S, Martin JJ, De Deyn PP. Phonological agraphia following a focal anterior insulo-opercular infarction. Neuropsychologia 2001; 39: 845-855.
    CrossrefPubMedGoogle Scholar
  • 32 Mulderink TA, Gitelman DR, Mesulam MM, Parrish TB. On the use of caffeine as a contrast booster for BOLD fMRI studies. NeuroImage 2002; 15: 37-44.
    CrossrefPubMedGoogle Scholar
  • 33 Nagao M, Takeda K, Komori T, Isozaki E, Hirai S. Apraxia of speech associated with an infarct in the precentral gyrus of the insula. Neuroradiology 1999; 41: 356-357.
    CrossrefPubMedGoogle Scholar
  • 34 Nelson L, Lapsiwala S, Haughton VM, Noyes J, Sadrzadeh AH, Moritz CH, Meyerand ME, Badie B. Preoperative mapping of the supplementary motor area in patients harboring tumors in the medial frontal lobe. Journal of Neurosurgery 2002; 97: 1108-1114.
    CrossrefPubMedGoogle Scholar
  • 35 Ojemann GA. Cortical stimulation and recording in language. In Kertesz A. (Ed.). Localization and neuroimaging in neuropsychology. San Diego, CA: Academic Press; 1994: 35-55.
    Google Scholar
  • 36 Penfield W, Roberts L. Speech and brain mechanisms. Princeton, NJ: Princeton University Press; 1959
    Google Scholar
  • 37 Peretz I. Processing of local and global musical information by unilateral brain-damaged patients. Brain 1990; 113: 1185-1205.
    CrossrefPubMedGoogle Scholar
  • 38 Petersen SE, Fox PT, Posner MI, Mintun M, Raichle ME. Positron emission tomographic studies of the cortical anatomy of single-word processing. Nature 1988; 331: 585-589.
    CrossrefPubMedGoogle Scholar
  • 39 Petersen SE, Fox PT, Posner MI, Mintun M, Raichle ME. Positron emission tomographic studies of the processing of single words. Journal of Cognitive Neuroscience 1989; 1: 153-170.
    CrossrefPubMedGoogle Scholar
  • 40 Poeppel D, Guillemin A, Thompson J, Fritz J, Bavelier D, Braun A. Auditory lexical decision, categorical perception, and FM direction discrimination differentially engage left and right auditory cortex. Neuropsychologia 2004; 42: 183-200.
    CrossrefPubMedGoogle Scholar
  • 41 Pouratian N, Bookheimer SY, Rex DE, Martin NA, Toga AW. Utility of preoperative functional magnetic resonance imaging for identifying language cortices in patients with vascular malformations. Journal of Neurosurgery 2002; 97: 21-32.
    CrossrefPubMedGoogle Scholar
  • 42 Richman B. Subhuman vocalizations. Current Anthropology 1993; 34: 721-722.
    Google Scholar
  • 43 Riecker A, Ackermann H, Wildgruber D, Dogil G, Grodd W. Opposite hemispheric lateralization effects during speaking and singing at motor cortex, insula and cerebellum. NeuroReport 2000; 11: 1997-2000.
    CrossrefPubMedGoogle Scholar
  • 44 Riecker A, Wildgruber D, Dogil G, Grodd W, Ackermann H. Hemispheric Lateralization Effects of Rhythm Implementation during Syllable Repetitions: An fMRI Study. NeuroImage 2002; 16: 169-176.
    CrossrefPubMedGoogle Scholar
  • 45 Riecker A, Wildgruber D, Grodd W, Ackermann H. Reorganization of speech production at the motor cortex and cerebellum following capsular infarction: a follow-up functional magnetic resonance imaging study. Neurocase 2002; 8: 417-423.
    CrossrefPubMedGoogle Scholar
  • 46 Riecker A, Wildgruber D, Mathiak K, Grodd W, Ackermann H. Parametric analysis of rate-dependent hemodynamic response functions of cortical and subcortical brain structures during auditorily cued finger tapping: a fMRI study. Neuroimage 2003; 18: 731-739.
    CrossrefPubMedGoogle Scholar
  • 47 Riecker A, Mathiak K, Wildgruber D, Erb M, Hertrich I, Grodd W, Ackermann H. fMRI reveals two distinct cerebral networks subserving speech motor control. Neurology 2005; 64: 700-706.
    CrossrefPubMedGoogle Scholar
  • 48 Sakurai Y, Momose T, Iwata M, Sudo Y, Ohtomo K, Kanazawa I. Cortical activity associated with vocalization and reading proper. Brain Research Cognitive Brain Reseach 2001; 12: 161-165.
    Google Scholar
  • 49 Schiff HB, Alexander MP, Naeser MA, Galaburda M. Aphemia: clinical-anatomic correlations. Archives of Neurology 1983; 40: 720-727.
    CrossrefPubMedGoogle Scholar
  • 50 Scott CM, Ringel RL. Articulation without oral sensory control. Journal of Speech and Hearing Research 1971; 14: 804-818.
    CrossrefPubMedGoogle Scholar
  • 51 Shuren J. Insula and aphasia. Journal of Neurology 1993; 240: 216-218.
    CrossrefPubMedGoogle Scholar
  • 52 Thiel A, Herholz K, Koyuncu A, Ghaemi M, Kracht LW, Habedank B, Heiss W-D. Plasticity of language networks in patients with brain tumors: A positron emission tomography activation study. Annals of Neurology 2001; 50: 620-629.
    CrossrefPubMedGoogle Scholar
  • 53 Ulmer JL, Krouwer HG, Mueller WM, Ugurel MS, Kocak M, Mark LP. Pseudo-reorganization of language cortical function at fMR imaging: a consequence of tumor-induced neurovascular uncoupling. American Journal of Neuroradiology 2003; 24: 213-217.
    PubMedGoogle Scholar
  • 54 Van Lancker D. Cerebral lateralization of pitch cues in the linguistic signal. International Journal of Human Communication 1980; 13: 227-277.
    Google Scholar
  • 55 Weller M. Anterior opercular cortex lesions cause dissociated lower cranial nerve palsies and anarthria but no aphasia: Foix-Chavany-Marie syndrome and ,,automatic voluntary dissociation“ revisited. Journal of Neurology 1993; 240: 199-208.
    CrossrefPubMedGoogle Scholar
  • 56 Wildgruber D, Ackermann H, Grodd W. Differential contributions of motor cortex, basal ganglia, and cerebellum to speech motor control: Effects of syllable repetition rate evaluated by fMRI. NeuroImage 2000; 13: 101-109.
    Google Scholar
  • 57 Wildgruber D, Hertrich I, Riecker A, Erb M, Anders S, Grodd W, Ackermann H. Distinct Frontal Regions Subserve Evaluation of Linguistic and Affective Aspects of Intonation. Cerebral Cortex 2004; 14: 1384-1389.
    CrossrefPubMedGoogle Scholar
  • 58 Zatorre RJ, Evans AC, Meyer E, Gjedde A. Lateralization of phonetic and pitch discrimination in speech processing. Science 1992; 256: 846-849.
    CrossrefPubMedGoogle Scholar
  • 59 Ziegler W. Psycholinguistic and motor theories of apraxia of speech. Seminars in Speech and Language 2002; 23: 231-243.
    Article in Thieme ConnectPubMedGoogle Scholar