Verträglichkeit von modernen Antipsychotika

E. Rüther

doi:10.1055/s-0038-1626447

Nervenheilkunde, Inhaltsverzeichnis

Nervenheilkunde 2006; 25(03): 170-176
DOI: 10.1055/s-0038-1626447

Original- und Übersichtsarbeiten - Original and Review Articles

Schattauer GmbH

Verträglichkeit von modernen Antipsychotika

Tolerability of modern antipsychotics

E. Rüther

¹Abteilung Psychiatrie und Psychotherapie Bereich Humanmedizin, Georg-August-Universität Göttingen

› Institutsangaben

Abstract

Zusammenfassung

Mit den Antipsychotika der zweiten Generation wurden die Möglichkeiten einer Therapie der Schizophrenie maßgeblich erweitert: Die modernen Substanzen zeichnen sich im Vergleich zu den konventionellen Antipsychotika insbesondere durch günstigere Effekte auf die negativen und depressiven Symptome aus und weisen zudem ein geringeres Risiko für extrapyramidalmotorische Symptome auf. Auf Grund ihres Einflusses auf verschiedene Neurotransmittersysteme können unter den modernen Antipsychotika aber, je nach Wirkstoff, unterschiedliche unerwünschte Arzneimittelwirkungen und Verträglichkeitsprobleme relevant werden. Dies erfordert eine sorgfältige Auswahl und ein engmaschiges Monitoring einer adäquaten Antipsychotikatherapie bei Patienten mit Schizophrenie.

Summary

With the second generation antipsychotics the options for treating schizophrenia were broadened considerably: in comparison to the conventional antipsychotics the modern substances show particularly more favourable effects on the negative and depressive symptoms and have, in addition, a lower risk of extrapyramidal side effects. However, because of the different influences on the various neurotransmitter systems other undesired drug effects and tolerance problems can, depending on the substance, become more relevant. Therefore, the appropriate treatment with modern antipsychotics has to be selected carefully for each patient and a close meshed monitoring of antipsychotic therapy has to be established.

Schlüsselwörter

Atypische Antipsychotika - Schizophrenie - Verträglichkeit - Sicherheit - Nebenwirkungen

Keywords

Atypical antipsychotics - schizophrenia - tolerability - safety - side effects

Volltext

Referenzen

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