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DOI: 10.1055/s-0038-1624330
A Comparative Study of Brain Uptake and Early Kinetics of 99mTc-dl HM-PAO and other PnAO Derivatives in Baboons
Publication History
Received:
16 June 1986
Publication Date:
12 January 2018 (online)
![](https://www.thieme-connect.de/media/10.1055-s-00034924/198604/lookinside/thumbnails/10-1055-s-0038-1624330-1.jpg)
Derivatives of propylene-amine-oxime (PnAO) have been synthesized which form a neutral lipid-soluble complex with 99mTc and can be supplied as freezedried kits. The complexes cross the intact blood-brain barrier. This report shows the brain uptake, early kinetics and biodistribution in normal adult baboons of 5 99m Tc-PnAO derivatives and 2 isomers of one of the tested derivatives (HM-PAO). The brain uptake of the favoured dl-isomer of HM-PAO reaches its maximum of 4.3% (whole brain/whole body) 1 min p. i. and a clearance of less than 8% was observed 23 min p. i.
Zusammenfassung
Derivate des Propylen-Amin-Oxim (PnAO), die einen neutralen und lipidlöslichen Komplex bilden, wurden synthetisiert. Sie können als gefriergetrockneter Kit geliefert werden. Die Komplexe passieren die intakte Blut- Hirn-Schranke. Diese Arbeit zeigt die Aufnahme von 5 99m Tc-PnAO-Derivaten und von 2 Isomeren des einen der getesteten Derivate (HM-PAO) ins Gehirn und deren frühe Kinetik und Biodistribution in normalen erwachsenen Pavianen. Die Hirnaktivität des favorisierten dl-Isomers des HM-PAO erreicht ihr Maximum von 4,3% (Gesamthirn/ Gesamtkörper) in 1 min p.i. Die beobachtete Clearance aus dem Gehirn betrug nach 23 Minuten p.i. weniger als 8%.
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