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DOI: 10.1055/s-0038-1624328
Tumor Markers as Target Substances in the Radioimmunological Detection of Malignancies[*]
Publication History
Received:
19 June 1986
Publication Date:
12 January 2018 (online)
![](https://www.thieme-connect.de/media/10.1055-s-00034924/198604/lookinside/thumbnails/10-1055-s-0038-1624328-1.jpg)
Although none of the known tumor markers, including the relatively new ones characterized by monoclonal antibodies, are sufficiently sensitive or specific as to be useful in the primary diagnosis of incipient malignancies, many of them turned out, nevertheless, to be of great clinical importance: their main field of interest lies in the surveillance of the already diagnosed patient in the post-operative phase. More recently some of them, e.g. tumor proteins like CEA and AFP, hormones (HCG), some enzymes, and monoclonal antibodycharacterized membrane components, are used also as target antigens for the radioimmuno-detection (RAID) of carcinomas and their metastases. Most of the tumor marker antigens were already successfully used as targets for tumor imaging with radiolabeled antibodies; however, many immunological and technical problems still remain to be resolved.
Zusammenfassung
Obwohl keiner der bekannten Tumormarker einschließlich der relativ neuen, durch monoklonale Antikörper charakterisierten Tumormarker, sensitiv oder spezifisch genug ist, um bei der Primärdiagnose früher Malignome nützlich sein zu können, sind doch viele von ihnen von großer klinischer Bedeutung: Ihr Hauptanwendungsgebiet liegt in der Überwachung des bereits diagnostizierten Patienten in der postoperativen Phase. Seit einiger Zeit werden einige von ihnen, z.B. Tumorproteine wie CEA und AFP, Hormone (HCG), verschiedene Enzyme und durch monoklonale Antikörper charakterisierte Membrankomponenten als Zielantigene für die Radioimmunlokalisation von Karzinomen und ihren Metastasen verwandt. Viele der Tumormarkerantigene wur-den bereits erfolgreich als Targets für die Tumordarstellung mit radioisotopengekoppelten Antikörpern gebraucht; allerdings bleiben noch viele immunologische und technische Probleme zu lösen.
* Presented at the Symposion on “Monoclonal Antibodies in Nuclear Medicine” in Freiburg i. Br., May 1-3, 1986.
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REFERENCES
- 1 Armitage N. C.. et al. The localization of an anti-tumor monoclonal antibody (791T/ 36) in gastrointestinal tumors. Brit. J. Surg 1984; 71: 407-12.
- 2 Ballou B. et al. Tumor location using F(ab’) 2 from a monoclonal IgM antibody: Pharmacokinetics. J. nucl. Med 1985; 26: 283-92.
- 3 Baum R. P.. et al. Immunszintigraphie kolorektaler Tumoren mit 131J-markierten monoklonalen Antikörpern (CA19-9/anti CEA): Erste Ergebnisse. NUC-Comp 1985; 16: 121.
- 4 Berche C. et al. Tomoscintigraphy for detecting gastrointestinal and medullary thyroid cancers: First clinical results using radiolabeled monoclonal antibodies against carcinoembryonic antigen. Brit. J. Cancer 1982; 285: 1447-51.
- 5 Breitbach G. P.. et al. Simultane Tumormarkerbestimmung (CA 125, CA 15-3, CEA und TPA) bei gynäkologischen Tumoren einschließlich Mammakarzinomen. Int. Symp. “Monoklonale Antikörper der klin. Onkologie”, Homburg/Saar, Nov. 1985..
- 6 Buraggi G. L.. et al. Imaging with 131Ilabelled monoclonal antibodies to a high molecular weight melanoma antigen: Efficacy of whole Ig and its Fab-2 fragments. Cancer. Res 1985; 45: 3378-87.
- 7 Del Villano B. C.. et al. Radioimmunometric assay for a monoclonal antibodydefined tumor marker, CA 19-9. Clin. Chem 1983; 29: 549-52.
- 8 Dillmann R. O.. et al. Lack of radioimmunodetection and complications associated with monoclonal anti-carcinoembryonic antigen antibody crossreacting with an antigen on circulating cells. Cancer Res 1984; 411: 2213-8.
- 9 Goldenberg D. M.. et al. Photoscan localization of GW-39 tumors in hamsters using radiolabeled anti-carcinoembryonic antigen immunoglobulin. Cancer Res 1974; 34: 1-9.
- 10 Goldenberg D. M.. et al. Use of radiolabeled antibodies to carcinoembryonic antigen for the detection and localization of diverse cancers by external photoscanning. New Engl. J. Med 1978; 298: 1384-8.
- 11 Goldenberg D. M., Kim E. E., Deland F. H.. Human chorionic gonadotropin radioantibodies in the radioimmunodetection of cancer and for the disclosure of occult metastases. Proc. natl. Acad. Sei. (USA) 1981; 78: 7754-8.
- 12 Granowska M. et al. Ovarian cancer: Diagnosis using 123I monoclonal antibody in comparison with surgical findings. Nucl. Med. Commun 1984; 05: 485-99.
- 13 Halpern S. E., Dillman R. O.. Radioimmunodetection with monoclonal antibodies against prostatic acid phosphatase. In: Nuclear Medicine in Clinical Oncology. Winkler C. 164-70 Springer, Berlin – Heidelberg – New York – Tokyo: 1986
- 14 Hasall A. K.. et al. Localization of malignant germ cell tumors by external scanning after injection by radiolabeled anti-alpha-fetoprotein antibody. Brit, med. J 1981; 283: 942-4.
- 15 Hyderman E. et al. A new antigen on the epithelial membrane: Its immunoperoxidase localization in normal and neoplastic tissues. J. clin. Pathol 1979; 32: 35-9.
- 16 Kim E. E.. et al. Radioimmunodetection of cancer with radio-labelled antibodies to alpha-fetoprotein. Cancer Res 1980; 40: 3008-12.
- 17 Larson S. M.. et al. Localization of 131Ilabelled p97 specific Fab fragments in human melanoma as a basis for radiotherapy. J. clin. Immunol 1983; 72: 1201-21.
- 18 Mach J. P.. et al. In vivo localization of radiolabeled antibodies to carcinoembryonic antigen in human colon carcinoma grafted onto nude mice. Nature 1974; 248: 704-6.
- 19 Paiva J. et al. Immunohistological localization of placental-like alkaline phosphatase in testis and germ-cell tumors using monoclonal antibodies. Amer. J. Pathol 1983; 111: 156-65.
- 20 Pimm M. W.. et al. In vivo localization of antiosteogenic sarcoma 791T monoclonal antibody in osteogenic sarcoma xenografts. Intern. J. Cancer 1982; 30: 75-85.
- 21 von Kleist S. The clinical value of the tumor markers CA 19/9 and carcinoembryonic antigen (CEA) in colorectal carcinomas: A critical comparison. Intern. J. biol. Markers. 1986 01. in press.
- 22 Williams M. R.. The use of monoclonal antibody 791T/36 in the immunoscintigraphy of primary and metastatic carcinoma of the breast. Clin. Oncol 1984; 10: 375-81.