Download PDF
Nuklearmedizin 1984; 23(06): 317-319
DOI: 10.1055/s-0038-1624263
Originalarbeiten — Original Articles
Schattauer GmbH

Scintigraphic Detection of Experimental Myocardial Infarction with 99mTc-2,3-Dimercaptosuccinic Acid

Szintigraphischer Nachweis experimenteller Myokardinfarkte mit 99mTc2,3-Dimerkapto-Bemsteinsäure
F. Duška
1   From the Department of Normal and Pathological Physiology, of Nuclear Medicine and of Morphological Sciences, Charles University Faculty of Medicine, Hradec Králové, ČSSR
,
J. Novák
1   From the Department of Normal and Pathological Physiology, of Nuclear Medicine and of Morphological Sciences, Charles University Faculty of Medicine, Hradec Králové, ČSSR
,
Y. Mazurová
1   From the Department of Normal and Pathological Physiology, of Nuclear Medicine and of Morphological Sciences, Charles University Faculty of Medicine, Hradec Králové, ČSSR
,
J. Kubíček
1   From the Department of Normal and Pathological Physiology, of Nuclear Medicine and of Morphological Sciences, Charles University Faculty of Medicine, Hradec Králové, ČSSR
,
J. Yižd’a
1   From the Department of Normal and Pathological Physiology, of Nuclear Medicine and of Morphological Sciences, Charles University Faculty of Medicine, Hradec Králové, ČSSR
,
P. Kafka
1   From the Department of Normal and Pathological Physiology, of Nuclear Medicine and of Morphological Sciences, Charles University Faculty of Medicine, Hradec Králové, ČSSR
,
O. Veverková
1   From the Department of Normal and Pathological Physiology, of Nuclear Medicine and of Morphological Sciences, Charles University Faculty of Medicine, Hradec Králové, ČSSR
› Author Affiliations
Further Information

Publication History

Received: 20 January 1984

14 May 1984

Publication Date:
11 January 2018 (online)

Also available at
    Permissions and Reprints

Summary

Acute myocardial infarctions were produced by ligature of the left frontal descending coronary artery in 9 dogs. The possibility of scintigraphic imaging with 99mTc-DMSA 4 hrs after intravenous administration was studied. The infarctions were 4, 24 and 48 hrs old. The in vivo scan was positive in only one dog with a 4-hr old infarction. The in vivo scans were confirmed by the analysis of the radioactivity in tissue samples. The accumulation of the radiopharmaceutical increased slightly in 48-hr old lesions; however, this increase was not sufficient for a positive scintigraphic finding. Thus, we do not recommend 99mTc-DMSA for clinical use in acute lesions.

Zusammenfassung

Akute Myokardinfarkte wurden operativ durch Unterbindung der linken frontalen absteigenden Koronararterie bei 9 Hunden hervorgerufen. Die Möglichkeit einer szintigraphischen Darstellung mit 99mTc-DMSA 4 Std. nach intravenöser Verabreichung wurde untersucht. Die Infarkte waren 4, 24 und 48 Std. alt. Lediglich bei einem Hund mit einem 4 Std. alten Infarkt war das Szintigramm in vivo positiv. Diese Szintigramme in vivo wurden durch eine Analyse der Radioaktivität in Gewebsproben be stätigt. Die Anwendung des Radiopharmazeutikums nahm geringfügig bei 48 Std. alten Läsionen zu, dieser Anstieg war jedoch unzureichend für einen positiven szintigraphischen Befund. Wir empfehlen daher 99mTcDMSA nicht zur klinischen Anwendung bei frischen Läsionen.

 

  • References

  • 1 Daly M. J., Milutirovic J., Rudd T. G. The normal 99mTc-DMSA renal image. Radiology 1978; 128: 701-4.
    CrossrefPubMedGoogle Scholar
  • 2 Gorten R. J., Hardy L. B., Melrew B. H., Stokes J. R., Lumb G. D., Durham N. C. The selective uptake of Hg203-chlormerodrin in experimentally produced myocardial infarcts. Amer. Heart J. 1966; 72: 71-8.
    CrossrefPubMedGoogle Scholar
  • 3 Handmaker H. B., Yong W., Lowenstein J. M. Clinical experience with 99m Tc-DMSA (dimercaptosuccinic acid), a new renal imaging agent. J. nucl. Med. 1975; 16: 28-32.
    PubMedGoogle Scholar
  • 4 Holman B. L., Davis M. A., Hanson R. N. Myocardial infarct imaging with technetium-labelled complexes. Semin. nucl. Med. 1977; 07: 29-35.
    CrossrefPubMedGoogle Scholar
  • 5 Holman B. L., Wynne J. Infarct avid (hot spot) myocardial scintigraphy. Radiol. Clin. North Amer. 1980; 18: 487-99.
    Google Scholar
  • 6 Iodine J., Fliegel C. P., Davis M. A., Treves S., Eldh P. Detection and localization of experimental myocardial infarction with 99mTc-tetracycline. J. nucl. Med. 1973; 14: 595-9.
    PubMedGoogle Scholar
  • 7 Karlsberg R. P., Milne N., Lyons K. P., Aronov W. S. Imaging of experimental myocardial infarction with technetium99m, 2,3-dimercaptosuccinic acid. J. nucl. Med. 1981; 22: 253-7.
    PubMedGoogle Scholar
  • 8 Kubíček J., Vižd’a J., Duška F. Use of 99mTc-labelled pyrophosphate in the scintigraphic diagnosis of myocardial infarction. Nucl. Med. 1977; 16: 147-50.
    Google Scholar