Effect of Two Graded Doses of Whole-Body X-Irradiation and Radioprotection by the Use of S-Phenethyl Formamidino 4 (N-Ethyl Isothioamide) Morpholine Dihydrochloride
Wirkung von zwei Ganzkörper-Röntgenbestrahlungen und des Strahlenschutzes durch S-Phenethylformamidin-4(Näthyl-isothiamid)-Morpholindihydrochlorid
S. S. Hasan
1
From the Department of Zoology, Garhwal University Campus, Pauri-Garhwal, India
,
P. K. Chaturvedi
1
From the Department of Zoology, Garhwal University Campus, Pauri-Garhwal, India
,
S. N. Pandeya
*
The Department of Pharmaceutics, Institute of Technology, Banaras Hindu University, Varanasi, India
› InstitutsangabenThe authors are grateful to the Council of Scientific and Industrial Research, New Delhi (India) for financial assistance. Our sincere thanks are due to Dr. A. K. Kautse, Radiologist, District Hospital, Pauri-Garhwal, for providing X-ray facilities.
The protection offered by a newly synthesized compound (S-phenethyl-formamidino-4(N-ethyl isothioamide) morpholine dihydrochloride) against radiation effects on DNA, RNA and protein biosynthetic processes in the brain, and on metabolites of 5-HT and nor-adrenalin, i.e., 5-HIAA and VMA, in the urine, including the radiobiological damage to thyroid and testes, was evaluated. The use of the compound prior to irradiation prevented radiation-induced changes in the thyroid and testes. The radiation-induced alterations in the pattern of DNA, RNA, protein in the brain, and in 5-HIAA and VMA in urine could be averted by treatment with this compound prior to each dose of X-irradiation.
Es wurde die Schutzwirkung einer neu synthetisierten Verbindung (S-Phenethylformamidin-4(N-äthylisothiamid)-Morpholindihydrochlorid gegen Strahleneffekte auf die DNA, RNA und die Biosynthese von Proteinen im Gehirn und auf die Stoffwechselprodukte des 5-HT und des Noradrenalins, d.h. 5-HIAA und VMA, im Harn sowie auf die radiobiologische Schädigung der Schilddrüse und des Testes ausgewertet. Die Verwendung dieser Verbindung vor den beiden Bestrahlungsdosen verhinderte strahlenbedingte Veränderungen in der Schilddrüse und des Testes sowie in der Zusammensetzung von DNA, RNA und Proteinen im Gehirn und 5-HIAA und VMA im Harn.
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