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DOI: 10.1055/s-0038-1624000
Moyamoya syndrome: Impaired hemodynamics on ECD SPECT after EEG controlled hyperventilation
Moya-Moya-Syndrom: Beeinträchtigte Hämodynamik in der ECD-SPECT nach EEG-kontrollierter HyperventilationPublikationsverlauf
Received:
20. August 2001
in revised form:
28. September 2001
Publikationsdatum:
10. Januar 2018 (online)
![](https://www.thieme-connect.de/media/10.1055-s-00034924/200201/lookinside/thumbnails/10-1055-s-0038-1624000_de-1.jpg)
Summary
Background and purpose: Ischemic symptoms in children with Moyamoya syndrome are typically provoked by hyperventilation (HV) and are accompanied by the “re-build-up” phenomenon in EEG. The value of scintigraphic detection of HV-provoked perfusion deficits remains to be elucidated. Patients and methods: In seven children with Moyamoya syndrome regional cerebral blood flow was assessed by 99mTc-ethyl-cysteine-dimer (ECD) single photon emission computed tomography (SPECT) after HV and under baseline conditions to identify ischemia prone regions. Results: Regional marked hypoperfusion after HV was found in all patients. Predominant perfusion deficits were detected in the frontal lobes. Conclusion: ECD SPECT is a potential tool for the preoperative evaluation of cerebral hemodynamics and for monitoring angiosurgical therapies in Moyamoya disease.
Zusammenfassung
Hintergrund und Ziel: Ischämische Symptome bei Kindern mit Moya-Moya-Erkrankung werden typischerweise durch Hyperventilation provoziert und vom Re-build-up-Phänomen im EEG begleitet. Patienten und Methoden: Bei sieben Kindern mit Moya-Moya-Syndrom wurde der regionale Blutfluss mit der 99mTc-Ethylcysteinatdimer-( ECD-)Single-Photon-Emissionscomputertomographie (SPECT) nach Hyperventilation und unter Basisbedingungen bestimmt, um ischämiegefährdete Regionen zu identifizieren. Ergebnisse: Eine regional ausgeprägte Hypoperfusion nach Hyperventilation wurde bei allen Patienten gefunden. Vorwiegend kamen Perfusionsdefekte in den Frontallappen zur Darstellung. Schlussfolgerung: ECD-SPECT eignet sich potenziell für die präoperative Evaluation der zerebralen Hämodynamik und für die Verlaufskontrolle nach gefäßchirurgischer Therapie der Moya-Moya-Erkrankung.
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