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Tierarztl Prax Ausg K Kleintiere Heimtiere 2013; 41(03): 198-202
DOI: 10.1055/s-0038-1623700
Case Report
Schattauer GmbH

Rubber jaw in a Weimaraner dog due to juvenile nephropathy

A case without evidence for genetic involvementOsteodystrophia fibrosa bei einem Weimaranerwelpen mit juveniler NephropathieEin Fall ohne Hinweis auf eine genetische Ursache
L. Brachthäuser
1   Institut für Veterinär-Pathologie, Justus-Liebig-Universität Gießen, Germany
,
C.-H. Pingen
2   Tierärztliche Praxis Gut Bergerhof, Pulheim-Freimersdorf, Germany
,
W. Hecht
1   Institut für Veterinär-Pathologie, Justus-Liebig-Universität Gießen, Germany
,
M. Reinacher
1   Institut für Veterinär-Pathologie, Justus-Liebig-Universität Gießen, Germany
› Institutsangaben
Weitere Informationen

Publikationsverlauf

Received: 20. März 2012

Accepted after revision: 15. Oktober 2012

Publikationsdatum:
08. Januar 2018 (online)

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Summary

The case of a 5-month-old male Weimaraner dog with severe osteodystrophia fibrosa (rubber jaw) and renal insufficiency is presented. Kidneys were smaller than normal with a granular cortical surface and a histopathological end-stage diagnosis consistent with juvenile nephropathy. Analysis of four described genetic mutations associated with Alport syndrome in dogs revealed no evidence for familiar inheritance in this dog.

Zusammenfassung

Vorgestellt wird der Fall eines 5 Monate alten Weimaraner-Welpen mit schwerer Osteodystrophia fibrosa (rubber jaw) und einer ausgeprägten Niereninsuffizienz. Bei der pathologischen Untersuchung zeigten sich bilateral Schrumpfnieren im Sinne einer juvenilen Nephropathie. Die molekularbiologische Untersuchung der vier bekannten, in der Literatur beschriebenen Genmutationen, die mit dem Alport-Syndrom des Hundes assoziiert sind, ergab keinen Hinweis auf eine hereditäre Pathogenese.

Key words

Osteodystrophia fibrosa - renal insufficiency - end-stage kidney - Alport syndrome

Schlüsselwörter

Osteodystrophia fibrosa - Niereninsuffizienz - Schrumpfniere - AlportSyndrom
 

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