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Tierarztl Prax Ausg K Kleintiere Heimtiere 2011; 39(01): 25-30
DOI: 10.1055/s-0037-1622566
Original Article
Schattauer GmbH

Effect of prednisolone and cetirizine on D. farinae and histamine-induced wheal and flare response in healthy dogs

Auswirkungen von Cetirizin und Prednisolon auf die Resultate des Intrakutantests bei gesunden Hunden
E. M. Temizel
1   Uludag University, Faculty of Veterinary, Department of Internal Medicine, Osmangazi, Bursa, Turkey
,
H. Cihan
1   Uludag University, Faculty of Veterinary, Department of Internal Medicine, Osmangazi, Bursa, Turkey
,
B. Akhtardanesh
2   Shahid Bahonar University, Faculty of Veterinary Medicine, Department of Small Animal Internal Medicine, Kerman, Iran
,
N. Aytug
1   Uludag University, Faculty of Veterinary, Department of Internal Medicine, Osmangazi, Bursa, Turkey
› Author Affiliations
Further Information

Publication History

Received: 05 December 2009

Accepted after revision: 23 July 2010

Publication Date:
05 January 2018 (online)

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Summary

Objective: Prednisolone and antihistamines are highly potent drugs in the treatment of atopic dermatitis and widely used in humans and dogs. In some atopic patients in which antihistamines, corticosteroids or other drugs have already been administered intradermal testing (IDT) may be necessary. The aim of the present study was to compare the effects of cetirizine and prednisolone on IDT results. Material and methods: Thirty healthy dogs (average age 5.9 ± 0.6 years) were randomly assigned to three groups. Treatment groups were administered prednisolone (1 mg/kg BW daily, tapering dosage; group I), cetirizine (1 mg/kg BW daily; group II) and placebo (group III) respectively for one week. In the second week, none of the dogs received any medications. IDT was performed prior to drug administration and results obtained were considered as the baseline response. Second and third IDTs were performed at the end of the first and second week, respectively. Results: In groups I and II IDT reactivity was reduced at the end of first week (p < 0.05). After drug discontinuation the reactivity almost returned to baseline at the end of the 2-week period, with the exception of the prednisolone group for D. farinae. Conclusion: Prednisolone and cetirizine have significant effects on IDT reactions and must be withdrawn by veterinary practitioners up to 2 weeks prior to IDT.

Zusammenfassung

Gegenstand und Ziel: Prednisolon und Antihistaminika stellen bei Menschen und Hunden mit atopischer Dermatitis die wirksamsten Medikamente dar. Bei einigen solcher kaninen Patienten, die bereits Antihistaminika, Glukokortikoide oder andere Medikamente erhalten haben, kann ein Intrakutantest erforderlich werden. Ziel der Studie war, die Auswirkungen von Cetirizin und Prednisolon auf die Resultate des Intrakutantests (IKT) zu vergleichen. Material und Methoden: Dreißig gesunde Hunde (mittleres Alter 5,9 ± 0,6 Jahre) wurden in drei Gruppen eingeteilt. Die Probanden erhielten eine Woche lang entweder Prednisolon (Initialdosis 1 mg/kg KM einmal täglich per os für 3 Tage, dann graduelle Dosisreduktion; Gruppe I), Cetirizin (1 mg/kg KM einmal täglich per os; Gruppe II) oder ein Plazebo (Gruppe III). In der zweiten Woche erfolgte keine Medikation. Der IKT wurde vor der einwöchigen Medikamentengabe (Ermittlung des Basiswerts) sowie nach 1 und 2 Wochen durchgeführt. Ergebnisse: In Gruppe I und II ergab sich am Ende der ersten Woche eine reduzierte Reaktion im IKT (p < 0,05). Nach der zweiten Woche hatten die Reaktionen fast wieder die Ausgangswerte erreicht. Dies galt nicht für die Reaktion auf D. farinae in Gruppe I. Schlussfolgerung: Prednisolon und Cetirizin können die Reaktionen im IKT erheblich beeinflussen. Die Medikation muss mindestens 2 Wochen vor einem IKT abgesetzt werden.

Keywords

Intradermal testing - atopia - antihistamines - canine

Schlüsselwörter

Intrakutantest - Atopie - Antihistaminika - Hund
 

  • References

  • 1 Anveden I, Lindberg M, Andersen KE, Bruze M, Isaksson M, Liden C. et al. Oral prednisone suppresses allergic but not irritant patch test reactions in individuals hypersensitive to nickel. Contact Dermatitis 2004; 50: 298-303.
    CrossrefPubMedSearch in Google Scholar
  • 2 Barata TL, Jacobson M, Walker S, Njuki F, Ying S, Randev P. et al. Effect of cetirizine and prednisolone on cellular infiltration and cytokine mRNA expression during allergen-induced late cutaneous responses. Clin Exp Allergy 1996; 26: 68-78.
    CrossrefPubMedSearch in Google Scholar
  • 3 Barbet JL, Halliwell REW. Duration of inhibition of immediate skin test reactivity by hydroxyzine hydrochloride in dogs. J Am Vet Med Assoc 1989; 11: 1565-1569.
    PubMedSearch in Google Scholar
  • 4 Barnes PJ. Corticosteroids, IgE, and atopy. J Clin Invest 2001; 107: 265-266.
    CrossrefPubMedSearch in Google Scholar
  • 5 Bizikova P, Papich MG, Olivry T. Hydroxyzine and cetirizine pharmacokinetics and pharmacodynamics after oral and intravenous administration of hydroxyzine to healthy dogs. Vet Dermatol 2008; 19: 348-357.
    CrossrefPubMedSearch in Google Scholar
  • 6 Carlotti DN, Costargent F. Analysis positive skin tests in 449 dogs with allergic dermatitis. Eur J Allergy Clin Immunol 1994; 04: 42-59.
    PubMedSearch in Google Scholar
  • 7 Charlesworth EN, Kagey SA, Norman PS, Lichtenstein LM. Effect of cetirizine on mast cell-mediator release and cellular traffic during the cutaneous late-phase reaction. J Allergy Clin Immunol 1989; 83: 905-912.
    CrossrefPubMedSearch in Google Scholar
  • 8 Cook CP, Scott DW, Miller WH, Kirker JE, Cobb SM. Treatment of canine atopic dermatitis with cetirizine, a second generation antihistamine: A single-blinded, placebo-controlled study. Can Vet J 2004; 45: 414-417.
    PubMedSearch in Google Scholar
  • 9 Coulie PJ, Ghys L, Rihoux JP. Inhibitory effects of orally or sublingually administered cetirizine on histamine-induced wheals and flares and their correlation with cetirizine plasma concentrations. J Int Med Res 1991; 19: 174-179.
    CrossrefPubMedSearch in Google Scholar
  • 10 De Boer DJ, Griffin CE. The ACVD task force on canine atopic dermatitis (XXI): Antihistamine pharmacotherapy. Vet Immunol Immunopathol 2001; 81: 323-329.
    CrossrefPubMedSearch in Google Scholar
  • 11 De Vos C, Maleux MR, Baltes E, Gobert J. Inhibition of histamine and allergen skin wheal by cetirizine in four animal species. Ann Allergy 1987; 59: 278-282.
    PubMedSearch in Google Scholar
  • 12 Demoly P, Michel FB, Bousquet J. In vivo methods for study of allergy: skin tests, techniques and interpretation In: Allergy Principles and Practice. 5th ed.. Middleton E, Reed CE, Ellis EF, et al. eds. St. Louis: Mosby; 1998: 430-439.
    Search in Google Scholar
  • 13 Des ARoches, Paradis L, Bougeard YH, Godard P, Bousquet J, Chanez P. Long-term oral corticosteroid therapy does not alter the results of immediate-type allergy skin prick tests. J Allergy Clin Immunol 1996; 98: 522-527.
    CrossrefPubMedSearch in Google Scholar
  • 14 Devalia JL, De Vos C, Hanotte F, Baltes E. A randomized, double-blind, crossover comparison among cetirizine, levocetirizine, and ucb 28557 on histamine-induced cutaneous responses in healthy adult volunteers. Allergy 2001; 56: 50-57.
    CrossrefPubMedSearch in Google Scholar
  • 15 Fadel R, David B, Herpin RN, Borgnon A, Rassemont R, Rihoux JP. In vivo effects of cetirizine on cutaneous reactivity and eosinophil migration induced by plateletactivating factor PAF-acether in man. J Allergy Clin Immunol 1990; 86: 314-320.
    CrossrefPubMedSearch in Google Scholar
  • 16 Frossard N, Melac M, Benabdesselam O, Pauli G. Consistency of the efficacy of cetirizine and ebastine on skin reactivity. Ann Allergy Asthma Immunol 1998; 80: 61-65.
    CrossrefPubMedSearch in Google Scholar
  • 17 Ginel PJ, Garrido C, Lucena R. Effects of otic betamethasone on intradermal testing in normal dogs. Vet Dermatol 2007; 18: 205-210.
    CrossrefPubMedSearch in Google Scholar
  • 18 Herman S, Vender RB. Antihistamines in the treatment of atopic dermatitis. J Cutan Med Surg 2003; 07 (06) 467-473.
    CrossrefPubMedSearch in Google Scholar
  • 19 Hillier A, De Boer DJ. The ACVD task force on canine atopic dermatitis XVII: intradermal testing. Vet Immunol Immunopathol 2001; 20: 289-304.
    PubMedSearch in Google Scholar
  • 20 Juhlin L, De Vos C, Rihoux J. Inhibiting effect of cetirizine on histamine-induced and 48/80-inducedwheals and flares, experimental dermographism, and cold-inducedurticaria. J Allergy Clin Immunol 1987; 80: 599-602.
    CrossrefPubMedSearch in Google Scholar
  • 21 Juhlin LA. Comparison of the pharmacodynamics of H1-receptor antagonists as assessed by the induced wheal-and-flare model. Allergy 1995; 50: 24-30.
    PubMedSearch in Google Scholar
  • 22 Michel L, De Vos C, Rihoux JP, Burtin C, Benveniste J, Dubertret L. Inhibitory effect of oral cetirizine on in vivo antigen-induced histamine and PAFacether release and eosinophil recruitment in human skin. J Allergy Clin Immunol 1988; 82: 101-109.
    CrossrefPubMedSearch in Google Scholar
  • 23 Pipkorn U, Hammarlund A, Enerback L. Prolonged treatment with topical glucocorticoids results in an inhibition of the allergen-induced wheal-andflare response and a reduction in skin mast cell numbers and histamine content. Clin Exp Allergy 1989; 19: 19-25.
    CrossrefPubMedSearch in Google Scholar
  • 24 Pucheu-Haston CM, Shuster D, Olivry T, Brianceau P, Lockwood P. McClanahan et al. A canine model of cutaneous late-phase reactions: prednisolone inhibition of cellular and cytokine responses. Immunology 2006; 117: 177-187.
    CrossrefPubMedSearch in Google Scholar
  • 25 Rees C. New drugs in veterinary dermatology. Vet Clin North Am Small Anim Pract 1999; 29: 1449-1460.
    CrossrefPubMedSearch in Google Scholar
  • 26 Rivierre C, Dunston SM, Olivry T. Effects of a 1 per cent hydrocortisone conditioner on the prevention of immediate and late-phase reactions in canine skin. Veb Rec 2000; 147: 739-742.
    PubMedSearch in Google Scholar
  • 27 Scott DW, Miller WH, Griffin CE. Atopic dermatitis In: Small Animal Dermatology. 5th ed.. Philadelphia, PA: Saunders; 2001: 574-601.
    Search in Google Scholar
  • 28 Simons FE. Evolution of H1-receptor antagonist treatment. Ann Allergy 1993; 71: 282-287.
    PubMedSearch in Google Scholar
  • 29 Snyder SH, Snowman AM. Receptor effects of cetirizine AM. Ann Allergy 1987; 59: 4-8.
    PubMedSearch in Google Scholar
  • 30 Spencer C, Faulds D, Peters D. Cetirizine. A reappraisal of its pharmacological properties and therapeutic use in selected allergic disorders. Drugs 1993; 46: 1055-1080.
    PubMedSearch in Google Scholar
  • 31 Sture GH, Halliwell RE, Thoday KL, Van den Broek AH, Henfrey JI, Lloyd DH. et al. Canine atopic disease: the prevalence of positive intradermal skin tests at two sites in the north and south of Great Britain.Vet Immunol Immunopathol. 1995; 44: 293-308.
    PubMedSearch in Google Scholar
  • 32 Takahashi H, Ishida-Yamamoto A, Iizuka H. Effects of bepotastine, cetirizine, fexofenadine, and olopatadine on histamine-induced wheal-and flareresponse, sedation, and psychomotor performance. Clin Exp Dermatol 2004; 29: 526-532.
    CrossrefPubMedSearch in Google Scholar
  • 33 Thomas RC, Logas D, Radosta L. Effects of a 1% hydrocortisone conditioner on hematological and biochemical parameters, adrenal function testing and cutaneous reactivity to histamine in normal and pruritic dogs. Vet Dermatol 1999; 10: 109-116.
    CrossrefPubMedSearch in Google Scholar