J Pediatr Infect Dis
DOI: 10.1055/s-0037-1620272
Case Report
Georg Thieme Verlag KG Stuttgart · New York

Intracranial Calcification after Probable Disseminated Bacillus Calmette–Guérin Infection in a Child with Severe Combined Immunodeficiency

Isil Eser
1  Division of Pediatric Allergy and Immunology, Kocaeli University, Kocaeli, Turkey
,
Zeynep Seda Uyan
2  Division of Pediatric Pulmonology, Kocaeli University, Kocaeli, Turkey
,
Suar Caki Kilic
3  Pediatric Stem Cell Transplantation Unit, Bahcesehir University, School of Medicine, Medical Park Goztepe Hospital, Istanbul, Turkey
,
Emek Uyur
4  Division of Pediatric Neurology, Kocaeli University, Kocaeli, Turkey
,
Emin Sami Arisoy
5  Division of Pediatric Infectious Diseases, Kocaeli University, Kocaeli, Turkey
,
Gulsun Tezcan
3  Pediatric Stem Cell Transplantation Unit, Bahcesehir University, School of Medicine, Medical Park Goztepe Hospital, Istanbul, Turkey
,
Metin Aydogan
1  Division of Pediatric Allergy and Immunology, Kocaeli University, Kocaeli, Turkey
› Author Affiliations
Further Information

Publication History

03 October 2017

11 December 2017

Publication Date:
16 January 2018 (eFirst)

Abstract

Bacillus Calmette–Guérin (BCG) vaccine is administered to infants in countries with a high prevalence of tuberculosis. Severe combined immunodeficiency (SCID) is one of the most severe forms of primary immunodeficiency disease, rendering patients prone to disseminated BCG infection. Early intensive antimycobacterial treatment and bone marrow transplantation may be lifesaving in patients with BCG infection and SCID. The central nervous system is rarely involved in BCG infection. We report a case of disseminated BCG infection with diffuse intracranial calcification, including periventricular white matter, subcortical area, pons and cerebellar white matter after bone marrow transplantation.