Pathophysiologie der Spondyloarthritiden

Zusammenfassung

Es besteht eine starke Korrelation zwischen dem Auftreten von HLA-B27 und der Prävalenz von ankylosierender Spondylitis (AS) und den anderen Spondyloarthritiden. Zusätzlich scheinen Umweltfaktoren eine Rolle bei der Krankheitsentstehung zu spielen. Vor allem Bakterien und deren Interaktion mit HLA-B27 werden hierbei diskutiert. Obwohl bereits zahlreiche Krankheitsmodelle zur Rolle von HLA-B27 und Mikroben bei der AS vorgestellt wurden, bleibt die Pathogenese dieser Erkrankung ungeklärt. Historische histologische Untersuchungen und aktuelle immunhistologische Arbeiten in der Wirbelsäule und an peripheren Gelenken von AS-Patienten erlauben interessante Rückschlüsse auf die Krankheitsentstehung der Spondyloarthritiden.

Summary

There is a strong correlation between the prevalence of HLA-B27 and the occurance of ankylosing spondylitis (AS) and other spondyloarthritides. Enviromental factors seem to play an important role in the pathogenesis. Bacteria and their interaction with HLA-B27 appear to be an important factor. Numerous disease models of spondyloarthritides have been proposed, trying to explain the association of spondyloarthritides with HLA-B27 and microbes. Historical histopathological analysis and recent immunohistochemical analysis of specimens from the spine and peripheral joints of AS patients allow interesting conclusions about the pathogenesis of spondyloarthritides

Schlüsselwörter

Spondyloarthritis - HLA-B27 - Histopathologie

Keywords

Spondyloarthritis - HLA-B27 - histopathology

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