Download PDF
Hamostaseologie 2004; 24(02): 116-122
DOI: 10.1055/s-0037-1619615
In eigener Sache
Schattauer GmbH

Hämostaseologie in der Pädiatrie

Blood coagulation disorders in children
K. Kurnik
1   Kinderklinik und Poliklinik im Dr. von Haunerschen Kinderspital (Direktor: Prof. Dr. D. Reinhardt), Klinikum Innenstadt, Ludwig-Maximilians-Universität München
› Author Affiliations
Further Information

Publication History

Publication Date:
27 December 2017 (online)

Also available at
    Permissions and Reprints

Zusammenfassung

Im Kindesalter werden so wie bei Erwachsenen hämorrhagische Diathesen und thrombotische Erkrankungen beobachtet. Die Ursachen können angeboren oder erworben sein. Angeborene Störungen manifestieren sich meist im Kleinkindalter. Zur Beurteilung von klinischem Befund in Verbindung mit Gerinnungsparametern ist die Kenntnis einiger pädiatrischer Besonderheiten wichtig. Nur so können adäquate Therapieentscheidungen getroffen werden.

Summary

As in adults, haemorrhagic or thrombotic events may also occur in children. The underlying reasons are inborn or acquired. Inherited disorders usually present during in early infancy. In order to interpret clinical and laboratory findings in children it is necessary to keep in mind some specific paediatric features. This knowledge also forms the basic requirement to choose the appropriate therapy.

Schlüsselwörter

Gerinnungsstörungen im Kindesalter - Blutungsneigung bei Kindern - Thrombosen im Kindesalter

Keywords

Coagulation disorders in children - haemorrhagic disorders in children - thrombophilia in children
 

  • Literatur

  • 1 Andrew M, Paes B, Milner R. et al. Development of the human coagulation system in the full-term infant. Blood 1987; 70: 165-72.
    PubMedGoogle Scholar
  • 2 Andrew M, Paes B, Milner R. et al. Development of the human coagulation system in the healthy premature infant. Blood 1988; 72: 1651-7.
    PubMedGoogle Scholar
  • 3 Andrew M, Vegh P, Johnston M. et al. Maturation of the hemostatic system during childhood. Blood 1992; 80: 1998-2005.
    PubMedGoogle Scholar
  • 4 Andrew M, David M, Adams M. et al. Venous thromboembolic complications (VTE) in children. Blood 1994; 83: 1251-7.
    CrossrefPubMedGoogle Scholar
  • 5 Andrew M, Michelson AD, Bovill E. et al. Guidelines for antithrombotic therapy in pediatric patients. J Pediatr 1998; 132: 375-88.
    PubMedGoogle Scholar
  • 6 Andrew M. Developmental hemostasis: Relevance to hemostatic problems during childhood. Sem Thromb Hemost 1995; 21: 341-56.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 7 Beynum van IM, Smeitink JA, den Heijer M. et al. Hyperhomocysteinemia, a risk factor for ischemic stroke in children. Circulation 1999; 99: 2070-2.
    CrossrefPubMedGoogle Scholar
  • 8 Bolton-Maggs PHB, Moon J. Assessment of UK practice for management of acute childhood idiopathic thrombocytopenic purpura against published guidelines. Lancet 1997; 350: 620-3.
    CrossrefPubMedGoogle Scholar
  • 9 Hiller E, Riess H, Auberger K. Hämorrhagische Diathese und Thrombose. Stuttgart: Wissenschaftliche Verlagsgesellschaft; 1998
    Google Scholar
  • 10 Jorch G. Vitamin-K-Prophylaxe bei Neugeborenen. Pädiat Prax 1998; /99; 55: 585-8.
    PubMedGoogle Scholar
  • 11 Junker R, Koch HG, Auberger K. et al. Prothrombin G20210A gene mutation and further risk factors in childhood thrombophilia. Arterioscler Thromb Vasc Biol 1999; 19: 2568-72.
    CrossrefPubMedGoogle Scholar
  • 12 Kries von R, Göbel U. Blutgerinnungsstörungen im Kindesalter. Monatsschr Kinderheilk 1993; 141: 137-49.
    PubMedGoogle Scholar
  • 13 Moser R, Panzer S, Mutz I. Neonatale Alloimmunthrombozytopenie als Ursache von Thrombozytopenien neugeborener Kinder. Pädiat Prax 1998; /99; 55: 601-10.
    PubMedGoogle Scholar
  • 14 Kosch A, Kries von R, Nowak-Göttl U. Thrombosen im Kindesalter. Monatsschr Kinderheilk 2000; 148: 387-97.
    CrossrefPubMedGoogle Scholar
  • 15 Nowak-Göttl U, Schwabe D. Thrombolysetherapie im Kindesalter. Monatsschr Kinderheilk 1995; 143: 290-4.
    PubMedGoogle Scholar
  • 16 Nowak-Göttl U, Kries von R, Gobel U. Neonatal symptomatic thromboembolism in Germany. Arch Dis Childh 1997; 76: F163-7.
    CrossrefPubMedGoogle Scholar
  • 17 Nowak-Göttl U, Ehrenfort S, Junker R. et al. Combined prothrombotic risk factors associated with early thromboembolism in infancy and childhood. Ann Hematol 1998; 76: A77.
    PubMedGoogle Scholar
  • 18 Nowak-Göttl U, Auberger K, Halimeh S. et al. Thrombolysis in newborn and infants. Thromb Haemost 1999; 82 (Suppl. 01) 112-6.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 19 Nowak-Göttl U, Junker R, Hartmeier M. et al. Increased lipoprotein(a) is an important risk factor for venous thromboembolism in childhood. Circulation 1999; 100: 743-8.
    CrossrefPubMedGoogle Scholar
  • 20 Ries M, Deeg KH. Thromboembolische Erkrankungen im Kindesalter. Pädiat Prax 1999; 56: 401-15.
    PubMedGoogle Scholar
  • 21 Schlüter B, Bürk G, Jaeken I. et al. Primäres Hypoglykosierungssyndrom Typ 1. Monatsschr Kinderheilk 1995; 143: 31-5.
    PubMedGoogle Scholar
  • 22 Sutor AH. (Hrg). Thrombocytopenia in Childhood. Stuttgart: Schattauer; 1994
    Google Scholar
  • 23 Sutor AH, Kries von R, Cornelissen EA. et al. Vitamin K deficiency bleeding (VKDB) in infancy. Thromb Haemost 1999; 81: 456-61.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 24 Mingers AM, Sutor AH. Lupusinhibitoren im Kindesalter. Hämostaseologie 1992; 12: 101-6.
    Article in Thieme ConnectPubMedGoogle Scholar