Pneumologie 2018; 72(S 01): S109
DOI: 10.1055/s-0037-1619413
Sektion 12 – Prävention, Rehabilitation und Tabakkontrolle
Posterbegehung – Titel: Neues aus Rehabilitation und Tabakentwöhnung
Georg Thieme Verlag KG Stuttgart · New York

Is EQ-5D suited to assess quality of life aspects in pulmonary rehabilitation in bronchial asthma

B Szentes
1   Deutsches Foschungszentrum für Gesundheit und Umwelt, Helmholtz Zentrum München
,
L Schwarzkopf
1   Deutsches Foschungszentrum für Gesundheit und Umwelt, Helmholtz Zentrum München
,
N Lehbert
2   Zentrum für Rehabilitation, Klinik Bad Reichenhall der DRV Bayern Süd
,
M Wittmann
2   Zentrum für Rehabilitation, Klinik Bad Reichenhall der DRV Bayern Süd
,
R Wagner
2   Zentrum für Rehabilitation, Klinik Bad Reichenhall der DRV Bayern Süd
,
D Nowak
3   Institut und Poliklinik für Arbeits-, Sozial- und Umweltmedizin, Klinikum der Universität München
,
H Faller
4   Abteilung für Medizinische Psychologie und Psychotherapie, Universität Würzburg
,
M Schuler
4   Abteilung für Medizinische Psychologie und Psychotherapie, Universität Würzburg
,
K Schultz
2   Zentrum für Rehabilitation, Klinik Bad Reichenhall der DRV Bayern Süd
› Author Affiliations
Further Information

Publication History

Publication Date:
21 February 2018 (online)

Also available at
 

Background:

EQ-5D-5L is a well-established generic quality of life (QoL) assessment tool, also used for calculating quality adjusted life years. Its suitability in context of pulmonary rehabilitation (PR) in bronchial asthma has not been fully assessed yet.

Methods:

We calculated mean EQ-5D (Visual analog scale (VAS), experience -based values) and disease-specific AQLQ (Asthma QoL questionnaire) at start (T1), at end (T2) and 3 months after (T3) PR for 184 patients with uncontrolled asthma (Asthma Control Test< 20) from the ongoing EPRA study. We assessed correlations (Pearson's r) between EQ-5D and AQLQ and their sensitivity to changes (Cohen's d).

Results:

Both, EQ-5D and AQLQ values showed improved QoL immediately and 3 months after PR. QoL gains decreased over time, but remained substantially above the level before PR. AQLQ was more sensitive to changes than EQ-5D particularly just after PR but comparable to VAS after 3 months. The instruments correlated moderately with slightly higher Pearsons r after 3 months.

Tab. 1:

Development of the QoL measurements and their correlation

N = 184

T1

Mean (SD)

T2

Mean (SD)

T3

Mean (SD)

T1→T2

Cohen's d *[95CI]

T1→T3

Cohen's d *[95CI]

EQ-5D experience based values

0.69 (0.14)

0.79 (0.12)

0.78 (0.12)

0.78 [0.57 – 0.99]

0.61 [0.39 – 0.82]

VAS

59.51 (16.79)

78.17 (15.44)

76.14 (18.41)

1.16 [0.94 – 1.38]

0.94 [0.73 – 1.16]

AQLQ

4.45 (0.97)

5.68 (0.99)

5.46 (1.18)

1.25 [0.71 – 1.48]

0.93 [0.71 – 1.15]

Corr EQ-5D-5L experience based values AQLQ

0.63

0.58

0.62

Corr AQLQ VAS

0.54

0.66

0.72

*0.2 – 0.5 small, 0.5 – 0.8 moderate, > 0.8 strong effect

Discussion:

PR is associated with a substantial and sustainable QoL improvement and corresponding changes can be well detected by EQ-5D-especially the VAS. Given moderate correlation of AQLQ and EQ-5D which even improves over time, EQ-5D should gain importance as supporting tool for health care decision making in the field of PR.

Supported by Deutsche Rentenversicherung Bayern.