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Thromb Haemost 2001; 86(01): 298-307
DOI: 10.1055/s-0037-1616227
Research Article
Schattauer GmbH

Protease-activated Receptors in Vascular Biology

Shaun Coughlin
1   Cardiovascular Research Institute, Departments of Medicine, and Department of Cellular and Molecular Pharmacology University of California, San Francisco, CA, USA
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Publication History

Publication Date:
12 December 2017 (online)

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Summary

G protein-coupled protease-activated receptors (PARs) provide one answer to the question of how coagulation factors and other proteases regulate cellular behaviors. In concert with the coagulation cascade, these receptors provide an elegant mechanism that links mechanical information in the form of tissue injury or vascular leak to cellular responses. Roles for PARs in hemostasis and thrombosis, inflammation, and perhaps even blood vessel development are beginning to emerge. Our current understanding of the role of PARs in platelet and endothelial cell activation and their potential importance in normal and disease states is discussed.

Key words

Thrombin - receptors - platelets - endothelial cells - signaling
 

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