J Pediatr Infect Dis 2019; 14(01): 013-015
DOI: 10.1055/s-0037-1615784
Review Article
Georg Thieme Verlag KG Stuttgart · New York

Serotype Distribution of Streptococcus pneumoniae causing Invasive Pneumococcal Disease at Bambino Gesù Children's Hospital in Rome: Is It Time for a New Vaccine?

Luciana Nicolosi
1  UOC Pediatric and Infectious Disease, Bambino Gesù Children's Hospital, Rome, Italy
,
Elena Bozzola
1  UOC Pediatric and Infectious Disease, Bambino Gesù Children's Hospital, Rome, Italy
,
Andrzej Krzysztofiak
1  UOC Pediatric and Infectious Disease, Bambino Gesù Children's Hospital, Rome, Italy
,
Annausa Pantosti
2  Department of Infectious, Parasitic and Immune-mediated Diseases, National Institute of Health, Rome, Italy
,
Laura Lancella
1  UOC Pediatric and Infectious Disease, Bambino Gesù Children's Hospital, Rome, Italy
,
Paola Bernaschi
3  UOS Microbiology, Bambino Gesù Children's Hospital, Rome, Italy
,
Maria Rosaria Marchili
1  UOC Pediatric and Infectious Disease, Bambino Gesù Children's Hospital, Rome, Italy
,
Alberto Villani
1  UOC Pediatric and Infectious Disease, Bambino Gesù Children's Hospital, Rome, Italy
› Author Affiliations
Further Information

Publication History

21 December 2016

05 November 2017

Publication Date:
02 January 2018 (online)

Abstract

Diseases caused by Streptococcus pneumoniae are mostly preventable infections by current immunization programs. The objective of this study was to evaluate the impact of the introduction of the heptavalent and the 13-valent pneumococcal conjugate vaccines (PCV7 and PCV13) on the burden of pneumococcal disease and on the serotype distribution of S. pneumoniae causing invasive pneumococcal diseases (IPDs) in the pediatric age over a 5-year study (from January 2008 till December 2012). We observed a decrease in IPD rate in children after PCV13 introduction despite increases in nonvaccine serotype (NVS) rates in 2011. Nevertheless, from 2012, an increase in IPD rates due to non-PCV13 serotypes was observed.