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Thromb Haemost 1999; 82(05): 1490-1496
DOI: 10.1055/s-0037-1614860
Rapid Communications
Schattauer GmbH

Relationship between Visceral Fat and PAI-1 in Overweight Men and Women before and after Weight Loss

M. Kockx
1   From the Gaubius Laboratory TNO-PG, Leiden, The Netherlands
,
R. Leenen   *
2   Department of Chronic Diseases and Environmental Epidemiology, National Institute of Public Health and The Environment, Bilthoven, The Netherlands
,
J. Seidell
2   Department of Chronic Diseases and Environmental Epidemiology, National Institute of Public Health and The Environment, Bilthoven, The Netherlands
,
H. M. G. Princen
1   From the Gaubius Laboratory TNO-PG, Leiden, The Netherlands
,
T. Kooistra
1   From the Gaubius Laboratory TNO-PG, Leiden, The Netherlands
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Publikationsverlauf

Received 03. November 1998

Accepted after resubmission 27. Mai 1999

Publikationsdatum:
09. Dezember 2017 (online)

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Summary

This study was aimed at evaluating the relationship between visceral fat accumulation and plasma plasminogen activator inhibitor-1 (PAI-1) levels in healthy, obese men and women undergoing weight loss therapy. The subjects, 25 men and 25 premenopausal women, aged between 26 and 49 years, with an initial body mass index between 28 and 38 kg/m2, received a controlled diet for 13 weeks providing a 4.2 MJ/day energy deficit. Magnetic resonance imaging was used to measure visceral and subcutaneous abdominal fat. Our results show that before weight loss visceral fat was significantly correlated with PAI-1 in men (r = 0.45; p <0.05), but not in women (r = -0.15; ns). The association between visceral fat and PAI-1 in men remained significant after adjustment for age and total fat mass, and multiple linear regression analysis showed a significant independent contribution of visceral fat to plasma PAI-1 levels. Both visceral fat areas and PAI-1 levels decreased significantly with weight loss in both men and women. Changes in visceral fat area were related to changes in PAI-1 in women (r = -0.43; p = 0.05) but not in men (r = -0.01; ns); however, this association in women disappeared after adjustment for total fat mass. We conclude that there is a relationship between visceral fat and PAI-1 in obese men but not in obese women, and that PAI-1 levels decrease substantially (52%) by weight loss, but this change is not related to changes in visceral fat mass per se.

Key words

PAI-1 - obesity - visceral fat - weight loss

* Present address: Dr. R. Leenen, Unilever Research Laboratory, Vlaardingen, The Netherlands


 

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