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Thromb Haemost 1999; 81(04): 663-664
DOI: 10.1055/s-0037-1614546
DOI: 10.1055/s-0037-1614546
Letters to the Editor
Recurrent Thrombosis in a Patient with Pseudohomozygous Activated Protein C Resistance and Homozygosity for MTHFR Gene Polymorphism C677T
Further Information
Publication History
Received
03 September 1998
Accepted after resubmission
05 January 1999
Publication Date:
09 December 2017 (online)
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References
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- 2 Simioni P, Scudeller A, Radossi P, Gavasso S, Girolami B, Tormene D, Girolami A. “Pseudohomozygous” activated protein C resistance due to double heterozygous factor V defects (factor V Leiden mutation and type I quantitative factor V defect) associated with thrombosis: report of two cases belonging to two unrelated kindreds. Thromb Haemost 1996; 75: 422-26.
- 3 Zehnder JL, Jain M. Recurrent thrombosis due to compound heterozygosity for factor V Leiden and factor V deficiency. Blood Coagul Fibrinolysis 1996; 7: 361-2.
- 4 Casterman G, Lunghi B, Missiaglia E, Bernardi F, Rodeghiero F. Phenotypic homozygous activated protein C resistance associated with compound heterozygosity for Arg506Gln (factor V Leiden) and His1299Arg substitutions in factor V. Br J Haematol 1997; 99: 257-61.
- 5 Girolami A, Simioni P, Scarano L, Girolami B, Marchiori A. Haemorrhagic and thrombotic disorders due to factor V deficiencies and abnormalities: an updated classification. Blood Rev 1998; 12: 45-51.
- 6 Zighetti ML, Cattaneo M, Tsai MY, Bucciarelli P, Taioli E, Bignell M, Mannucci PM. A common mutation in the methylene-tetrahydrofolate reductase gene (C677T) increases the risk for deep-vein thrombosis in patients with mutant factor V (factor V:Q506 ). Thromb Haemost 1997 Supplement 570.
- 7 Morse C, Standen G. Specificity of ‘clotting’ methods for factor V Leiden. Br. J Haematol 1996; 95: 432-433.