Thromb Haemost 2004; 91(04): 843-845
DOI: 10.1055/s-0037-1614282
Letters to the Editor
Schattauer GmbH

C677T and A1298C single nucleotide polymorphisms in the methylenetetrahydrofolate reductase gene among Bahraini Arabs

Hanaa H. Al-Habboubi
,
Hala Tamim
,
Ghada Ameen
,
Wassim Y. Almawi
Further Information

Publication History

Received 24 September 2003

Accepted after revision 05 December 2003

Publication Date:
08 December 2017 (online)

 

 
  • References

  • 1 Jacques PF, Bostom AG, Williams RR. et al. Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations. Circulation 1996; 93: 7-9.
  • 2 Graham IM, Daly LE, Refsum HM. et al. Plasma homocysteine as a risk factor for vascular disease. The European Concerted Action Project. JAMA 1997; 277: 1775-81.
  • 3 Dierkes J, Bisse E, Nauck M. et al. The diagnostic value of serum homocysteine concentration as a risk factor for coronary artery disease. Clin Chem Lab Med 1998; 36: 453-7.
  • 4 Frosst P, Blom HJ, Milos R. et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 1995; 01: 111-3.
  • 5 Arruda VR, von Zuben PM, Chiaparini LC. et al. The mutation Ala677→Val in the methylene tetrahydrofolate reductase gene: a risk factor for arterial disease and venous thrombosis. Thromb Haemost 1997; 77: 818-21.
  • 6 Brattstrom L, Wilcken DE, Ohrvik J. et al. Common methylenetetrahydrofolate reductase gene mutation leads to hyperhomocysteinemia but not to vascular disease: the result of a meta-analysis. Circulation 1998; 98: 2520-6.
  • 7 Angchaisuksiri P, Pingsuthiwong S, Sura T. et al. Prevalence of the C677T methylenetetrahydrofolate reductase mutation in Thai patients with deep vein thrombosis. Acta Haematol 2000; 103: 191-6.
  • 8 Mukherjee M, Joshi S, Bagadi S. et al. A low prevalence of the C677T mutation in the methylenetetrahydrofolate reductase gene in Asian Indians. Clin Genet 2002; 61: 155-9.
  • 9 Mutchinick OM, Lopez MA, Luna L. et al. High prevalence of the thermolabile methylenetetrahydrofolate reductase variant in Mexico: a country with a very high prevalence of neural tube defects. Mol Genet Metab 1999; 68: 461-7.
  • 10 Weisberg I, Tran P, Christensen B. et al. A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity. Mol Genet Metabol 1998; 64: 169-72.
  • 11 Friso S, Girelli D, Trabetti E. et al. A1298C methylenetetrahydrofolate reductase mutation and coronary artery disease: relationships with C677T polymorphism and homocysteine/folate metabolism. Clin Exp Med 2002; 02: 7-12.
  • 12 Change A, Boisson F, Barbe F. et al. The effect of 677C→T and 1298A→C mutations on plasma homocysteineand5,10-methylenetetrahydrofolate reductase activity in healthy subjects. Br J Nutr 2000; 83: 593-6.
  • 13 Alfirevic Z, Mousa HA, Martlew V. et al. Postnatal screening for thrombophilia in women with severe pregnancy complications. Ob-stet Gynecol 2001; 97: 753-9.
  • 14 Nishio H, Lee MJ, Fujii M. et al. A common mutation in methylenetetrahydrofolate reductase gene among the Japanese population. Jpn J Hum Genet 1996; 41: 247.
  • 15 Hsu LA, Ko YL, Wang SM. et al. The C677T mutation of the methylenetetrahydrofolate reductase gene is not associated with the risk of coronary artery disease or venous thrombosis among Chinese in Taiwan. Hum Hered 2001; 51: 41-5.
  • 16 Esfahani ST, Cogger EA, Caudill MA. Heterogeneity in the prevalence of methylenetetrahydrofolate reductase gene polymorphisms in women of different ethnic groups. J Am Diet Assoc 2003; 103: 200-7.
  • 17 Peng F, Labelle LA, Rainey BJ. et al. Single nucleotide polymorphisms in the methylenetetrahydrofolate reductase gene are common in US Caucasian and Hispanic American populations. Int J Mol Med 2001; 08: 509-11.
  • 18 Keijzer MB, den Heijer M, Blom HJ. et al. Interaction between hyperhomocysteinemia, mutated methylenetetrahydrofolate-reductase (MTHFR) and inherited throombophilic factors in recurrent venous thrombosis. Thromb Hae-most 2002; 88: 723-8.