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Thromb Haemost 2004; 91(04): 824-825
DOI: 10.1055/s-0037-1614271
Letters to the Editor
Schattauer GmbH

Allelic frequency of the factor V Leiden mutation and of the prothrombin gene 20210A mutation in healthy Tunisian population

Lobna Bouaziz
,
Nathalie Hézard
,
Mahjoub Touhami
,
Gérard Potron
,
Brahim N’siri
,
Philippe Nguyen
Further Information

Publication History

Received 31 July 2003

Accepted 22 September 2003

Publication Date:
08 December 2017 (online)

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  • References

  • 1 Dahlback B, Carlsson M, Svensson PJ. Familial thrombophilia due to a previously unrecognised mechanism characterised by poor anticoagulant response to activated protein C: Prediction of a cofactor to activated protein C. Proc Natl Acad Sci USA 1993; 90: 1004-8.
    CrossrefPubMedGoogle Scholar
  • 2 Poort SR, Rosendaal FR, Reitsma PH. et al. A common genetic variation in the 3- untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis. Blood 1996; 88: 3698-703.
    PubMedGoogle Scholar
  • 3 Rees DC, Cox M, Clegg JB. World distribution of factor V Leiden. Lancet 1995; 346: 1133-4.
    CrossrefPubMedGoogle Scholar
  • 4 Pepe G, Rickards O, Vanegas OC. et al. Prevalence of factor V Leiden mutation in non-European populations. Thromb Haemost 1997; 77: 329-31.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 5 Hessner MJ, Luhm RA, Pearson SL. et al. Prevalence of prothrombin G20210A, factor V G1691 A (Leiden), and methylenetetrahydro-folate reductase (MTHFR) C677T in seven different populations determined by Multiplex allele-specific PCR. Thromb Haemost 1999; 81: 733-8.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 6 Chafa O, Reghis A, Aubert A. et al. Prevalence of the FVQ506 (factor V Leiden) mutation in the normal and thrombophilic Algerian population. Br J Haematol 1997; 97: 688-9.
    PubMedGoogle Scholar
  • 7 Helley D, Chafa O, Yaker NJ. et al. Prevalence of the prothrombin gene 20210 A mutation in thrombophilic and healthy Algerian subjects. Thromb Haemost 1999; 82: 1554-5.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 8 Mathonnet F, Nadifi S, Serazin-Leroy V. et al. Absence of factor V Leiden mutation and low prothrombin G 20210 A mutation prevalence in a healthy Moroccan population. Thromb Haemost 2002; 88: 1073-4.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 9 Hezard N, Cornillet-Lefebvre P, Gillot L. et al. Multiplex ASA PCR for a simultaneous determination of factor V Leiden gene, G→A 20210 prothrombin gene and C→T 677 MTHFR gene mutations. Thromb Haemost 1998; 79: 1054-5.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 10 Rosendaal FR, Doggen CJM, Zivelin A. et al. Geographic distribution of the 20210 G to A prothrombin variant. Thromb Haemost 1998; 79: 706-8.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 11 Ozbek U, Tangün Y. Frequency of factor V Leiden (Arg 506 Gln) in Turkey. Br J Haematol 1997; 97: 504-5.
    CrossrefPubMedGoogle Scholar
  • 12 Togrul J, Rustamov R, Grey A. et al. Prevalence of the prothrombin gene G20210 A mutation in Azerbaijan. Br J Haematol 2000; 108: 887-8.
    CrossrefPubMedGoogle Scholar