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Thromb Haemost 2000; 83(03): 427-432
DOI: 10.1055/s-0037-1613832
DOI: 10.1055/s-0037-1613832
Review Article
Haemostatic Factors in Human Peripheral Afferent Lymph
Authors
Weitere Informationen
Publikationsverlauf
Received
21. Juli 1999
Accepted after rebsubmission
22. November 1999
Publikationsdatum:
14. Dezember 2017 (online)
Summary
Peripheral afferent lymph was obtained by cannulation of a collecting vessel in 17 healthy men (mean age 26 years). Lymph/plasma ratios of all vitamin K-dependent factors were lower than expected from molecular weight. Factor VII, factor IX and tissue factor pathway inhibitor (TFPI) lymph/plasma activity ratios were higher than antigen ratios. Activated factor VII (FVIIa) and TFPI-Xa complex concentrations were higher in lymph than plasma, and the raised FVIIa did not appear to be due to cannulation. The fibrinogen lymph/plasma activity (Clauss) ratio averaged about 20% of the antigen ratio. The result of an ELISA for D-dimer was higher in lymph than plasma, often more than five-fold. This high level in lymph was not explored but may indicate proteolysis of fibrinogen and fibrin with release of D-like and D-dimerlike fragments in interstitial fluid.
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